FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010807461> ?p ?o ?g. }

• W3010807461 abstract "Abstract The CORL family of CNS-specific proteins share a Smad-binding region with mammalian SnoN and c-Ski protooncogenes. In this family Drosophila CORL has two mouse and two human relatives. Roles for the mouse and human CORL proteins are largely unknown. Based on genome-wide association studies linking the human CORL proteins Fussel15 and Fussel18 with ataxia, we tested the hypothesis that dCORL mutations will cause adult movement disorders. For our initial tests, we conducted side by side studies of adults with the small deletion Df(4)dCORL and eight control strains. We found that deletion mutants exhibit three types of behavioral plasticity. First, significant climbing defects attributable to loss of dCORL are eliminated by age. Second, significant phototaxis defects due to loss of dCORL are partially ameliorated by age and are not due to faulty photoreceptors. Third, Df(4)dCORL males raised in groups have a lower courtship index than males raised as singles though this defect is not due to loss of dCORL. Subsequent tests showed that the climbing and phototaxis defects were phenocpied by dCORL21B and dCORL23C two CRISPR generated mutations. Overall, the finding that adult movement defects due to loss of dCORL are subject to age-dependent plasticity suggests new hypotheses for CORL functions in flies and mammals." @default.
• W3010807461 created "2020-03-23" @default.
• W3010807461 creator A5013717935 @default.
• W3010807461 creator A5016286783 @default.
• W3010807461 creator A5016296853 @default.
• W3010807461 creator A5030891600 @default.
• W3010807461 creator A5034944049 @default.
• W3010807461 creator A5040567484 @default.
• W3010807461 creator A5056336149 @default.
• W3010807461 creator A5066608401 @default.
• W3010807461 date "2020-05-01" @default.
• W3010807461 modified "2023-10-15" @default.
• W3010807461 title "Adult Movement Defects Associated with a CORL Mutation in Drosophila Display Behavioral Plasticity" @default.
• W3010807461 cites W1990430985 @default.
• W3010807461 cites W1991543373 @default.
• W3010807461 cites W2029374683 @default.
• W3010807461 cites W2033300068 @default.
• W3010807461 cites W2040852624 @default.
• W3010807461 cites W2043959257 @default.
• W3010807461 cites W2057507618 @default.
• W3010807461 cites W2066129391 @default.
• W3010807461 cites W2092301439 @default.
• W3010807461 cites W2094140521 @default.
• W3010807461 cites W2132143717 @default.
• W3010807461 cites W2136982019 @default.
• W3010807461 cites W2143765921 @default.
• W3010807461 cites W2150488996 @default.
• W3010807461 cites W2151026694 @default.
• W3010807461 cites W2167898988 @default.
• W3010807461 cites W2565165152 @default.
• W3010807461 cites W2590819384 @default.
• W3010807461 cites W2803429809 @default.
• W3010807461 cites W2805642122 @default.
• W3010807461 cites W2807768758 @default.
• W3010807461 cites W2865374766 @default.
• W3010807461 cites W2884430704 @default.
• W3010807461 cites W2898204371 @default.
• W3010807461 cites W2914312676 @default.
• W3010807461 cites W2974495713 @default.
• W3010807461 cites W4235571478 @default.
• W3010807461 doi "https://doi.org/10.1534/g3.120.400648" @default.
• W3010807461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7202012" @default.
• W3010807461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32161085" @default.
• W3010807461 hasPublicationYear "2020" @default.
• W3010807461 type Work @default.
• W3010807461 sameAs 3010807461 @default.
• W3010807461 citedByCount "1" @default.
• W3010807461 countsByYear W30108074612022 @default.
• W3010807461 crossrefType "journal-article" @default.
• W3010807461 hasAuthorship W3010807461A5013717935 @default.
• W3010807461 hasAuthorship W3010807461A5016286783 @default.
• W3010807461 hasAuthorship W3010807461A5016296853 @default.
• W3010807461 hasAuthorship W3010807461A5030891600 @default.
• W3010807461 hasAuthorship W3010807461A5034944049 @default.
• W3010807461 hasAuthorship W3010807461A5040567484 @default.
• W3010807461 hasAuthorship W3010807461A5056336149 @default.
• W3010807461 hasAuthorship W3010807461A5066608401 @default.
• W3010807461 hasBestOaLocation W30108074611 @default.
• W3010807461 hasConcept C104317684 @default.
• W3010807461 hasConcept C143065580 @default.
• W3010807461 hasConcept C169760540 @default.
• W3010807461 hasConcept C18903297 @default.
• W3010807461 hasConcept C2776041557 @default.
• W3010807461 hasConcept C2776453541 @default.
• W3010807461 hasConcept C2780104201 @default.
• W3010807461 hasConcept C2780906641 @default.
• W3010807461 hasConcept C501734568 @default.
• W3010807461 hasConcept C54355233 @default.
• W3010807461 hasConcept C86803240 @default.
• W3010807461 hasConcept C90856448 @default.
• W3010807461 hasConcept C95038775 @default.
• W3010807461 hasConceptScore W3010807461C104317684 @default.
• W3010807461 hasConceptScore W3010807461C143065580 @default.
• W3010807461 hasConceptScore W3010807461C169760540 @default.
• W3010807461 hasConceptScore W3010807461C18903297 @default.
• W3010807461 hasConceptScore W3010807461C2776041557 @default.
• W3010807461 hasConceptScore W3010807461C2776453541 @default.
• W3010807461 hasConceptScore W3010807461C2780104201 @default.
• W3010807461 hasConceptScore W3010807461C2780906641 @default.
• W3010807461 hasConceptScore W3010807461C501734568 @default.
• W3010807461 hasConceptScore W3010807461C54355233 @default.
• W3010807461 hasConceptScore W3010807461C86803240 @default.
• W3010807461 hasConceptScore W3010807461C90856448 @default.
• W3010807461 hasConceptScore W3010807461C95038775 @default.
• W3010807461 hasLocation W30108074611 @default.
• W3010807461 hasLocation W30108074612 @default.
• W3010807461 hasLocation W30108074613 @default.
• W3010807461 hasLocation W30108074614 @default.
• W3010807461 hasLocation W30108074615 @default.
• W3010807461 hasOpenAccess W3010807461 @default.
• W3010807461 hasPrimaryLocation W30108074611 @default.
• W3010807461 hasRelatedWork W1969421403 @default.
• W3010807461 hasRelatedWork W1975475507 @default.
• W3010807461 hasRelatedWork W1981280547 @default.
• W3010807461 hasRelatedWork W2076675697 @default.
• W3010807461 hasRelatedWork W2085262393 @default.
• W3010807461 hasRelatedWork W2150079170 @default.
• W3010807461 hasRelatedWork W2234446029 @default.
• W3010807461 hasRelatedWork W2410041588 @default.
• W3010807461 hasRelatedWork W4241211511 @default.

• next