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- W3010807391 endingPage "137" @default.
- W3010807391 startingPage "109" @default.
- W3010807391 abstract "Phosphoinositide 3-kinase delta (PI3Kδ) mediates signaling transduction downstream of diverse immune receptors, including the T cell receptor (TCR), the B cell receptor (BCR), costimulatory molecules and cytokine receptors. Our understanding of the role of PI3Kδ in the immune system comes primarily from mice, and especially from the consequences of pharmacological inhibition of PI3Kδ in mouse models of human disease as well as the consequences of genetic manipulation, resulting in hyperactivation or loss of PI3Kδ function. In case of humans, in vitro studies with PI3Kδ-specific inhibitors, the consequences of treatment of hematologic malignancies with the PI3Kδ-specific inhibitor idelalisib and primary immunodeficiency disorders due to germline variants hyper- or underactivating PI3Kδ provide most of our knowledge on the role of PI3Kδ in immunity and immune regulation. In this review, we summarize the physiological and pathophysiological roles of PI3Kδ in the human immune system, focusing on immunodeficiency due to defects in PI3Kδ signaling and especially on the recently reported cases with mutations resulting in loss of PI3Kδ activity." @default.
- W3010807391 created "2020-03-23" @default.
- W3010807391 creator A5002081523 @default.
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- W3010807391 creator A5036911759 @default.
- W3010807391 creator A5059354119 @default.
- W3010807391 creator A5073818116 @default.
- W3010807391 date "2020-01-01" @default.
- W3010807391 modified "2023-10-14" @default.
- W3010807391 title "Homeostatic and pathogenic roles of PI3Kδ in the human immune system" @default.
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