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- W3010772470 endingPage "757" @default.
- W3010772470 startingPage "757" @default.
- W3010772470 abstract "Ataxia is a neurodegenerative syndrome, which can emerge as a major element of a disease or represent a symptom of more complex multisystemic disorders. It comprises several forms with a highly variegated etiology, mainly united by motor, balance, and speech impairments and, at the tissue level, by cerebellar atrophy and Purkinje cells degeneration. For this reason, the contribution of astrocytes to this disease has been largely overlooked in the past. Nevertheless, in the last few decades, growing evidences are pointing to cerebellar astrocytes as crucial players not only in the progression but also in the onset of distinct forms of ataxia. Although the current knowledge on this topic is very fragmentary and ataxia type-specific, the present review will attempt to provide a comprehensive view of astrocytes’ involvement across the distinct forms of this pathology. Here, it will be highlighted how, through consecutive stage-specific mechanisms, astrocytes can lead to non-cell autonomous neurodegeneration and, consequently, to the behavioral impairments typical of this disease. In light of that, treating astrocytes to heal neurons will be discussed as a potential complementary therapeutic approach for ataxic patients, a crucial point provided the absence of conclusive treatments for this disease." @default.
- W3010772470 created "2020-03-23" @default.
- W3010772470 creator A5028057298 @default.
- W3010772470 date "2020-03-11" @default.
- W3010772470 modified "2023-10-14" @default.
- W3010772470 title "Cerebellar Astrocytes: Much More Than Passive Bystanders In Ataxia Pathophysiology" @default.
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