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- W3010809239 abstract "Stress promotes negative affective states, which include anhedonia and passive coping. While these features are in part mediated by neuroadaptations in brain reward circuitry, a comprehensive framework of how stress-induced negative affect may be encoded within key nodes of this circuit is lacking. Here, we show in a mouse model for stress-induced anhedonia and passive coping that these phenomena are associated with increased synaptic strength of ventral hippocampus (VH) excitatory synapses onto D1 medium spiny neurons (D1-MSNs) in the nucleus accumbens medial shell (NAcmSh), and with lateral hypothalamus (LH)-projecting D1-MSN hyperexcitability mediated by decreased inwardly rectifying potassium channel (IRK) function. Stress-induced negative affective states are prevented by depotentiation of VH to NAcmSh synapses, restoring Kir2.1 function in D1R-MSNs, or disrupting co-participation of these synaptic and intrinsic adaptations in D1-MSNs. In conclusion, our data provide strong evidence for a disynaptic pathway controlling maladaptive emotional behavior." @default.
- W3010809239 created "2020-03-23" @default.
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- W3010809239 date "2020-03-11" @default.
- W3010809239 modified "2023-10-15" @default.
- W3010809239 title "Cooperative synaptic and intrinsic plasticity in a disynaptic limbic circuit drive stress-induced anhedonia and passive coping in mice" @default.
- W3010809239 cites W1499988969 @default.
- W3010809239 cites W1511397211 @default.
- W3010809239 cites W1511786579 @default.
- W3010809239 cites W1875506666 @default.
- W3010809239 cites W1906859819 @default.
- W3010809239 cites W1927429241 @default.
- W3010809239 cites W1964175549 @default.
- W3010809239 cites W1965110331 @default.
- W3010809239 cites W1978891587 @default.
- W3010809239 cites W1981654563 @default.
- W3010809239 cites W1986469863 @default.
- W3010809239 cites W1991603311 @default.
- W3010809239 cites W1993897510 @default.
- W3010809239 cites W2003448057 @default.
- W3010809239 cites W2004873925 @default.
- W3010809239 cites W2005027616 @default.
- W3010809239 cites W2019901441 @default.
- W3010809239 cites W2022082745 @default.
- W3010809239 cites W2023595618 @default.
- W3010809239 cites W2036779245 @default.
- W3010809239 cites W2051005796 @default.
- W3010809239 cites W2052390712 @default.
- W3010809239 cites W2053472601 @default.
- W3010809239 cites W2058073897 @default.
- W3010809239 cites W2061444930 @default.
- W3010809239 cites W2071815275 @default.
- W3010809239 cites W2073595900 @default.
- W3010809239 cites W2077208091 @default.
- W3010809239 cites W2077523950 @default.
- W3010809239 cites W2085155996 @default.
- W3010809239 cites W2103704610 @default.
- W3010809239 cites W2104135721 @default.
- W3010809239 cites W2109434471 @default.
- W3010809239 cites W2110925924 @default.
- W3010809239 cites W2127114472 @default.
- W3010809239 cites W2136552664 @default.
- W3010809239 cites W2139358036 @default.
- W3010809239 cites W2141609201 @default.
- W3010809239 cites W2144205676 @default.
- W3010809239 cites W2146054031 @default.
- W3010809239 cites W2149904207 @default.
- W3010809239 cites W2155686640 @default.
- W3010809239 cites W2157504436 @default.
- W3010809239 cites W2159202946 @default.
- W3010809239 cites W2161321963 @default.
- W3010809239 cites W2162227712 @default.
- W3010809239 cites W2165692873 @default.
- W3010809239 cites W2178079081 @default.
- W3010809239 cites W2234540276 @default.
- W3010809239 cites W2248682259 @default.
- W3010809239 cites W2254670992 @default.
- W3010809239 cites W2257819777 @default.
- W3010809239 cites W2264430018 @default.
- W3010809239 cites W2266819934 @default.
- W3010809239 cites W2318635905 @default.
- W3010809239 cites W2408529313 @default.
- W3010809239 cites W2520064463 @default.
- W3010809239 cites W2525578234 @default.
- W3010809239 cites W2570245225 @default.
- W3010809239 cites W2573028465 @default.
- W3010809239 cites W2620619632 @default.
- W3010809239 cites W2724120353 @default.
- W3010809239 cites W2760617544 @default.
- W3010809239 cites W2762868429 @default.
- W3010809239 cites W2782249154 @default.
- W3010809239 cites W2785770559 @default.
- W3010809239 cites W2787343838 @default.
- W3010809239 cites W2787419526 @default.
- W3010809239 cites W2793357593 @default.
- W3010809239 cites W2794251999 @default.
- W3010809239 cites W2796699806 @default.
- W3010809239 cites W2800294157 @default.
- W3010809239 cites W2811270075 @default.
- W3010809239 cites W2888510300 @default.
- W3010809239 cites W2899048073 @default.