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- W3010752007 abstract "Head and Neck Squamous Cell Carcinomas (HNSCC) are a heterogenous group of cancers formed in squamous epithelial cells. In a few HNSCC, the cancer is developed because of long-term viral infection. Carcinomas of the Oropharynx (OPSCC) have a high rate of infection of Human Papilloma Virus (HPV), where tonsils (TSCC) have the highest. The aim of this thesis was to evaluate differential expression between HPV+/- TSCC patients, and how it relates to a CD8+ T-cell mediated immune response. Two independent gene sets were used to divide patients into HPV- and HPV+ groups in a TSCC RNA-Seq dataset from The human Cancer Genome Atlas (TCGA). After differential expression analysis the findings were validated by flow cytometry. The results of this study suggest that HPV+ samples have more CD8+ T-cells present in the tumour compared to HPV- samples, and that the same is true for conventional type 1 dendritic cells (cDC1). This supports the importance of antigen processing and presentation capacity of cDCs for an efficient T-cell mediated anti-tumour adaptive immune response. Two candidate genes, X and Y, were correlated to both CD8+ T-cell and cDC1 presence in the tumour. These candidates were expressed in cDCs along with a wide variety of cell types. In conclusion, the results suggest that there is a difference in expression of cDC1-related biomarkers between HPV+ and HPV- TSCC samples, which could be related to CD8+ T-cell abundance and infiltration. Genes X and Y were both expressed in healthy tonsils, confirmed by flow cytometry, and are suitable markers for functional studies. (Less)" @default.
- W3010752007 created "2020-03-23" @default.
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- W3010752007 date "2020-01-01" @default.
- W3010752007 modified "2023-09-27" @default.
- W3010752007 title "Biomarkers linking cross-presenting cDCs to infiltration of CD8+ T-cells in HPV+ tonsillar squamous cell carcinoma" @default.
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