Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010681570> ?p ?o ?g. }
- W3010681570 endingPage "e0229801" @default.
- W3010681570 startingPage "e0229801" @default.
- W3010681570 abstract "We report the synthesis and preliminary characterization of IODVA1, a potent small molecule that is active in xenograft mouse models of Ras-driven lung and breast cancers. In an effort to inhibit oncogenic Ras signaling, we combined in silico screening with inhibition of proliferation and colony formation of Ras-driven cells. NSC124205 fulfilled all criteria. HPLC analysis revealed that NSC124205 was a mixture of at least three compounds, from which IODVA1 was determined to be the active component. IODVA1 decreased 2D and 3D cell proliferation, cell spreading and ruffle and lamellipodia formation through downregulation of Rac activity. IODVA1 significantly impaired xenograft tumor growth of Ras-driven cancer cells with no observable toxicity. Immuno-histochemistry analysis of tumor sections suggests that cell death occurs by increased apoptosis. Our data suggest that IODVA1 targets Rac signaling to induce death of Ras-transformed cells. Therefore, IODVA1 holds promise as an anti-tumor therapeutic agent." @default.
- W3010681570 created "2020-03-23" @default.
- W3010681570 creator A5006356134 @default.
- W3010681570 creator A5011555706 @default.
- W3010681570 creator A5020676075 @default.
- W3010681570 creator A5032390904 @default.
- W3010681570 creator A5032415102 @default.
- W3010681570 creator A5035311994 @default.
- W3010681570 creator A5050751520 @default.
- W3010681570 creator A5052372180 @default.
- W3010681570 creator A5066894344 @default.
- W3010681570 creator A5067052365 @default.
- W3010681570 creator A5069766135 @default.
- W3010681570 creator A5073333838 @default.
- W3010681570 creator A5076088772 @default.
- W3010681570 creator A5078818594 @default.
- W3010681570 date "2020-03-12" @default.
- W3010681570 modified "2023-10-10" @default.
- W3010681570 title "IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models" @default.
- W3010681570 cites W1486949824 @default.
- W3010681570 cites W1563198913 @default.
- W3010681570 cites W1598659248 @default.
- W3010681570 cites W1622452078 @default.
- W3010681570 cites W1629179716 @default.
- W3010681570 cites W1818943734 @default.
- W3010681570 cites W1824220821 @default.
- W3010681570 cites W1849819493 @default.
- W3010681570 cites W1852094985 @default.
- W3010681570 cites W1896854564 @default.
- W3010681570 cites W1964930474 @default.
- W3010681570 cites W1965560515 @default.
- W3010681570 cites W1973568716 @default.
- W3010681570 cites W1973974137 @default.
- W3010681570 cites W1989233227 @default.
- W3010681570 cites W1991634478 @default.
- W3010681570 cites W2001752971 @default.
- W3010681570 cites W2002547287 @default.
- W3010681570 cites W2005508652 @default.
- W3010681570 cites W2007660746 @default.
- W3010681570 cites W2008915115 @default.
- W3010681570 cites W2008922681 @default.
- W3010681570 cites W2011544204 @default.
- W3010681570 cites W2012479646 @default.
- W3010681570 cites W2018244287 @default.
- W3010681570 cites W2019528050 @default.
- W3010681570 cites W2019731805 @default.
- W3010681570 cites W2020231002 @default.
- W3010681570 cites W2020733170 @default.
- W3010681570 cites W2023612761 @default.
- W3010681570 cites W2024631759 @default.
- W3010681570 cites W2024944232 @default.
- W3010681570 cites W2025581210 @default.
- W3010681570 cites W2027482274 @default.
- W3010681570 cites W2027551150 @default.
- W3010681570 cites W2027975056 @default.
- W3010681570 cites W2028121524 @default.
- W3010681570 cites W2032335134 @default.
- W3010681570 cites W2033882981 @default.
- W3010681570 cites W2036145275 @default.
- W3010681570 cites W2045261036 @default.
- W3010681570 cites W2046662414 @default.
- W3010681570 cites W2046968871 @default.
- W3010681570 cites W2047743989 @default.
- W3010681570 cites W2052214665 @default.
- W3010681570 cites W2053423866 @default.
- W3010681570 cites W2053507081 @default.
- W3010681570 cites W2054332795 @default.
- W3010681570 cites W2066505046 @default.
- W3010681570 cites W2077421078 @default.
- W3010681570 cites W2083268673 @default.
- W3010681570 cites W2091169894 @default.
- W3010681570 cites W2093226717 @default.
- W3010681570 cites W2096180149 @default.
- W3010681570 cites W2098223144 @default.
- W3010681570 cites W2099536948 @default.
- W3010681570 cites W2101278965 @default.
- W3010681570 cites W2105668062 @default.
- W3010681570 cites W2107942104 @default.
- W3010681570 cites W2117911065 @default.
- W3010681570 cites W2128569116 @default.
- W3010681570 cites W2131554707 @default.
- W3010681570 cites W2131564236 @default.
- W3010681570 cites W2132925790 @default.
- W3010681570 cites W2141080960 @default.
- W3010681570 cites W2152265294 @default.
- W3010681570 cites W2155127143 @default.
- W3010681570 cites W2156571424 @default.
- W3010681570 cites W2158534713 @default.
- W3010681570 cites W2159615687 @default.
- W3010681570 cites W2160762156 @default.
- W3010681570 cites W2164282019 @default.
- W3010681570 cites W2165526004 @default.
- W3010681570 cites W2165670223 @default.
- W3010681570 cites W2176511881 @default.
- W3010681570 cites W2176516200 @default.
- W3010681570 cites W2204540292 @default.
- W3010681570 cites W2295798984 @default.
- W3010681570 cites W2307031748 @default.