FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010787917> ?p ?o ?g. }

• W3010787917 endingPage "1398" @default.
• W3010787917 startingPage "1391" @default.
• W3010787917 abstract "The amino acid serine is an important substrate for biosynthesis and redox homeostasis. We investigated whether glioblastoma (GBM) cells are dependent on serine for survival under conditions of the tumour microenvironment.Serine availability in GBM cells was modulated pharmacologically, genetically and by adjusting serine and glycine concentrations in the culture medium. Cells were investigated for regulation of serine metabolism, proliferation, sensitivity to hypoxia-induced cell death and redox homeostasis.Hypoxia-induced expression of phosphoglycerate dehydrogenase (PHGDH) and the mitochondrial serine hydroxymethyltransferase (SHMT2) was observed in three of five tested glioma cell lines. Nuclear factor erythroid 2-related factor (Nrf) 2 activation also induced PHGDH and SHMT2 expression in GBM cells. Low levels of endogenous PHGDH as well as PHGDH gene suppression resulted in serine dependency for cell growth. Pharmacological inhibition of PHGDH with CBR-5884 reduced proliferation and sensitised cells profoundly to hypoxia-induced cell death. This effect was accompanied by an increase in reactive oxygen species and a decrease in the NADPH/NADP+ ratio. Similarly, hypoxia-induced cell death was enhanced by PHGDH gene suppression and reduced by PHGDH overexpression.Serine facilitates adaptation of GBM cells to conditions of the tumour microenvironment and its metabolism could be a plausible therapeutic target." @default.
• W3010787917 created "2020-03-23" @default.
• W3010787917 creator A5012478165 @default.
• W3010787917 creator A5014445320 @default.
• W3010787917 creator A5018037671 @default.
• W3010787917 creator A5018892170 @default.
• W3010787917 creator A5029955942 @default.
• W3010787917 creator A5050421652 @default.
• W3010787917 creator A5064141082 @default.
• W3010787917 creator A5076567865 @default.
• W3010787917 date "2020-03-17" @default.
• W3010787917 modified "2023-10-13" @default.
• W3010787917 title "Serine-dependent redox homeostasis regulates glioblastoma cell survival" @default.
• W3010787917 cites W1578284256 @default.
• W3010787917 cites W1608124346 @default.
• W3010787917 cites W1975753895 @default.
• W3010787917 cites W1980181091 @default.
• W3010787917 cites W1993238514 @default.
• W3010787917 cites W1998976898 @default.
• W3010787917 cites W2020498032 @default.
• W3010787917 cites W2022643459 @default.
• W3010787917 cites W2022899908 @default.
• W3010787917 cites W2024516693 @default.
• W3010787917 cites W2031484695 @default.
• W3010787917 cites W2038032067 @default.
• W3010787917 cites W2040113269 @default.
• W3010787917 cites W2051522090 @default.
• W3010787917 cites W2064358530 @default.
• W3010787917 cites W2066963700 @default.
• W3010787917 cites W2078369395 @default.
• W3010787917 cites W2082654353 @default.
• W3010787917 cites W2082959665 @default.
• W3010787917 cites W2087987448 @default.
• W3010787917 cites W2093391702 @default.
• W3010787917 cites W2096287682 @default.
• W3010787917 cites W2096468684 @default.
• W3010787917 cites W2097259163 @default.
• W3010787917 cites W2108195113 @default.
• W3010787917 cites W2109290727 @default.
• W3010787917 cites W2110711017 @default.
• W3010787917 cites W2117692326 @default.
• W3010787917 cites W2123894943 @default.
• W3010787917 cites W2125257427 @default.
• W3010787917 cites W2126524529 @default.
• W3010787917 cites W2137470659 @default.
• W3010787917 cites W2139595663 @default.
• W3010787917 cites W2145806440 @default.
• W3010787917 cites W2148977460 @default.
• W3010787917 cites W2149932734 @default.
• W3010787917 cites W2155105887 @default.
• W3010787917 cites W2173466127 @default.
• W3010787917 cites W2266570683 @default.
• W3010787917 cites W2323026550 @default.
• W3010787917 cites W2343452853 @default.
• W3010787917 cites W2345696077 @default.
• W3010787917 cites W2418570604 @default.
• W3010787917 cites W2548361432 @default.
• W3010787917 cites W2624969848 @default.
• W3010787917 cites W2744571323 @default.
• W3010787917 cites W2760560019 @default.
• W3010787917 cites W2761245997 @default.
• W3010787917 cites W2768515496 @default.
• W3010787917 cites W2778283729 @default.
• W3010787917 cites W2803899003 @default.
• W3010787917 cites W2886742833 @default.
• W3010787917 cites W2898994124 @default.
• W3010787917 cites W2923083564 @default.
• W3010787917 cites W2941527610 @default.
• W3010787917 cites W2980925374 @default.
• W3010787917 cites W4234865248 @default.
• W3010787917 cites W45983178 @default.
• W3010787917 doi "https://doi.org/10.1038/s41416-020-0794-x" @default.
• W3010787917 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7188854" @default.
• W3010787917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32203214" @default.
• W3010787917 hasPublicationYear "2020" @default.
• W3010787917 type Work @default.
• W3010787917 sameAs 3010787917 @default.
• W3010787917 citedByCount "36" @default.
• W3010787917 countsByYear W30107879172020 @default.
• W3010787917 countsByYear W30107879172021 @default.
• W3010787917 countsByYear W30107879172022 @default.
• W3010787917 countsByYear W30107879172023 @default.
• W3010787917 crossrefType "journal-article" @default.
• W3010787917 hasAuthorship W3010787917A5012478165 @default.
• W3010787917 hasAuthorship W3010787917A5014445320 @default.
• W3010787917 hasAuthorship W3010787917A5018037671 @default.
• W3010787917 hasAuthorship W3010787917A5018892170 @default.
• W3010787917 hasAuthorship W3010787917A5029955942 @default.
• W3010787917 hasAuthorship W3010787917A5050421652 @default.
• W3010787917 hasAuthorship W3010787917A5064141082 @default.
• W3010787917 hasAuthorship W3010787917A5076567865 @default.
• W3010787917 hasBestOaLocation W30107879171 @default.
• W3010787917 hasConcept C11960822 @default.
• W3010787917 hasConcept C16613235 @default.
• W3010787917 hasConcept C190283241 @default.
• W3010787917 hasConcept C2776414213 @default.
• W3010787917 hasConcept C2777756961 @default.
• W3010787917 hasConcept C2779932687 @default.

• next