Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010809981> ?p ?o ?g. }
- W3010809981 endingPage "102504" @default.
- W3010809981 startingPage "102504" @default.
- W3010809981 abstract "Major depressive disorder (MDD) is a common condition that afflicts the general population across a broad spectrum of ages and social backgrounds. MDD has been identified by the World Health Organization as a leading cause of disability worldwide. Approximately 30% of patients are poor responsive to standard of care (SOC) treatment and novel therapeutic approaches are warranted. Since chronic inflammation, as it is often observed in certain cancers, type 2 diabetes, psoriasis and chronic arthritis, are accompanied by depression, it has been suggested that immunoinflammatory processes may be involved in the pathogenesis of MDD. Cytokines are a group of glycoproteins secreted from lymphoid and non-lymphoid cells that orchestrate immune responses. It has been suggested that a dysregulated production of cytokines may be implicated in the pathogenesis and maintenance of MDD. On the basis of their functions, cytokines can be subdivided in pro-inflammatory and anti-inflammatory cytokines. Since abnormal blood and cerebrospinal fluid of both pro and anti-inflammatory cytokines are altered in MDD, it has been suggested that abnormal cytokine homeostasis may be implicated in the pathogenesis of MDD and possibly to induction of therapeutic resistance. We review current data that indicate that cytokines may represent a useful tool to identify MDD patients that may benefit from tailored immunotherapeutic approaches and may represent a potential tailored therapeutic target." @default.
- W3010809981 created "2020-03-23" @default.
- W3010809981 creator A5018957190 @default.
- W3010809981 creator A5023483924 @default.
- W3010809981 creator A5028577533 @default.
- W3010809981 creator A5034146784 @default.
- W3010809981 creator A5039060959 @default.
- W3010809981 creator A5040381615 @default.
- W3010809981 creator A5042369638 @default.
- W3010809981 creator A5053483999 @default.
- W3010809981 creator A5084273559 @default.
- W3010809981 date "2020-05-01" @default.
- W3010809981 modified "2023-10-16" @default.
- W3010809981 title "The cytokine network in the pathogenesis of major depressive disorder. Close to translation?" @default.
- W3010809981 cites W1487955716 @default.
- W3010809981 cites W1488772574 @default.
- W3010809981 cites W1527011538 @default.
- W3010809981 cites W1542136448 @default.
- W3010809981 cites W1547937746 @default.
- W3010809981 cites W1568207206 @default.
- W3010809981 cites W1702526289 @default.
- W3010809981 cites W1871950814 @default.
- W3010809981 cites W1915473368 @default.
- W3010809981 cites W1937148812 @default.
- W3010809981 cites W1956693915 @default.
- W3010809981 cites W1965513983 @default.
- W3010809981 cites W1966761389 @default.
- W3010809981 cites W1969539443 @default.
- W3010809981 cites W1973929801 @default.
- W3010809981 cites W1981905302 @default.
- W3010809981 cites W1983045668 @default.
- W3010809981 cites W1985005182 @default.
- W3010809981 cites W1985100276 @default.
- W3010809981 cites W1987059521 @default.
- W3010809981 cites W1988563263 @default.
- W3010809981 cites W1988788559 @default.
- W3010809981 cites W1989029694 @default.
- W3010809981 cites W1989580462 @default.
- W3010809981 cites W1992868687 @default.
- W3010809981 cites W1994291342 @default.
- W3010809981 cites W1995586220 @default.
- W3010809981 cites W1996386643 @default.
- W3010809981 cites W1998411100 @default.
- W3010809981 cites W1998520631 @default.
- W3010809981 cites W2002267508 @default.
- W3010809981 cites W2002937734 @default.
- W3010809981 cites W2004243143 @default.
- W3010809981 cites W2005886168 @default.
- W3010809981 cites W2013887960 @default.
- W3010809981 cites W2018764785 @default.
- W3010809981 cites W2019640842 @default.
- W3010809981 cites W2021691186 @default.
- W3010809981 cites W2021779583 @default.
- W3010809981 cites W2024374510 @default.
- W3010809981 cites W2024951540 @default.
- W3010809981 cites W2026821172 @default.
- W3010809981 cites W2028763115 @default.
- W3010809981 cites W2029755823 @default.
- W3010809981 cites W2030593831 @default.
- W3010809981 cites W2036852936 @default.
- W3010809981 cites W2041352084 @default.
- W3010809981 cites W2044390612 @default.
- W3010809981 cites W2044803922 @default.
- W3010809981 cites W2045136785 @default.
- W3010809981 cites W2045281478 @default.
- W3010809981 cites W2045493616 @default.
- W3010809981 cites W2047981655 @default.
- W3010809981 cites W2048651807 @default.
- W3010809981 cites W2051212088 @default.
- W3010809981 cites W2051920122 @default.
- W3010809981 cites W2052259692 @default.
- W3010809981 cites W2052445727 @default.
- W3010809981 cites W2054093295 @default.
- W3010809981 cites W2054728160 @default.
- W3010809981 cites W2054927298 @default.
- W3010809981 cites W2055712213 @default.
- W3010809981 cites W2061536864 @default.
- W3010809981 cites W2065330512 @default.
- W3010809981 cites W2066503688 @default.
- W3010809981 cites W2073442404 @default.
- W3010809981 cites W2076072723 @default.
- W3010809981 cites W2084691692 @default.
- W3010809981 cites W2085628595 @default.
- W3010809981 cites W2086208662 @default.
- W3010809981 cites W2091259554 @default.
- W3010809981 cites W2093759195 @default.
- W3010809981 cites W2094329991 @default.
- W3010809981 cites W2094913456 @default.
- W3010809981 cites W2096856326 @default.
- W3010809981 cites W2101336705 @default.
- W3010809981 cites W2104205224 @default.
- W3010809981 cites W2107340757 @default.
- W3010809981 cites W2110969697 @default.
- W3010809981 cites W2116891319 @default.
- W3010809981 cites W2117395711 @default.
- W3010809981 cites W2120276500 @default.
- W3010809981 cites W2120386959 @default.
- W3010809981 cites W2122246785 @default.