Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010748436> ?p ?o ?g. }
- W3010748436 abstract "Abstract The positive or negative value (valence) of past experiences is normally integrated into neuronal circuits that encode episodic memories and plays an important role in guiding behavior. Here, we show, using mouse behavioral models, that glutamatergic afferents from the ventral tegmental area to the dorsal hippocampus (VTA→DH) signal negative valence to memory circuits, leading to the formation of fear-inducing context memories and to context-specific reinstatement of fear. To a lesser extent, these projections also contributed to opioid-induced place preference, suggesting a role in signaling positive valence as well, and thus a lack of dedicated polarity. Manipulations of VTA terminal activity were more effective in females and paralleled by sex differences in glutamatergic signaling. By prioritizing retrieval of negative and positive over neutral memories, the VTA→DH circuit can facilitate the selection of adaptive behaviors when current and past experiences are valence congruent." @default.
- W3010748436 created "2020-03-23" @default.
- W3010748436 creator A5000988147 @default.
- W3010748436 creator A5009109800 @default.
- W3010748436 creator A5013941218 @default.
- W3010748436 creator A5017456629 @default.
- W3010748436 creator A5020177179 @default.
- W3010748436 creator A5029419416 @default.
- W3010748436 creator A5029897160 @default.
- W3010748436 creator A5033698713 @default.
- W3010748436 creator A5033742239 @default.
- W3010748436 creator A5050062709 @default.
- W3010748436 creator A5055102546 @default.
- W3010748436 creator A5055139782 @default.
- W3010748436 creator A5066937301 @default.
- W3010748436 creator A5071014600 @default.
- W3010748436 creator A5079394537 @default.
- W3010748436 creator A5091203828 @default.
- W3010748436 creator A5091649475 @default.
- W3010748436 date "2020-03-19" @default.
- W3010748436 modified "2023-10-18" @default.
- W3010748436 title "Excitatory VTA to DH projections provide a valence signal to memory circuits" @default.
- W3010748436 cites W1187096858 @default.
- W3010748436 cites W1767661185 @default.
- W3010748436 cites W1982578342 @default.
- W3010748436 cites W1984005657 @default.
- W3010748436 cites W1988193487 @default.
- W3010748436 cites W1989745917 @default.
- W3010748436 cites W1993690326 @default.
- W3010748436 cites W1997065612 @default.
- W3010748436 cites W1997679949 @default.
- W3010748436 cites W2000721883 @default.
- W3010748436 cites W2004002023 @default.
- W3010748436 cites W2005599916 @default.
- W3010748436 cites W2008858126 @default.
- W3010748436 cites W2017814058 @default.
- W3010748436 cites W2024049038 @default.
- W3010748436 cites W2032950480 @default.
- W3010748436 cites W2033080466 @default.
- W3010748436 cites W2034154165 @default.
- W3010748436 cites W2034786388 @default.
- W3010748436 cites W2036681307 @default.
- W3010748436 cites W2040574649 @default.
- W3010748436 cites W2045821490 @default.
- W3010748436 cites W2047892647 @default.
- W3010748436 cites W2051719689 @default.
- W3010748436 cites W2061072142 @default.
- W3010748436 cites W2065847146 @default.
- W3010748436 cites W2066719328 @default.
- W3010748436 cites W2066848874 @default.
- W3010748436 cites W2073461968 @default.
- W3010748436 cites W2073564837 @default.
- W3010748436 cites W2075455407 @default.
- W3010748436 cites W2078047435 @default.
- W3010748436 cites W2090169982 @default.
- W3010748436 cites W2100193366 @default.
- W3010748436 cites W2107525024 @default.
- W3010748436 cites W2110659025 @default.
- W3010748436 cites W2112054094 @default.
- W3010748436 cites W2120207805 @default.
- W3010748436 cites W2121007598 @default.
- W3010748436 cites W2128156437 @default.
- W3010748436 cites W2129387324 @default.
- W3010748436 cites W2131462031 @default.
- W3010748436 cites W2136916973 @default.
- W3010748436 cites W2140257430 @default.
- W3010748436 cites W2153462407 @default.
- W3010748436 cites W2153998371 @default.
- W3010748436 cites W2156894810 @default.
- W3010748436 cites W2184138621 @default.
- W3010748436 cites W2211535413 @default.
- W3010748436 cites W2239601698 @default.
- W3010748436 cites W2286410651 @default.
- W3010748436 cites W2419550169 @default.
- W3010748436 cites W2508644210 @default.
- W3010748436 cites W2509099448 @default.
- W3010748436 cites W2513677007 @default.
- W3010748436 cites W2555970512 @default.
- W3010748436 cites W2560490590 @default.
- W3010748436 cites W2567343056 @default.
- W3010748436 cites W2569240731 @default.
- W3010748436 cites W2582553065 @default.
- W3010748436 cites W2594961991 @default.
- W3010748436 cites W2607295080 @default.
- W3010748436 cites W2742880676 @default.
- W3010748436 cites W2744000261 @default.
- W3010748436 cites W2766334411 @default.
- W3010748436 cites W2795417916 @default.
- W3010748436 cites W2806492982 @default.
- W3010748436 cites W2898598973 @default.
- W3010748436 cites W2912151704 @default.
- W3010748436 cites W4245337313 @default.
- W3010748436 doi "https://doi.org/10.1038/s41467-020-15035-z" @default.
- W3010748436 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7081331" @default.
- W3010748436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32193428" @default.
- W3010748436 hasPublicationYear "2020" @default.
- W3010748436 type Work @default.
- W3010748436 sameAs 3010748436 @default.
- W3010748436 citedByCount "18" @default.
- W3010748436 countsByYear W30107484362020 @default.