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• W3010846613 abstract "ABSTRACT The modulation of mechanical tension is important for sculpturing tissues during animal development, yet how mechanical tension is controlled remains poorly understood. In Drosophila wing discs, the local reduction of mechanical tension at basal cell edges results in basal relaxation and the formation of an epithelial fold. Here, we show that Wingless, which is expressed next to this fold, promotes basal cell edge tension to suppress the formation of this fold. Ectopic expression of Wingless blocks fold formation, whereas the depletion of Wingless increases fold depth. Moreover, local depletion of Wingless in a region where Wingless signal transduction is normally high results in ectopic fold formation. The depletion of Wingless also results in decreased basal cell edge tension and basal cell area relaxation. Conversely, the activation of Wingless signal transduction leads to increased basal cell edge tension and basal cell area constriction. Our results identify the Wingless signal transduction pathway as a crucial modulator of mechanical tension that is important for proper wing disc morphogenesis." @default.
• W3010846613 created "2020-03-23" @default.
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• W3010846613 date "2020-03-01" @default.
• W3010846613 modified "2023-10-14" @default.
• W3010846613 title "Wingless counteracts epithelial folding by increasing mechanical tension at basal cell edges in <i>Drosophila</i>" @default.
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• W3010846613 doi "https://doi.org/10.1242/dev.184713" @default.
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