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• W3010802223 abstract "Abstract Insulin resistance is associated with aging in mice and humans. We have previously shown that administration of recombinant GDF11 (rGDF11) to aged mice alters aging phenotypes in the brain, skeletal muscle, and heart. While the closely related protein GDF8 has a role in metabolism, limited data are available on the potential metabolic effects of GDF11 or GDF8 in aging. To determine the metabolic effects of these two ligands, we administered rGDF11 or rGDF8 protein to young or aged mice fed a standard chow diet, short-term high-fat diet (HFD), or long-term HFD. Under nearly all of these diet conditions, administration of exogenous rGDF11 reduced body weight by 3–17% and significantly improved glucose tolerance in aged mice fed a chow (~30% vs. saline) or HF (~50% vs. saline) diet and young mice fed a HFD (~30%). On the other hand, exogenous rGDF8 showed signifcantly lesser effect or no effect at all on glucose tolerance compared to rGDF11, consistent with data demonstrating that GFD11 is a more potent signaling ligand than GDF8. Collectively, our results show that administration of exogenous rGDF11, but not rGDF8, can reduce diet-induced weight gain and improve metabolic homeostasis." @default.
• W3010802223 created "2020-03-23" @default.
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• W3010802223 date "2020-03-12" @default.
• W3010802223 modified "2023-10-01" @default.
• W3010802223 title "Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice" @default.
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• W3010802223 doi "https://doi.org/10.1038/s41598-020-61443-y" @default.
• W3010802223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7067781" @default.
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