FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010803776> ?p ?o ?g. }

• W3010803776 endingPage "372.e7" @default.
• W3010803776 startingPage "372.e1" @default.
• W3010803776 abstract "<h2>Summary</h2><h3>Background</h3> The epidemiology and risk factors for paediatric urolithiasis (UL) in developed countries are evolving, with increasing rates of metabolic stone-formers. In the United Kingdom (UK), only a single London cohort has been studied in the past three decades. Regional disease patterns across the UK remain unknown. UL has been associated with an increased risk of chronic kidney disease in adults, but long-term paediatric outcomes remain poorly understood. <h3>Methods</h3> We assessed the epidemiology of paediatric UL by defining the demographics, incidence, aetiology, recurrence rates and outcomes at tertiary nephro-urology centres in Greater Manchester. Health records of 177 consecutive paediatric urology referrals (0–18 years) for UL between 2002 and 2015 were retrospectively included for observational analysis. Metabolic screening was performed in 105 children. <h3>Results</h3> The incidence of paediatric urology referrals for UL was 1.77/100,000 person-years, increasing annually by 13.6%. Mean patient age was 8.2 years and the male:female ratio was 1.3:1. The upper urinary tract was involved in more than 90% of cases and 45% of children presented with multiple calculi. Metabolic abnormalities were identified in 52% of children screened: hypercalciuria (64%), hyperoxaluria (18%) and cystinuria (11%) were the most common. Significant family history was predictive of metabolic abnormalities (OR 4.9:1, 95% CI 1.4–17.0). 30% of children had infective stones, which were more common in children less than 6 years. Ultrasound was found to be 90% sensitive for UL detection. Dimercaptosuccinic acid (DMSA) imaging identified renal scarring in 33 of the 55 children tested (60%). Recurrence was observed in 18% of children over mean 6.4 year follow-up and was more common in metabolic stone-formers. Spontaneous passage was observed in 83% of stones ≤ 5 mm, 69% between 5 and 10 mm and only one calculi > 10 mm. <h3>Conclusions</h3> The incidence of paediatric urology referrals for UL is rising in North West England. Metabolic abnormalities were detected in half of the children tested, justifying comprehensive screening. Recurrence is common following paediatric UL, reinforcing the need for stone prevention strategies. The majority of calculi less than 10 mm were found to pass spontaneously with supportive measures, which favours an initial observation period over surgical intervention for small calculi. UL was associated with renal scarring in the analysed population and therefore, children with UL require long-term assessment of blood pressure and proteinuria.Figure – Aetiological classification: by age. (A) Males (n = 58). (B) Females (n = 47)." @default.
• W3010803776 created "2020-03-23" @default.
• W3010803776 creator A5022797938 @default.
• W3010803776 creator A5037989508 @default.
• W3010803776 creator A5072277459 @default.
• W3010803776 date "2020-06-01" @default.
• W3010803776 modified "2023-09-24" @default.
• W3010803776 title "No stone unturned: The epidemiology and outcomes of paediatric urolithiasis in Manchester, United Kingdom" @default.
• W3010803776 cites W1243163843 @default.
• W3010803776 cites W1965486595 @default.
• W3010803776 cites W1970861258 @default.
• W3010803776 cites W1973604580 @default.
• W3010803776 cites W1992121180 @default.
• W3010803776 cites W1997933873 @default.
• W3010803776 cites W2004233132 @default.
• W3010803776 cites W2012063813 @default.
• W3010803776 cites W2017551024 @default.
• W3010803776 cites W2022850041 @default.
• W3010803776 cites W2027358243 @default.
• W3010803776 cites W2032638090 @default.
• W3010803776 cites W2033362556 @default.
• W3010803776 cites W2043057816 @default.
• W3010803776 cites W2046908545 @default.
• W3010803776 cites W2060968069 @default.
• W3010803776 cites W2073468331 @default.
• W3010803776 cites W2080072556 @default.
• W3010803776 cites W2083110940 @default.
• W3010803776 cites W2130067314 @default.
• W3010803776 cites W2134786042 @default.
• W3010803776 cites W2137231931 @default.
• W3010803776 cites W2141096424 @default.
• W3010803776 cites W2149105198 @default.
• W3010803776 cites W2159419421 @default.
• W3010803776 cites W2171697262 @default.
• W3010803776 cites W2593015162 @default.
• W3010803776 cites W2607128961 @default.
• W3010803776 cites W2795635259 @default.
• W3010803776 doi "https://doi.org/10.1016/j.jpurol.2020.03.009" @default.
• W3010803776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32249190" @default.
• W3010803776 hasPublicationYear "2020" @default.
• W3010803776 type Work @default.
• W3010803776 sameAs 3010803776 @default.
• W3010803776 citedByCount "8" @default.
• W3010803776 countsByYear W30108037762021 @default.
• W3010803776 countsByYear W30108037762022 @default.
• W3010803776 countsByYear W30108037762023 @default.
• W3010803776 crossrefType "journal-article" @default.
• W3010803776 hasAuthorship W3010803776A5022797938 @default.
• W3010803776 hasAuthorship W3010803776A5037989508 @default.
• W3010803776 hasAuthorship W3010803776A5072277459 @default.
• W3010803776 hasConcept C107130276 @default.
• W3010803776 hasConcept C120665830 @default.
• W3010803776 hasConcept C121332964 @default.
• W3010803776 hasConcept C126322002 @default.
• W3010803776 hasConcept C181199279 @default.
• W3010803776 hasConcept C185592680 @default.
• W3010803776 hasConcept C187212893 @default.
• W3010803776 hasConcept C2776608514 @default.
• W3010803776 hasConcept C2777608289 @default.
• W3010803776 hasConcept C2777724520 @default.
• W3010803776 hasConcept C2779201268 @default.
• W3010803776 hasConcept C2781179581 @default.
• W3010803776 hasConcept C55493867 @default.
• W3010803776 hasConcept C61511704 @default.
• W3010803776 hasConcept C71924100 @default.
• W3010803776 hasConcept C72563966 @default.
• W3010803776 hasConcept C77411442 @default.
• W3010803776 hasConceptScore W3010803776C107130276 @default.
• W3010803776 hasConceptScore W3010803776C120665830 @default.
• W3010803776 hasConceptScore W3010803776C121332964 @default.
• W3010803776 hasConceptScore W3010803776C126322002 @default.
• W3010803776 hasConceptScore W3010803776C181199279 @default.
• W3010803776 hasConceptScore W3010803776C185592680 @default.
• W3010803776 hasConceptScore W3010803776C187212893 @default.
• W3010803776 hasConceptScore W3010803776C2776608514 @default.
• W3010803776 hasConceptScore W3010803776C2777608289 @default.
• W3010803776 hasConceptScore W3010803776C2777724520 @default.
• W3010803776 hasConceptScore W3010803776C2779201268 @default.
• W3010803776 hasConceptScore W3010803776C2781179581 @default.
• W3010803776 hasConceptScore W3010803776C55493867 @default.
• W3010803776 hasConceptScore W3010803776C61511704 @default.
• W3010803776 hasConceptScore W3010803776C71924100 @default.
• W3010803776 hasConceptScore W3010803776C72563966 @default.
• W3010803776 hasConceptScore W3010803776C77411442 @default.
• W3010803776 hasIssue "3" @default.
• W3010803776 hasLocation W30108037761 @default.
• W3010803776 hasOpenAccess W3010803776 @default.
• W3010803776 hasPrimaryLocation W30108037761 @default.
• W3010803776 hasRelatedWork W2060022074 @default.
• W3010803776 hasRelatedWork W2084290125 @default.
• W3010803776 hasRelatedWork W2129436066 @default.
• W3010803776 hasRelatedWork W2233945311 @default.
• W3010803776 hasRelatedWork W2350777139 @default.
• W3010803776 hasRelatedWork W2404671072 @default.
• W3010803776 hasRelatedWork W2412203536 @default.
• W3010803776 hasRelatedWork W2421330650 @default.
• W3010803776 hasRelatedWork W2614178882 @default.
• W3010803776 hasRelatedWork W59743238 @default.

• next