FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010711938> ?p ?o ?g. }

• W3010711938 endingPage "316" @default.
• W3010711938 startingPage "309" @default.
• W3010711938 abstract "As a central pro-inflammatory cytokine, interleukin-1β (IL-1β) plays critical roles in the inflammatory response, pathogen infection, and immunological challenges in mammals. Although fish IL-1β has been confirmed to participate in inflammatory response to pathogen infection, few studies have been performed to characterize the antibacterial and bactericidal functions of fish IL-1β. In this study, snakehead (Channa argus) IL-1β (shIL-1β) and its receptors, shIL-1R1 and shIL-1R2, were cloned and functionally characterized. ShIL-1β contained the IL-1 family signature domain, and a potential cutting site at Asp96 that presented in all vertebrate IL-1β sequences. ShIL-1R1 had three extracellular IG-like domains and one intracellular signal TIR domain, while shIL-1R2 had three extracellular IG-like domain but lacked the intracellular signal TIR domain. ShIL-1β, shIL-1R1, and shIL-1R2 were constitutively expressed in all tested tissues, and their expressions could be induced by Aeromonas schubertii and Nocardia seriolae in the head kidney and spleen in vivo, and by LTA, LPS, and Poly (I:C) in head kidney leukocytes (HKLs) in vitro. Moreover, recombinant shIL-1β upregulated the expression of endogenous shIL-1β, shIL-R1, and shIL-R2 in snakehead HKLs, and enhanced intracellular bactericidal activity. Taken together, this study found that, like IL-1β and its receptors in mammals, shIL-1β and its receptors play crucial roles in antibacterial innate immunity. This provides new insight into the evolution of IL-1β function in vertebrates." @default.
• W3010711938 created "2020-03-23" @default.
• W3010711938 creator A5030563375 @default.
• W3010711938 creator A5050943129 @default.
• W3010711938 creator A5059033429 @default.
• W3010711938 creator A5060851348 @default.
• W3010711938 creator A5072852596 @default.
• W3010711938 creator A5075688227 @default.
• W3010711938 date "2020-05-01" @default.
• W3010711938 modified "2023-09-25" @default.
• W3010711938 title "Bacteria-induced IL-1β and its receptors in snakehead (Channa argus): Evidence for their involvement in antibacterial innate immunity" @default.
• W3010711938 cites W1522206572 @default.
• W3010711938 cites W1596310973 @default.
• W3010711938 cites W1613736574 @default.
• W3010711938 cites W1884485387 @default.
• W3010711938 cites W1963763015 @default.
• W3010711938 cites W1966090924 @default.
• W3010711938 cites W1969461218 @default.
• W3010711938 cites W1973216058 @default.
• W3010711938 cites W1979799173 @default.
• W3010711938 cites W1980748692 @default.
• W3010711938 cites W1981755124 @default.
• W3010711938 cites W1990775730 @default.
• W3010711938 cites W1998145026 @default.
• W3010711938 cites W2002996618 @default.
• W3010711938 cites W2005475669 @default.
• W3010711938 cites W2007232879 @default.
• W3010711938 cites W2023403017 @default.
• W3010711938 cites W2036047612 @default.
• W3010711938 cites W2051329301 @default.
• W3010711938 cites W2055727949 @default.
• W3010711938 cites W2072845223 @default.
• W3010711938 cites W2075685652 @default.
• W3010711938 cites W2091318049 @default.
• W3010711938 cites W2091843987 @default.
• W3010711938 cites W2093338753 @default.
• W3010711938 cites W2094942139 @default.
• W3010711938 cites W2095090055 @default.
• W3010711938 cites W2099806775 @default.
• W3010711938 cites W2109126129 @default.
• W3010711938 cites W2110318063 @default.
• W3010711938 cites W2137337213 @default.
• W3010711938 cites W2145866317 @default.
• W3010711938 cites W2150107812 @default.
• W3010711938 cites W2153699751 @default.
• W3010711938 cites W2157650174 @default.
• W3010711938 cites W2162760851 @default.
• W3010711938 cites W2165275387 @default.
• W3010711938 cites W2172033086 @default.
• W3010711938 cites W2587763588 @default.
• W3010711938 cites W2802012976 @default.
• W3010711938 cites W2883200519 @default.
• W3010711938 cites W2987088228 @default.
• W3010711938 cites W949182978 @default.
• W3010711938 doi "https://doi.org/10.1016/j.fsi.2020.03.022" @default.
• W3010711938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32173451" @default.
• W3010711938 hasPublicationYear "2020" @default.
• W3010711938 type Work @default.
• W3010711938 sameAs 3010711938 @default.
• W3010711938 citedByCount "13" @default.
• W3010711938 countsByYear W30107119382020 @default.
• W3010711938 countsByYear W30107119382021 @default.
• W3010711938 countsByYear W30107119382022 @default.
• W3010711938 countsByYear W30107119382023 @default.
• W3010711938 crossrefType "journal-article" @default.
• W3010711938 hasAuthorship W3010711938A5030563375 @default.
• W3010711938 hasAuthorship W3010711938A5050943129 @default.
• W3010711938 hasAuthorship W3010711938A5059033429 @default.
• W3010711938 hasAuthorship W3010711938A5060851348 @default.
• W3010711938 hasAuthorship W3010711938A5072852596 @default.
• W3010711938 hasAuthorship W3010711938A5075688227 @default.
• W3010711938 hasConcept C136449434 @default.
• W3010711938 hasConcept C170493617 @default.
• W3010711938 hasConcept C203014093 @default.
• W3010711938 hasConcept C28406088 @default.
• W3010711938 hasConcept C55493867 @default.
• W3010711938 hasConcept C86803240 @default.
• W3010711938 hasConcept C89423630 @default.
• W3010711938 hasConcept C95444343 @default.
• W3010711938 hasConceptScore W3010711938C136449434 @default.
• W3010711938 hasConceptScore W3010711938C170493617 @default.
• W3010711938 hasConceptScore W3010711938C203014093 @default.
• W3010711938 hasConceptScore W3010711938C28406088 @default.
• W3010711938 hasConceptScore W3010711938C55493867 @default.
• W3010711938 hasConceptScore W3010711938C86803240 @default.
• W3010711938 hasConceptScore W3010711938C89423630 @default.
• W3010711938 hasConceptScore W3010711938C95444343 @default.
• W3010711938 hasFunder F4320321001 @default.
• W3010711938 hasFunder F4320321921 @default.
• W3010711938 hasFunder F4320335447 @default.
• W3010711938 hasLocation W30107119381 @default.
• W3010711938 hasOpenAccess W3010711938 @default.
• W3010711938 hasPrimaryLocation W30107119381 @default.
• W3010711938 hasRelatedWork W1960850474 @default.
• W3010711938 hasRelatedWork W2000561387 @default.
• W3010711938 hasRelatedWork W2015707024 @default.
• W3010711938 hasRelatedWork W2084474801 @default.
• W3010711938 hasRelatedWork W2166671868 @default.

• next