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- W3010809611 endingPage "2490" @default.
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- W3010809611 abstract "Abstract Conventional T cells recognise protein‐derived antigens in the context of major histocompatibility complex (MHC) class Ia and class II molecules and provide anti‐microbial and anti‐tumour immunity. Conventional T cells have also been implicated in type IV (also termed delayed‐type or T cell–mediated) hypersensitivity reactions in response to protein‐derived allergen antigens. In addition to conventional T cells, subsets of unconventional T cells exist, which recognise non‐protein antigens in the context of monomorphic MHC class I‐like molecules. These include T cells that are restricted to the cluster of differentiation 1 (CD1) family members, known as CD1‐restricted T cells, and mucosal‐associated invariant T cells (MAIT cells) that are restricted to the MHC‐related protein 1 (MR1). Compared with conventional T cells, much less is known about the immune functions of unconventional T cells and their role in hypersensitivities. Here, we review allergen antigen presentation by MHC‐I‐like molecules, their recognition by unconventional T cells, and the potential role of unconventional T cells in hypersensitivities. We also speculate on possible scenarios of allergen antigen presentation by MHC‐I‐like molecules to unconventional T cells, the hallmarks of such responses, and the expected frequencies of hypersensitivities within the human population." @default.
- W3010809611 created "2020-03-23" @default.
- W3010809611 creator A5021526585 @default.
- W3010809611 creator A5023421955 @default.
- W3010809611 creator A5059801276 @default.
- W3010809611 creator A5060750429 @default.
- W3010809611 creator A5064429934 @default.
- W3010809611 creator A5072166719 @default.
- W3010809611 creator A5076683873 @default.
- W3010809611 date "2020-04-13" @default.
- W3010809611 modified "2023-10-05" @default.
- W3010809611 title "Hypersensitivities following allergen antigen recognition by unconventional T cells" @default.
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