Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010756543> ?p ?o ?g. }
- W3010756543 endingPage "e0119" @default.
- W3010756543 startingPage "e0119" @default.
- W3010756543 abstract "Background: Cerebral palsy (CP) is the most common cause of childhood disability globally. Botulinum toxin A injections are widely used to manage limb spasticity in children with CP. Intramuscular botulinum toxin A has been used in the upper limbs of children with CP to manage preoperative and postoperative pain, facilitate nursing, and achieve functional and/or cosmetic improvement of hand position. These goals are achieved primarily through reduction of spasticity. The aim of this review was to assess the evidence for the effect of botulinum toxin A injections used to manage upper limb spasticity in children with spastic CP. Specifically, we examined the role of botulinum toxin A as an adjunctive treatment to other physical therapy modalities. Additionally, we analyzed the associated complications. Methods: The literature extraction process involved 4 phases: identification, screening, eligibility, and inclusion. We used a combination of Google Scholar, PubMed, and ScienceDirect. The choice of the search terms was based on the Medical Subject Headings. We extracted the relevant studies using a combination of words or terms related to (1) patient population, (2) pathology, (3) clinical intervention, and (4) anatomical distribution of pathology. Studies were included if they were randomized controlled trials conducted on children and/or adolescents with CP targeting the upper extremities in which botulinum toxin A was used as an adjunctive treatment to a primary intervention. Results: The literature extraction process yielded 15 randomized controlled trials for inclusion in this review. The total number of participants enrolled in the included studies was 499, with 255 in the intervention group (51%) and 244 controls (49%). All participants in the eligible studies had unilateral spastic CP except for those in 4 studies (27%) with 198 participants (40%) that included a heterogeneous sample of unilateral and bilateral spastic CP. The mean age of participants in the intervention group ranged from 2.6 to 10.7 years among the individual studies. The mean age of participants in the control group ranged from 3.1 to 10.55 years among the individual studies. This review indicated that botulinum toxin A had a positive effect on the degree of spasticity and cosmetic appearance of the injected upper limb. The results with respect to functional gains and quality of life were either conflicting or not significant. Conclusions: Randomized controlled trials of botulinum toxin A injection in the treatment of upper limb spasticity in children with CP used variable outcome measures and yielded mixed results. Overall, there is some evidence to support the use of botulinum toxin A as an adjuvant treatment to other physical therapy regimens or placebo to reduce spasticity in the short term. There is insufficient evidence to support its use as an adjunctive treatment to improve upper limb function or quality of life. The complications were acceptable and did not outweigh the clinical gains incurred. Level of Evidence: Therapeutic Level I . See Instructions for Authors for a complete description of levels of evidence." @default.
- W3010756543 created "2020-03-23" @default.
- W3010756543 creator A5020787957 @default.
- W3010756543 creator A5033227086 @default.
- W3010756543 creator A5036271867 @default.
- W3010756543 creator A5037724124 @default.
- W3010756543 creator A5090424529 @default.
- W3010756543 date "2020-03-01" @default.
- W3010756543 modified "2023-10-17" @default.
- W3010756543 title "Botulinum Toxin A Injection in Treatment of Upper Limb Spasticity in Children with Cerebral Palsy" @default.
- W3010756543 cites W1574925014 @default.
- W3010756543 cites W1784553336 @default.
- W3010756543 cites W1979039354 @default.
- W3010756543 cites W1981027559 @default.
- W3010756543 cites W1984789295 @default.
- W3010756543 cites W1986215651 @default.
- W3010756543 cites W1993862049 @default.
- W3010756543 cites W2002551695 @default.
- W3010756543 cites W2007977734 @default.
- W3010756543 cites W2011492941 @default.
- W3010756543 cites W2015033575 @default.
- W3010756543 cites W2037828289 @default.
- W3010756543 cites W2041921635 @default.
- W3010756543 cites W2042710347 @default.
- W3010756543 cites W2055804579 @default.
- W3010756543 cites W2056553377 @default.
- W3010756543 cites W2086622214 @default.
- W3010756543 cites W2103035948 @default.
- W3010756543 cites W2103589991 @default.
- W3010756543 cites W2105955760 @default.
- W3010756543 cites W2118450347 @default.
- W3010756543 cites W2142171035 @default.
- W3010756543 cites W2150384337 @default.
- W3010756543 cites W2160898908 @default.
- W3010756543 cites W2169205464 @default.
- W3010756543 cites W2172120951 @default.
- W3010756543 cites W2285910398 @default.
- W3010756543 cites W2292818836 @default.
- W3010756543 cites W2337108558 @default.
- W3010756543 cites W2553396622 @default.
- W3010756543 cites W2580307046 @default.
- W3010756543 cites W2770887120 @default.
- W3010756543 cites W2793566477 @default.
- W3010756543 cites W2801075478 @default.
- W3010756543 cites W2810343298 @default.
- W3010756543 cites W2811502152 @default.
- W3010756543 cites W2883043489 @default.
- W3010756543 cites W2886924144 @default.
- W3010756543 cites W2888096444 @default.
- W3010756543 cites W2899168213 @default.
- W3010756543 cites W2917383547 @default.
- W3010756543 doi "https://doi.org/10.2106/jbjs.rvw.19.00119" @default.
- W3010756543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7161716" @default.
- W3010756543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32224633" @default.
- W3010756543 hasPublicationYear "2020" @default.
- W3010756543 type Work @default.
- W3010756543 sameAs 3010756543 @default.
- W3010756543 citedByCount "17" @default.
- W3010756543 countsByYear W30107565432020 @default.
- W3010756543 countsByYear W30107565432021 @default.
- W3010756543 countsByYear W30107565432022 @default.
- W3010756543 countsByYear W30107565432023 @default.
- W3010756543 crossrefType "journal-article" @default.
- W3010756543 hasAuthorship W3010756543A5020787957 @default.
- W3010756543 hasAuthorship W3010756543A5033227086 @default.
- W3010756543 hasAuthorship W3010756543A5036271867 @default.
- W3010756543 hasAuthorship W3010756543A5037724124 @default.
- W3010756543 hasAuthorship W3010756543A5090424529 @default.
- W3010756543 hasBestOaLocation W30107565431 @default.
- W3010756543 hasConcept C141071460 @default.
- W3010756543 hasConcept C168563851 @default.
- W3010756543 hasConcept C1862650 @default.
- W3010756543 hasConcept C2776195251 @default.
- W3010756543 hasConcept C2777478456 @default.
- W3010756543 hasConcept C2779012798 @default.
- W3010756543 hasConcept C2779421357 @default.
- W3010756543 hasConcept C2908647359 @default.
- W3010756543 hasConcept C71924100 @default.
- W3010756543 hasConcept C99454951 @default.
- W3010756543 hasConcept C99508421 @default.
- W3010756543 hasConceptScore W3010756543C141071460 @default.
- W3010756543 hasConceptScore W3010756543C168563851 @default.
- W3010756543 hasConceptScore W3010756543C1862650 @default.
- W3010756543 hasConceptScore W3010756543C2776195251 @default.
- W3010756543 hasConceptScore W3010756543C2777478456 @default.
- W3010756543 hasConceptScore W3010756543C2779012798 @default.
- W3010756543 hasConceptScore W3010756543C2779421357 @default.
- W3010756543 hasConceptScore W3010756543C2908647359 @default.
- W3010756543 hasConceptScore W3010756543C71924100 @default.
- W3010756543 hasConceptScore W3010756543C99454951 @default.
- W3010756543 hasConceptScore W3010756543C99508421 @default.
- W3010756543 hasIssue "3" @default.
- W3010756543 hasLocation W30107565431 @default.
- W3010756543 hasLocation W30107565432 @default.
- W3010756543 hasLocation W30107565433 @default.
- W3010756543 hasLocation W30107565434 @default.
- W3010756543 hasOpenAccess W3010756543 @default.
- W3010756543 hasPrimaryLocation W30107565431 @default.