FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010805524> ?p ?o ?g. }

• W3010805524 abstract "Abstract Background This investigation was arranged to elucidate whether single nucleotide polymorphisms (SNPs) of lncRNA UCA1 was implicated in elevating colorectal cancer (CRC) risk by interacting with environmental exposures. Methods LncRNASNP database was firstly adopted to predict SNPs that possibly affected binding of UCA1 with miRNAs and then the interactive effect of SNPs and environmental exposure on CRC risk was evaluated by recurring to type 2 gene-environment interactions (GEI) model. Besides, MTT assay, colony formation assay, transwell assay and wound healing assay were performed to assess the activity of CRC cell lines which carried distinct genotypes of specific SNPs. The impact of nicotine on activity of CRC cells was also appraised. Results SNP rs12982687 of UCA1 intervened in the binding capacity of UCA1 with several miRNAs, especially miR-873-5p. MiRNAs regulated by UCA1, as predicted by mirPath software, shared genes that were enriched in HIF1 signaling pathway. Moreover, homozygote TT of rs12982687 reduced CRC risk among smokers, and CRC cells that carried rs12982687 (CC) displayed strong migration and invasion. By contrast, miR-873-5p mimic, which reduced UCA1 expression, delayed metastasis of CRC cells (all P < 0.05). Additionally, nicotine not merely elevated UCA1 and HIF-1α expressions in CRC cells, but also facilitated proliferation and metastasis of CRC cells ( P < 0.05). Conclusions SNP rs12982687 was involved in smoking-triggered CRC progression, given its influence on UCA1's binding with miR-873-5p and HIF-1 signaling." @default.
• W3010805524 created "2020-03-23" @default.
• W3010805524 creator A5021870687 @default.
• W3010805524 creator A5022063584 @default.
• W3010805524 creator A5023854164 @default.
• W3010805524 creator A5024739967 @default.
• W3010805524 creator A5026162805 @default.
• W3010805524 creator A5040042001 @default.
• W3010805524 creator A5050102830 @default.
• W3010805524 creator A5051894963 @default.
• W3010805524 creator A5059266056 @default.
• W3010805524 creator A5074951662 @default.
• W3010805524 creator A5077328236 @default.
• W3010805524 creator A5085028455 @default.
• W3010805524 date "2020-03-06" @default.
• W3010805524 modified "2023-10-11" @default.
• W3010805524 title "SNP rs12982687 affects binding capacity of lncRNA UCA1 with miR-873-5p: involvement in smoking-triggered colorectal cancer progression" @default.
• W3010805524 cites W1539551850 @default.
• W3010805524 cites W1856228646 @default.
• W3010805524 cites W1978445751 @default.
• W3010805524 cites W1978586737 @default.
• W3010805524 cites W1979906856 @default.
• W3010805524 cites W1993868761 @default.
• W3010805524 cites W1993926061 @default.
• W3010805524 cites W2006556963 @default.
• W3010805524 cites W2012020865 @default.
• W3010805524 cites W2023691360 @default.
• W3010805524 cites W2031034208 @default.
• W3010805524 cites W2035983112 @default.
• W3010805524 cites W2040530356 @default.
• W3010805524 cites W2047330407 @default.
• W3010805524 cites W2048447535 @default.
• W3010805524 cites W2049818912 @default.
• W3010805524 cites W2064591654 @default.
• W3010805524 cites W2078526959 @default.
• W3010805524 cites W2079168513 @default.
• W3010805524 cites W2094620176 @default.
• W3010805524 cites W2097540122 @default.
• W3010805524 cites W2100007292 @default.
• W3010805524 cites W2103683311 @default.
• W3010805524 cites W2109985652 @default.
• W3010805524 cites W2111688179 @default.
• W3010805524 cites W2112645200 @default.
• W3010805524 cites W2117902111 @default.
• W3010805524 cites W2120805410 @default.
• W3010805524 cites W2131878646 @default.
• W3010805524 cites W2133794263 @default.
• W3010805524 cites W2134722719 @default.
• W3010805524 cites W2137226828 @default.
• W3010805524 cites W2138412834 @default.
• W3010805524 cites W2141211932 @default.
• W3010805524 cites W2152041515 @default.
• W3010805524 cites W2162774299 @default.
• W3010805524 cites W2164595979 @default.
• W3010805524 cites W2172654775 @default.
• W3010805524 cites W2190647258 @default.
• W3010805524 cites W2270683385 @default.
• W3010805524 cites W2314431227 @default.
• W3010805524 cites W2362746702 @default.
• W3010805524 cites W2515771386 @default.
• W3010805524 cites W2520617849 @default.
• W3010805524 cites W2523048631 @default.
• W3010805524 cites W2532060477 @default.
• W3010805524 cites W2549823067 @default.
• W3010805524 cites W2566612401 @default.
• W3010805524 cites W2622909890 @default.
• W3010805524 cites W2744067450 @default.
• W3010805524 cites W2766837662 @default.
• W3010805524 cites W2778943166 @default.
• W3010805524 cites W2803936466 @default.
• W3010805524 cites W621464006 @default.
• W3010805524 doi "https://doi.org/10.1186/s12964-020-0518-0" @default.
• W3010805524 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7059387" @default.
• W3010805524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32143722" @default.
• W3010805524 hasPublicationYear "2020" @default.
• W3010805524 type Work @default.
• W3010805524 sameAs 3010805524 @default.
• W3010805524 citedByCount "23" @default.
• W3010805524 countsByYear W30108055242020 @default.
• W3010805524 countsByYear W30108055242021 @default.
• W3010805524 countsByYear W30108055242022 @default.
• W3010805524 countsByYear W30108055242023 @default.
• W3010805524 crossrefType "journal-article" @default.
• W3010805524 hasAuthorship W3010805524A5021870687 @default.
• W3010805524 hasAuthorship W3010805524A5022063584 @default.
• W3010805524 hasAuthorship W3010805524A5023854164 @default.
• W3010805524 hasAuthorship W3010805524A5024739967 @default.
• W3010805524 hasAuthorship W3010805524A5026162805 @default.
• W3010805524 hasAuthorship W3010805524A5040042001 @default.
• W3010805524 hasAuthorship W3010805524A5050102830 @default.
• W3010805524 hasAuthorship W3010805524A5051894963 @default.
• W3010805524 hasAuthorship W3010805524A5059266056 @default.
• W3010805524 hasAuthorship W3010805524A5074951662 @default.
• W3010805524 hasAuthorship W3010805524A5077328236 @default.
• W3010805524 hasAuthorship W3010805524A5085028455 @default.
• W3010805524 hasBestOaLocation W30108055241 @default.
• W3010805524 hasConcept C104317684 @default.
• W3010805524 hasConcept C121608353 @default.
• W3010805524 hasConcept C126322002 @default.
• W3010805524 hasConcept C135763542 @default.

• next