FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010843852> ?p ?o ?g. }

• W3010843852 endingPage "146780" @default.
• W3010843852 startingPage "146780" @default.
• W3010843852 abstract "The prevention and treatment of sepsis associated encephalopathy (SAE) remains challenging in clinic. Besides the anti-infection treatments and goal-directed supportive treatments, no specific method is reported for the prevention and treatment of SAE. This study tried to investigate the effects and underlying mechanisms of small dose of L-dopa/Benserazide hydrochloride (L-DA) on SAE. We found that L-DA administration (i.p.) at early stage of sepsis, but not at late stage, improved learning and memory of sepsis surviving mice in Cecal ligation and perforation (CLP) model. Corresponding to the improvement of learning and memory in CLP model, L-DA administration limited neuroinflammation, improved neuroplasticity, reversed sepsis-induced decrease of hippocampal dopamine level, but had no obvious effects on the survival and body weight recovery. Further studies showed that specific inhibitors of dopamine D1 or D2 receptors both partly reduced the protective effect of L-DA on the learning and memory of lipopolysaccharides (LPS) treated mice. D1 receptor specific inhibitor significantly blocked the anti-neuroinflammation effects of L-DA in LPS treated mice, but D2 receptor inhibitor did not. All these suggest that L-DA administration could prevent and treat SAE via dopamine D1 and D2 receptors. Dopamine D1 receptor is a potential target of anti-neuroinflammation." @default.
• W3010843852 created "2020-03-23" @default.
• W3010843852 creator A5004145725 @default.
• W3010843852 creator A5005031664 @default.
• W3010843852 creator A5011808309 @default.
• W3010843852 creator A5034579880 @default.
• W3010843852 creator A5046881277 @default.
• W3010843852 creator A5050087493 @default.
• W3010843852 creator A5059190685 @default.
• W3010843852 creator A5068725975 @default.
• W3010843852 creator A5069563441 @default.
• W3010843852 creator A5070630819 @default.
• W3010843852 creator A5078253447 @default.
• W3010843852 creator A5081783937 @default.
• W3010843852 date "2020-06-01" @default.
• W3010843852 modified "2023-10-14" @default.
• W3010843852 title "Small dose of L-dopa/Benserazide hydrochloride improved sepsis-induced neuroinflammation and long-term cognitive dysfunction in sepsis mice" @default.
• W3010843852 cites W1552820890 @default.
• W3010843852 cites W1579609692 @default.
• W3010843852 cites W1797829451 @default.
• W3010843852 cites W1858871521 @default.
• W3010843852 cites W1970084030 @default.
• W3010843852 cites W1970943114 @default.
• W3010843852 cites W1974026398 @default.
• W3010843852 cites W1986926561 @default.
• W3010843852 cites W1989063324 @default.
• W3010843852 cites W2004773559 @default.
• W3010843852 cites W2006557195 @default.
• W3010843852 cites W2006754174 @default.
• W3010843852 cites W2035382111 @default.
• W3010843852 cites W2076143217 @default.
• W3010843852 cites W2080918867 @default.
• W3010843852 cites W2084158898 @default.
• W3010843852 cites W2091180729 @default.
• W3010843852 cites W2098572294 @default.
• W3010843852 cites W2115857282 @default.
• W3010843852 cites W2122113931 @default.
• W3010843852 cites W2122312517 @default.
• W3010843852 cites W2133829654 @default.
• W3010843852 cites W2146763135 @default.
• W3010843852 cites W2154513827 @default.
• W3010843852 cites W2179107628 @default.
• W3010843852 cites W2223946157 @default.
• W3010843852 cites W2266546441 @default.
• W3010843852 cites W2296607751 @default.
• W3010843852 cites W2317168190 @default.
• W3010843852 cites W2462234872 @default.
• W3010843852 cites W2531710602 @default.
• W3010843852 cites W2587752206 @default.
• W3010843852 cites W2600496322 @default.
• W3010843852 cites W2748434315 @default.
• W3010843852 cites W2769803536 @default.
• W3010843852 cites W2774694784 @default.
• W3010843852 cites W2802501803 @default.
• W3010843852 cites W2891617662 @default.
• W3010843852 cites W2908951486 @default.
• W3010843852 cites W2994905226 @default.
• W3010843852 cites W4211123396 @default.
• W3010843852 doi "https://doi.org/10.1016/j.brainres.2020.146780" @default.
• W3010843852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32205148" @default.
• W3010843852 hasPublicationYear "2020" @default.
• W3010843852 type Work @default.
• W3010843852 sameAs 3010843852 @default.
• W3010843852 citedByCount "12" @default.
• W3010843852 countsByYear W30108438522020 @default.
• W3010843852 countsByYear W30108438522022 @default.
• W3010843852 countsByYear W30108438522023 @default.
• W3010843852 crossrefType "journal-article" @default.
• W3010843852 hasAuthorship W3010843852A5004145725 @default.
• W3010843852 hasAuthorship W3010843852A5005031664 @default.
• W3010843852 hasAuthorship W3010843852A5011808309 @default.
• W3010843852 hasAuthorship W3010843852A5034579880 @default.
• W3010843852 hasAuthorship W3010843852A5046881277 @default.
• W3010843852 hasAuthorship W3010843852A5050087493 @default.
• W3010843852 hasAuthorship W3010843852A5059190685 @default.
• W3010843852 hasAuthorship W3010843852A5068725975 @default.
• W3010843852 hasAuthorship W3010843852A5069563441 @default.
• W3010843852 hasAuthorship W3010843852A5070630819 @default.
• W3010843852 hasAuthorship W3010843852A5078253447 @default.
• W3010843852 hasAuthorship W3010843852A5081783937 @default.
• W3010843852 hasConcept C126322002 @default.
• W3010843852 hasConcept C2776914184 @default.
• W3010843852 hasConcept C2778384902 @default.
• W3010843852 hasConcept C2779026782 @default.
• W3010843852 hasConcept C2779134260 @default.
• W3010843852 hasConcept C2779734285 @default.
• W3010843852 hasConcept C2780304432 @default.
• W3010843852 hasConcept C513476851 @default.
• W3010843852 hasConcept C71924100 @default.
• W3010843852 hasConcept C87753298 @default.
• W3010843852 hasConcept C98274493 @default.
• W3010843852 hasConceptScore W3010843852C126322002 @default.
• W3010843852 hasConceptScore W3010843852C2776914184 @default.
• W3010843852 hasConceptScore W3010843852C2778384902 @default.
• W3010843852 hasConceptScore W3010843852C2779026782 @default.
• W3010843852 hasConceptScore W3010843852C2779134260 @default.
• W3010843852 hasConceptScore W3010843852C2779734285 @default.
• W3010843852 hasConceptScore W3010843852C2780304432 @default.

• next