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- W3010678440 endingPage "2081" @default.
- W3010678440 startingPage "2081" @default.
- W3010678440 abstract "Non-Hodgkin lymphomas (NHL) are lymphoid tumors that arise by a complex process of malignant transformation of mature lymphocytes during various stages of differentiation. The WHO classification of NHL recognizes more than 90 nosological units with peculiar pathophysiology and prognosis. Since the end of the 20th century, our increasing knowledge of the molecular biology of lymphoma subtypes led to the identification of novel druggable targets and subsequent testing and clinical approval of novel anti-lymphoma agents, which translated into significant improvement of patients’ outcome. Despite immense progress, our effort to control or even eradicate malignant lymphoma clones has been frequently hampered by the development of drug resistance with ensuing unmet medical need to cope with relapsed or treatment-refractory disease. A better understanding of the molecular mechanisms that underlie inherent or acquired drug resistance might lead to the design of more effective front-line treatment algorithms based on reliable predictive markers or personalized salvage therapy, tailored to overcome resistant clones, by targeting weak spots of lymphoma cells resistant to previous line(s) of therapy. This review focuses on the history and recent advances in our understanding of molecular mechanisms of resistance to genotoxic and targeted agents used in clinical practice for the therapy of NHL." @default.
- W3010678440 created "2020-03-23" @default.
- W3010678440 creator A5048016549 @default.
- W3010678440 creator A5085470006 @default.
- W3010678440 date "2020-03-18" @default.
- W3010678440 modified "2023-10-16" @default.
- W3010678440 title "Drug Resistance in Non-Hodgkin Lymphomas" @default.
- W3010678440 cites W1132077651 @default.
- W3010678440 cites W1192491316 @default.
- W3010678440 cites W1687898 @default.
- W3010678440 cites W1754065147 @default.
- W3010678440 cites W1776168062 @default.
- W3010678440 cites W1826425651 @default.
- W3010678440 cites W1905059524 @default.
- W3010678440 cites W1936851784 @default.
- W3010678440 cites W1937619611 @default.
- W3010678440 cites W1947298690 @default.
- W3010678440 cites W1966062502 @default.
- W3010678440 cites W1998728654 @default.
- W3010678440 cites W1999233413 @default.
- W3010678440 cites W1999824748 @default.
- W3010678440 cites W2006177081 @default.
- W3010678440 cites W2010711123 @default.
- W3010678440 cites W2013909810 @default.
- W3010678440 cites W2022256282 @default.
- W3010678440 cites W2023947368 @default.
- W3010678440 cites W2028681024 @default.
- W3010678440 cites W2031299149 @default.
- W3010678440 cites W2032788851 @default.
- W3010678440 cites W2040785900 @default.
- W3010678440 cites W2043415097 @default.
- W3010678440 cites W2050231360 @default.
- W3010678440 cites W2051181260 @default.
- W3010678440 cites W2054719244 @default.
- W3010678440 cites W2055185352 @default.
- W3010678440 cites W2055491283 @default.
- W3010678440 cites W2058015212 @default.
- W3010678440 cites W2058574523 @default.
- W3010678440 cites W2066404900 @default.
- W3010678440 cites W2066564017 @default.
- W3010678440 cites W2074129070 @default.
- W3010678440 cites W2076171986 @default.
- W3010678440 cites W2087516193 @default.
- W3010678440 cites W2087945287 @default.
- W3010678440 cites W2101648653 @default.
- W3010678440 cites W2103109966 @default.
- W3010678440 cites W2104746788 @default.
- W3010678440 cites W2104940816 @default.
- W3010678440 cites W2106391833 @default.
- W3010678440 cites W2108156595 @default.
- W3010678440 cites W21149459 @default.
- W3010678440 cites W2118524916 @default.
- W3010678440 cites W2124153379 @default.
- W3010678440 cites W2133192145 @default.
- W3010678440 cites W2134861285 @default.
- W3010678440 cites W2139891818 @default.
- W3010678440 cites W2141037581 @default.
- W3010678440 cites W2146043241 @default.
- W3010678440 cites W2150382709 @default.
- W3010678440 cites W2154066874 @default.
- W3010678440 cites W2158255028 @default.
- W3010678440 cites W2159890109 @default.
- W3010678440 cites W2168926834 @default.
- W3010678440 cites W2169859012 @default.
- W3010678440 cites W2207663629 @default.
- W3010678440 cites W2216217499 @default.
- W3010678440 cites W2253853328 @default.
- W3010678440 cites W2310716991 @default.
- W3010678440 cites W2312804644 @default.
- W3010678440 cites W2329648702 @default.
- W3010678440 cites W2343431529 @default.
- W3010678440 cites W2345102372 @default.
- W3010678440 cites W2406971307 @default.
- W3010678440 cites W2407062960 @default.
- W3010678440 cites W2409945629 @default.
- W3010678440 cites W2417431203 @default.
- W3010678440 cites W2419639370 @default.
- W3010678440 cites W2428921896 @default.
- W3010678440 cites W2430862255 @default.
- W3010678440 cites W2441107086 @default.
- W3010678440 cites W2476698801 @default.
- W3010678440 cites W2534349779 @default.
- W3010678440 cites W2537551256 @default.
- W3010678440 cites W2565527182 @default.
- W3010678440 cites W2581658669 @default.
- W3010678440 cites W2582696216 @default.
- W3010678440 cites W2584150336 @default.
- W3010678440 cites W2606935597 @default.
- W3010678440 cites W2618385398 @default.
- W3010678440 cites W2620804057 @default.
- W3010678440 cites W2623658063 @default.
- W3010678440 cites W2729141564 @default.
- W3010678440 cites W2731842610 @default.
- W3010678440 cites W2736713143 @default.
- W3010678440 cites W2755677304 @default.
- W3010678440 cites W2760635695 @default.
- W3010678440 cites W2762226752 @default.
- W3010678440 cites W2763367287 @default.