FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010686323> ?p ?o ?g. }

• W3010686323 endingPage "1018" @default.
• W3010686323 startingPage "1010" @default.
• W3010686323 abstract "Abstract Polypharmacy (use of ≥5 medications) and increasing Drug Burden Index (DBI) score (measure of person’s total exposure to anticholinergic/sedative medications) are associated with impaired physical function in observational studies of older adults. Deprescribing, the supervised withdrawal of medications for which harms outweigh benefits for an individual, may be a useful intervention. Current knowledge is limited to clinical observational studies that are unable to determine causality. Here, we establish a preclinical model that investigates the effects of chronic polypharmacy, increasing DBI, and deprescribing on global health outcomes in aging. In a longitudinal study, middle-aged (12 months) male C57BL/6J (B6) mice were administered control feed or feed and/or water containing polypharmacy or monotherapy with different DBI scores. At 21 months, each treatment group was subdivided (stratified by frailty at 21 months) to either continue on treatment for life or to have treatment withdrawn (deprescribed). Frailty and physical function were evaluated at 12, 15, 18, and 24 months, and were analyzed using a mixed modeling approach. Polypharmacy with increasing DBI and monotherapy with citalopram caused mice to become frailer, less mobile, and impaired their strength and functional activities. Critically, deprescribing in old age reversed a number of these outcomes. This is the first preclinical study to demonstrate that chronic polypharmacy with increasing DBI augments frailty and impairs function in old age, and that drug withdrawal in old age reversed these outcomes. It was not the number of drugs (polypharmacy) but the type and dose of drugs (DBI) that caused adverse geriatric outcomes." @default.
• W3010686323 created "2020-03-23" @default.
• W3010686323 creator A5000191861 @default.
• W3010686323 creator A5005472931 @default.
• W3010686323 creator A5012621720 @default.
• W3010686323 creator A5028161543 @default.
• W3010686323 creator A5035221383 @default.
• W3010686323 creator A5038923785 @default.
• W3010686323 creator A5044537891 @default.
• W3010686323 creator A5059503327 @default.
• W3010686323 creator A5062662633 @default.
• W3010686323 creator A5085552622 @default.
• W3010686323 creator A5086972789 @default.
• W3010686323 date "2020-03-09" @default.
• W3010686323 modified "2023-10-17" @default.
• W3010686323 title "Chronic Polypharmacy with Increasing Drug Burden Index Exacerbates Frailty and Impairs Physical Function, with Effects Attenuated by Deprescribing, in Aged Mice" @default.
• W3010686323 cites W1562992882 @default.
• W3010686323 cites W1771974095 @default.
• W3010686323 cites W1947134347 @default.
• W3010686323 cites W1960796618 @default.
• W3010686323 cites W1963867953 @default.
• W3010686323 cites W1972363175 @default.
• W3010686323 cites W1982360008 @default.
• W3010686323 cites W1985348849 @default.
• W3010686323 cites W2004376628 @default.
• W3010686323 cites W2005979863 @default.
• W3010686323 cites W2010893957 @default.
• W3010686323 cites W2028121853 @default.
• W3010686323 cites W2040213984 @default.
• W3010686323 cites W2054820547 @default.
• W3010686323 cites W2055190898 @default.
• W3010686323 cites W2065844144 @default.
• W3010686323 cites W2070961119 @default.
• W3010686323 cites W2072641978 @default.
• W3010686323 cites W2074318830 @default.
• W3010686323 cites W2081315480 @default.
• W3010686323 cites W2083048709 @default.
• W3010686323 cites W2096114402 @default.
• W3010686323 cites W2108403501 @default.
• W3010686323 cites W2113054165 @default.
• W3010686323 cites W2118277994 @default.
• W3010686323 cites W2126292472 @default.
• W3010686323 cites W2131914658 @default.
• W3010686323 cites W2142514031 @default.
• W3010686323 cites W2143876041 @default.
• W3010686323 cites W2153054970 @default.
• W3010686323 cites W2154395283 @default.
• W3010686323 cites W2155860027 @default.
• W3010686323 cites W2156003677 @default.
• W3010686323 cites W2162670203 @default.
• W3010686323 cites W2167924686 @default.
• W3010686323 cites W2168053015 @default.
• W3010686323 cites W2420049616 @default.
• W3010686323 cites W2557564208 @default.
• W3010686323 cites W2609828520 @default.
• W3010686323 cites W2765386506 @default.
• W3010686323 cites W2766516861 @default.
• W3010686323 cites W2889976868 @default.
• W3010686323 cites W2892465055 @default.
• W3010686323 cites W2912046033 @default.
• W3010686323 cites W2999509442 @default.
• W3010686323 doi "https://doi.org/10.1093/gerona/glaa060" @default.
• W3010686323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8140051" @default.
• W3010686323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32147704" @default.
• W3010686323 hasPublicationYear "2020" @default.
• W3010686323 type Work @default.
• W3010686323 sameAs 3010686323 @default.
• W3010686323 citedByCount "32" @default.
• W3010686323 countsByYear W30106863232020 @default.
• W3010686323 countsByYear W30106863232021 @default.
• W3010686323 countsByYear W30106863232022 @default.
• W3010686323 countsByYear W30106863232023 @default.
• W3010686323 crossrefType "journal-article" @default.
• W3010686323 hasAuthorship W3010686323A5000191861 @default.
• W3010686323 hasAuthorship W3010686323A5005472931 @default.
• W3010686323 hasAuthorship W3010686323A5012621720 @default.
• W3010686323 hasAuthorship W3010686323A5028161543 @default.
• W3010686323 hasAuthorship W3010686323A5035221383 @default.
• W3010686323 hasAuthorship W3010686323A5038923785 @default.
• W3010686323 hasAuthorship W3010686323A5044537891 @default.
• W3010686323 hasAuthorship W3010686323A5059503327 @default.
• W3010686323 hasAuthorship W3010686323A5062662633 @default.
• W3010686323 hasAuthorship W3010686323A5085552622 @default.
• W3010686323 hasAuthorship W3010686323A5086972789 @default.
• W3010686323 hasBestOaLocation W30106863232 @default.
• W3010686323 hasConcept C118552586 @default.
• W3010686323 hasConcept C126322002 @default.
• W3010686323 hasConcept C197934379 @default.
• W3010686323 hasConcept C23131810 @default.
• W3010686323 hasConcept C2776484012 @default.
• W3010686323 hasConcept C2778689640 @default.
• W3010686323 hasConcept C2780035454 @default.
• W3010686323 hasConcept C36434225 @default.
• W3010686323 hasConcept C54183767 @default.
• W3010686323 hasConcept C71924100 @default.
• W3010686323 hasConcept C74909509 @default.
• W3010686323 hasConcept C98274493 @default.
• W3010686323 hasConceptScore W3010686323C118552586 @default.

• next