Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010704764> ?p ?o ?g. }
- W3010704764 abstract "Innate immune cells are the ‘doorkeepers’ in the immune system and are important for the initiation of protective vaccine responses against infection. Being an essential regulatory component of the immune system in these cells, autophagy not only mediates pathogen clearance and cytokine production, but also balances the immune response by preventing harmful overreaction. Interestingly, recent literature indicates that autophagy is positively or negatively regulating the innate immune response in a cell type-specific manner. Moreover, autophagy serves as a bridge between innate and adaptive immunity. It is involved in antigen presentation by delivering pathogen compounds to B and T cells, which is important for effective immune protection. Upon infection, autophagy can also be hijacked by some pathogens for replication or evade host immune responses. As a result, autophagy seems like a double-edged sword to the immune response, strongly depending on the cell types involved and infection models used. In this review, the dual role of autophagy in regulating the immune system will be highlighted in various infection models with particular focus on dendritic cells, monocytes/macrophages and neutrophils. Targeting autophagy in these cells as for therapeutic application or prophylactic vaccination will be discussed considering both roles of autophagy, the ‘angle’ enhancing innate immune responses, antigen presentation, pathogen clearance and dampening inflammation or the ‘demon’ enabling viral replication and degrading innate immune components. A better understanding of this dual potential will help to utilize autophagy in innate immune cells in order to optimize vaccines or treatments against infectious diseases." @default.
- W3010704764 created "2020-03-23" @default.
- W3010704764 creator A5028318993 @default.
- W3010704764 creator A5045557435 @default.
- W3010704764 date "2020-03-19" @default.
- W3010704764 modified "2023-10-04" @default.
- W3010704764 title "Targeting Autophagy in Innate Immune Cells: Angel or Demon During Infection and Vaccination?" @default.
- W3010704764 cites W1523693806 @default.
- W3010704764 cites W1528645406 @default.
- W3010704764 cites W1885941148 @default.
- W3010704764 cites W1968400618 @default.
- W3010704764 cites W1969019747 @default.
- W3010704764 cites W1973314755 @default.
- W3010704764 cites W1979213765 @default.
- W3010704764 cites W1985781825 @default.
- W3010704764 cites W1985902878 @default.
- W3010704764 cites W1989376179 @default.
- W3010704764 cites W1990525844 @default.
- W3010704764 cites W1991692801 @default.
- W3010704764 cites W1991844854 @default.
- W3010704764 cites W1992881494 @default.
- W3010704764 cites W1998068719 @default.
- W3010704764 cites W2005427598 @default.
- W3010704764 cites W2007340000 @default.
- W3010704764 cites W2012451546 @default.
- W3010704764 cites W2019878519 @default.
- W3010704764 cites W2021092016 @default.
- W3010704764 cites W2024028834 @default.
- W3010704764 cites W2042950864 @default.
- W3010704764 cites W2047341425 @default.
- W3010704764 cites W2048030072 @default.
- W3010704764 cites W2052041444 @default.
- W3010704764 cites W2055346100 @default.
- W3010704764 cites W2065031087 @default.
- W3010704764 cites W2067566672 @default.
- W3010704764 cites W2069891242 @default.
- W3010704764 cites W2072621593 @default.
- W3010704764 cites W2074857405 @default.
- W3010704764 cites W2076062022 @default.
- W3010704764 cites W2076649068 @default.
- W3010704764 cites W2080427940 @default.
- W3010704764 cites W2081358375 @default.
- W3010704764 cites W2088140877 @default.
- W3010704764 cites W2088607080 @default.
- W3010704764 cites W2095240020 @default.
- W3010704764 cites W2095371525 @default.
- W3010704764 cites W2097481253 @default.
- W3010704764 cites W2102237050 @default.
- W3010704764 cites W2103644250 @default.
- W3010704764 cites W2104413131 @default.
- W3010704764 cites W2105296171 @default.
- W3010704764 cites W2108660154 @default.
- W3010704764 cites W2120354274 @default.
- W3010704764 cites W2121078059 @default.
- W3010704764 cites W2130350123 @default.
- W3010704764 cites W2132871859 @default.
- W3010704764 cites W2148239390 @default.
- W3010704764 cites W2152051790 @default.
- W3010704764 cites W2155313245 @default.
- W3010704764 cites W2157352436 @default.
- W3010704764 cites W2160310003 @default.
- W3010704764 cites W2161340854 @default.
- W3010704764 cites W2161594732 @default.
- W3010704764 cites W2165098343 @default.
- W3010704764 cites W2172420694 @default.
- W3010704764 cites W2181029113 @default.
- W3010704764 cites W2192964424 @default.
- W3010704764 cites W2221448846 @default.
- W3010704764 cites W2238641150 @default.
- W3010704764 cites W2239321195 @default.
- W3010704764 cites W2268001981 @default.
- W3010704764 cites W2404703480 @default.
- W3010704764 cites W2418163790 @default.
- W3010704764 cites W2442461536 @default.
- W3010704764 cites W2461086044 @default.
- W3010704764 cites W2518266709 @default.
- W3010704764 cites W2521402386 @default.
- W3010704764 cites W2522748004 @default.
- W3010704764 cites W2563511305 @default.
- W3010704764 cites W2563637733 @default.
- W3010704764 cites W2604892093 @default.
- W3010704764 cites W2611360243 @default.
- W3010704764 cites W2621610709 @default.
- W3010704764 cites W2735191646 @default.
- W3010704764 cites W2742558026 @default.
- W3010704764 cites W2742886739 @default.
- W3010704764 cites W2748813793 @default.
- W3010704764 cites W2762765675 @default.
- W3010704764 cites W2764322409 @default.
- W3010704764 cites W2765095758 @default.
- W3010704764 cites W2769978044 @default.
- W3010704764 cites W2776614535 @default.
- W3010704764 cites W2777816879 @default.
- W3010704764 cites W2789111316 @default.
- W3010704764 cites W2794396490 @default.
- W3010704764 cites W2796061259 @default.
- W3010704764 cites W2802309637 @default.
- W3010704764 cites W2894816987 @default.
- W3010704764 cites W2900700012 @default.
- W3010704764 cites W2900905513 @default.