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• W3010699002 abstract "Inflammation in people living with HIV (PLWH) correlates with severity of HIV-associated neurocognitive disorders. The objective of this study is to identify blood-based markers of neurocognitive function in a demographic balanced cohort of PLWH. Seven neurocognitive domains were evaluated in 121 seropositive Black/African American, Non-Hispanic White, and White Hispanic men and women using computerized assessments. Associations among standardized neurocognitive function and HIV-related parameters, relevant sociodemographic variables, and inflammation-associated cytokines measured in plasma and cellular supernatants were examined using multivariate and univariate regression models. Outlier and covariate analyses were used to identify and normalize for education level, CD4 T cell count, viral load, CNS and drug abuse comorbidities, which could influence biomarker and neurocognitive function associations. Plasma levels of chemokine (C-C motif) ligand (CCL) 8 significantly associated with memory, complex attention, cognitive flexibility, psychomotor speed, executive function, and processing speed. Plasma tissue inhibitor of metalloproteinases 1 associated with the aforementioned domains except memory and processing speed. In addition, plasma interleukin-23 significantly associated with processing speed and executive function. Analysis of peripheral blood cell culture supernatants revealed no significant markers for neurocognitive function. In this cohort, CD4 T cell count and education level also significantly associated with neurocognitive function. All identified inflammatory biomarkers demonstrated a negative correlation to neurocognitive function. These cytokines have known connections to HIV pathophysiology and are potential biomarkers for neurocognitive function in PLWH with promising clinical applications." @default.
• W3010699002 created "2020-03-23" @default.
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• W3010699002 date "2020-03-19" @default.
• W3010699002 modified "2023-09-27" @default.
• W3010699002 title "Blood-based inflammation biomarkers of neurocognitive impairment in people living with HIV" @default.
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• W3010699002 doi "https://doi.org/10.1007/s13365-020-00834-3" @default.
• W3010699002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7332393" @default.
• W3010699002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32193795" @default.
• W3010699002 hasPublicationYear "2020" @default.
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