Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010808046> ?p ?o ?g. }
- W3010808046 endingPage "25" @default.
- W3010808046 startingPage "17" @default.
- W3010808046 abstract "Objectives: Hepatocellular carcinoma (HCC) is characterized by elevated in oxidative stress and inflammatory cytokines, which enhance destructive effects of the tumor. Therefore, we conducted this study to investigate the protective effects of sodium ascorbate against thioacetamide-induced HCC in rats through studying its effect on the apoptotic pathway in rats. In addition, in vitro activity of sodium ascorbate was investigated on HepG2 and compared with cisplatin.Methods: HCC was experimentally induced by injecting rats with 200 mg/kg thioacetamide intraperitoneally twice weekly for 16 weeks. Part of HCC rats was concomitantly treated with 100 mg/kg sodium ascorbate intraperitoneally during the 16-week period. Hepatic tissues were used for the determination of NFκB, Nrf2, TNF-α, caspase-3, caspase-8 and caspase-9.Results: Sodium ascorbate significantly attenuated HCC-induced reduction in the expression of NrF2 associated with a reduction in concentrations of hydrogen peroxide and superoxide anion. In addition, sodium ascorbate blocked HCC-induced increase in the expression of NFκB and TNF-α. Sodium ascorbate slightly increased the activity of caspase-3, -8 and -9 in vitro but inhibited their activities in vivo.Conclusion: In spite of the antioxidant and anti-inflammatory activity of sodium ascorbate, it produced selective cytotoxic activity via direct activation of the apoptotic pathway in cancer cells without affecting the apoptotic pathway in normal hepatic cells." @default.
- W3010808046 created "2020-03-23" @default.
- W3010808046 creator A5001277821 @default.
- W3010808046 creator A5006079326 @default.
- W3010808046 creator A5024701982 @default.
- W3010808046 creator A5028080816 @default.
- W3010808046 creator A5052495689 @default.
- W3010808046 creator A5068323935 @default.
- W3010808046 creator A5068976257 @default.
- W3010808046 creator A5091680239 @default.
- W3010808046 date "2020-01-01" @default.
- W3010808046 modified "2023-10-16" @default.
- W3010808046 title "Selective cytotoxic activity and protective effects of sodium ascorbate against hepatocellular carcinoma through its effect on oxidative stress and apoptosis <i>in vivo</i> and <i>in vitro</i>" @default.
- W3010808046 cites W1574542346 @default.
- W3010808046 cites W1587498818 @default.
- W3010808046 cites W1785455093 @default.
- W3010808046 cites W1912082470 @default.
- W3010808046 cites W1942321192 @default.
- W3010808046 cites W1965824583 @default.
- W3010808046 cites W1967376496 @default.
- W3010808046 cites W1971189741 @default.
- W3010808046 cites W1975555032 @default.
- W3010808046 cites W1991070017 @default.
- W3010808046 cites W1996703005 @default.
- W3010808046 cites W2022181788 @default.
- W3010808046 cites W2034447209 @default.
- W3010808046 cites W2035787997 @default.
- W3010808046 cites W2045281985 @default.
- W3010808046 cites W2045886520 @default.
- W3010808046 cites W2047179372 @default.
- W3010808046 cites W2047470479 @default.
- W3010808046 cites W2078608235 @default.
- W3010808046 cites W2092555653 @default.
- W3010808046 cites W2101861123 @default.
- W3010808046 cites W2135702330 @default.
- W3010808046 cites W2136239966 @default.
- W3010808046 cites W2140968862 @default.
- W3010808046 cites W2146679006 @default.
- W3010808046 cites W2147164761 @default.
- W3010808046 cites W2148253377 @default.
- W3010808046 cites W2149726328 @default.
- W3010808046 cites W2157653515 @default.
- W3010808046 cites W2160740567 @default.
- W3010808046 cites W2165134425 @default.
- W3010808046 cites W2165638318 @default.
- W3010808046 cites W2169598496 @default.
- W3010808046 cites W2181302091 @default.
- W3010808046 cites W227029814 @default.
- W3010808046 cites W2314935329 @default.
- W3010808046 cites W2325106907 @default.
- W3010808046 cites W2409065198 @default.
- W3010808046 cites W2517026509 @default.
- W3010808046 cites W2770432229 @default.
- W3010808046 cites W2792325497 @default.
- W3010808046 cites W2802387243 @default.
- W3010808046 cites W2918149478 @default.
- W3010808046 cites W2966428358 @default.
- W3010808046 cites W4256206092 @default.
- W3010808046 cites W87350884 @default.
- W3010808046 doi "https://doi.org/10.1080/13510002.2020.1739870" @default.
- W3010808046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7144217" @default.
- W3010808046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32172678" @default.
- W3010808046 hasPublicationYear "2020" @default.
- W3010808046 type Work @default.
- W3010808046 sameAs 3010808046 @default.
- W3010808046 citedByCount "7" @default.
- W3010808046 countsByYear W30108080462021 @default.
- W3010808046 countsByYear W30108080462022 @default.
- W3010808046 countsByYear W30108080462023 @default.
- W3010808046 crossrefType "journal-article" @default.
- W3010808046 hasAuthorship W3010808046A5001277821 @default.
- W3010808046 hasAuthorship W3010808046A5006079326 @default.
- W3010808046 hasAuthorship W3010808046A5024701982 @default.
- W3010808046 hasAuthorship W3010808046A5028080816 @default.
- W3010808046 hasAuthorship W3010808046A5052495689 @default.
- W3010808046 hasAuthorship W3010808046A5068323935 @default.
- W3010808046 hasAuthorship W3010808046A5068976257 @default.
- W3010808046 hasAuthorship W3010808046A5091680239 @default.
- W3010808046 hasBestOaLocation W30108080461 @default.
- W3010808046 hasConcept C12519072 @default.
- W3010808046 hasConcept C150903083 @default.
- W3010808046 hasConcept C178790620 @default.
- W3010808046 hasConcept C185592680 @default.
- W3010808046 hasConcept C190283241 @default.
- W3010808046 hasConcept C202751555 @default.
- W3010808046 hasConcept C207001950 @default.
- W3010808046 hasConcept C2775838275 @default.
- W3010808046 hasConcept C2776151105 @default.
- W3010808046 hasConcept C2778004101 @default.
- W3010808046 hasConcept C2780247646 @default.
- W3010808046 hasConcept C2781057625 @default.
- W3010808046 hasConcept C2986274086 @default.
- W3010808046 hasConcept C31573885 @default.
- W3010808046 hasConcept C31903555 @default.
- W3010808046 hasConcept C537181965 @default.
- W3010808046 hasConcept C55493867 @default.
- W3010808046 hasConcept C71924100 @default.
- W3010808046 hasConcept C86803240 @default.