FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010808413> ?p ?o ?g. }

• W3010808413 abstract "Despite the success of immunotherapy using checkpoint blockade, many patients with solid tumors remain refractory to these treatments. In human cancer, the experimental options to investigate the specific effects of antibodies blocking inhibitory receptors are limited and it is still unclear which cell types are involved. We addressed the question whether the direct interaction between T cells and tumor cells can be enforced through blocking a set of inhibitory receptors including PD-1, TIM-3, BTLA and LAG-3, blocked either individually or in dual combinations with the anti-PD-1 antibody, and to determine the condition that induces maximal T cell function preventing tumor cell proliferation. Using short-term Melan-A-specific or autologous re-stimulations, checkpoint blockade did not consistently increase cytokine production by tumor-derived expanded T cells. We next set up a 5-day co-culture assay with autologous melanoma cell lines and expanded tumor infiltrating T cells, originating from tumor specimens obtained from 6 different patients. Amongst all combos tested, we observed that blockade of LAG-3 alone, and more strongly when combined with PD-1 blockade, enforced T cell responses and tumor cell growth control. The combination of anti-LAG-3 plus anti-PD-1 acted through CD8 T cells and led to increased IFNγ production and cytotoxic capacity. Our results show that LAG-3 and PD-1 are regulating the direct interaction between tumor cells and autologous T cells, suggesting that therapy effects may be promoted by enhanced access of the corresponding blocking reagents to the tumor microenvironment." @default.
• W3010808413 created "2020-03-23" @default.
• W3010808413 creator A5024641105 @default.
• W3010808413 creator A5027433697 @default.
• W3010808413 creator A5036824713 @default.
• W3010808413 creator A5040470656 @default.
• W3010808413 creator A5054083233 @default.
• W3010808413 creator A5062630970 @default.
• W3010808413 creator A5078417104 @default.
• W3010808413 creator A5079146691 @default.
• W3010808413 creator A5079384669 @default.
• W3010808413 date "2020-01-01" @default.
• W3010808413 modified "2023-10-17" @default.
• W3010808413 title "LAG-3 and PD-1+LAG-3 inhibition promote anti-tumor immune responses in human autologous melanoma/T cell co-cultures" @default.
• W3010808413 cites W1536612607 @default.
• W3010808413 cites W1910384556 @default.
• W3010808413 cites W1971208896 @default.
• W3010808413 cites W1981291019 @default.
• W3010808413 cites W2021165507 @default.
• W3010808413 cites W2022216088 @default.
• W3010808413 cites W2039123767 @default.
• W3010808413 cites W2041143310 @default.
• W3010808413 cites W2048073154 @default.
• W3010808413 cites W2066671159 @default.
• W3010808413 cites W2088265818 @default.
• W3010808413 cites W2098020683 @default.
• W3010808413 cites W2101653483 @default.
• W3010808413 cites W2103950437 @default.
• W3010808413 cites W2107598346 @default.
• W3010808413 cites W2114238926 @default.
• W3010808413 cites W2119064369 @default.
• W3010808413 cites W2122730216 @default.
• W3010808413 cites W2124427232 @default.
• W3010808413 cites W2133075384 @default.
• W3010808413 cites W2139591061 @default.
• W3010808413 cites W2140053672 @default.
• W3010808413 cites W2147605136 @default.
• W3010808413 cites W2149121521 @default.
• W3010808413 cites W2159124392 @default.
• W3010808413 cites W2160834915 @default.
• W3010808413 cites W2301707196 @default.
• W3010808413 cites W2406612864 @default.
• W3010808413 cites W2507334943 @default.
• W3010808413 cites W2592935721 @default.
• W3010808413 cites W2596760231 @default.
• W3010808413 cites W2742763599 @default.
• W3010808413 cites W2782007611 @default.
• W3010808413 cites W2791483720 @default.
• W3010808413 cites W2794137041 @default.
• W3010808413 cites W2796643083 @default.
• W3010808413 cites W2889169377 @default.
• W3010808413 cites W2902968854 @default.
• W3010808413 cites W2951153979 @default.
• W3010808413 doi "https://doi.org/10.1080/2162402x.2020.1736792" @default.
• W3010808413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7422827" @default.
• W3010808413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32850194" @default.
• W3010808413 hasPublicationYear "2020" @default.
• W3010808413 type Work @default.
• W3010808413 sameAs 3010808413 @default.
• W3010808413 citedByCount "29" @default.
• W3010808413 countsByYear W30108084132020 @default.
• W3010808413 countsByYear W30108084132021 @default.
• W3010808413 countsByYear W30108084132022 @default.
• W3010808413 countsByYear W30108084132023 @default.
• W3010808413 crossrefType "journal-article" @default.
• W3010808413 hasAuthorship W3010808413A5024641105 @default.
• W3010808413 hasAuthorship W3010808413A5027433697 @default.
• W3010808413 hasAuthorship W3010808413A5036824713 @default.
• W3010808413 hasAuthorship W3010808413A5040470656 @default.
• W3010808413 hasAuthorship W3010808413A5054083233 @default.
• W3010808413 hasAuthorship W3010808413A5062630970 @default.
• W3010808413 hasAuthorship W3010808413A5078417104 @default.
• W3010808413 hasAuthorship W3010808413A5079146691 @default.
• W3010808413 hasAuthorship W3010808413A5079384669 @default.
• W3010808413 hasBestOaLocation W30108084131 @default.
• W3010808413 hasConcept C126322002 @default.
• W3010808413 hasConcept C154317977 @default.
• W3010808413 hasConcept C159654299 @default.
• W3010808413 hasConcept C167672396 @default.
• W3010808413 hasConcept C170493617 @default.
• W3010808413 hasConcept C202751555 @default.
• W3010808413 hasConcept C203014093 @default.
• W3010808413 hasConcept C2776090121 @default.
• W3010808413 hasConcept C2776107976 @default.
• W3010808413 hasConcept C2777658100 @default.
• W3010808413 hasConcept C2777701055 @default.
• W3010808413 hasConcept C2778468042 @default.
• W3010808413 hasConcept C2778690821 @default.
• W3010808413 hasConcept C2780674031 @default.
• W3010808413 hasConcept C2780851360 @default.
• W3010808413 hasConcept C45121317 @default.
• W3010808413 hasConcept C502942594 @default.
• W3010808413 hasConcept C55493867 @default.
• W3010808413 hasConcept C71924100 @default.
• W3010808413 hasConcept C86803240 @default.
• W3010808413 hasConcept C8891405 @default.
• W3010808413 hasConceptScore W3010808413C126322002 @default.
• W3010808413 hasConceptScore W3010808413C154317977 @default.
• W3010808413 hasConceptScore W3010808413C159654299 @default.
• W3010808413 hasConceptScore W3010808413C167672396 @default.

• next