FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010852673> ?p ?o ?g. }

• W3010852673 endingPage "1101" @default.
• W3010852673 startingPage "1094" @default.
• W3010852673 abstract "BackgroundDeep brain stimulation (DBS) of subcallosal cingulate cortex (SCC) is a promising investigational therapy for treatment-resistant depression (TRD). However, outcomes vary, likely due to suboptimal DBS placement. Ideal placement is proposed to stimulate 4 SCC white matter bundles; however, no quantitative data have linked activation of these target tracts to response.ObjectiveHere we used the volume of tissue activated (VTA) and probabilistic diffusion tensor imaging (DTI) to quantify tract activation relating to response.MethodsDTI was performed in 19 TRD patients who received SCC-DBS. We defined clinical response as >48% reduction from baseline in the Hamilton Depression Rating Scale. Bilateral VTAs were generated based on subject-specific stimulation parameters. Patient-specific tract maps emanating from the VTAs were calculated using whole-brain probabilistic DTI. The four target tracts were isolated using tract-specific quantification and examined for overlap with DBS activated tissue.ResultsMedial frontal and temporal projections were stimulated in all responders at 6 and 12 months. Individual tract-based generalized linear mixed model analysis revealed a significant tract-by-response interaction at both 6 (F(1,135) = 3.828, p = 0.001) and 12 (F(1,135) = 5.688, p < 0.001) months, with post hoc tests revealing a response-related increase in cingulum activation at 6 months (t(135) = 2.418, p = 0.017) and decrease in forceps minor activation at 12 months (t(135) = -2.802, p = 0.006).ConclusionsA wider profile of white matter tracts, particularly to the medial frontal, was associated with DBS response. Cingulum bundle stimulation may promote early response and excess stimulation of the forceps minor might be detrimental. Our work supports prospective patient-specific targeting to inform personalized DBS." @default.
• W3010852673 created "2020-03-23" @default.
• W3010852673 creator A5005367845 @default.
• W3010852673 creator A5034742107 @default.
• W3010852673 creator A5043095653 @default.
• W3010852673 creator A5047922852 @default.
• W3010852673 creator A5055960648 @default.
• W3010852673 creator A5056904269 @default.
• W3010852673 creator A5063029101 @default.
• W3010852673 date "2020-07-01" @default.
• W3010852673 modified "2023-09-26" @default.
• W3010852673 title "Tract-based analysis of target engagement by subcallosal cingulate deep brain stimulation for treatment resistant depression" @default.
• W3010852673 cites W1761785605 @default.
• W3010852673 cites W1869776851 @default.
• W3010852673 cites W1939848850 @default.
• W3010852673 cites W1964261330 @default.
• W3010852673 cites W2021119852 @default.
• W3010852673 cites W2026616100 @default.
• W3010852673 cites W2051101627 @default.
• W3010852673 cites W2061324080 @default.
• W3010852673 cites W2063795240 @default.
• W3010852673 cites W2070828096 @default.
• W3010852673 cites W2072296702 @default.
• W3010852673 cites W2081237186 @default.
• W3010852673 cites W2099527308 @default.
• W3010852673 cites W2114613490 @default.
• W3010852673 cites W2132969335 @default.
• W3010852673 cites W2151821422 @default.
• W3010852673 cites W2606960287 @default.
• W3010852673 cites W2763173694 @default.
• W3010852673 cites W2777987555 @default.
• W3010852673 cites W2791876368 @default.
• W3010852673 cites W2797629049 @default.
• W3010852673 cites W2887951509 @default.
• W3010852673 cites W2897729977 @default.
• W3010852673 cites W2946507767 @default.
• W3010852673 cites W2946619175 @default.
• W3010852673 cites W2947326735 @default.
• W3010852673 cites W2969290450 @default.
• W3010852673 cites W2996346053 @default.
• W3010852673 cites W2996631414 @default.
• W3010852673 doi "https://doi.org/10.1016/j.brs.2020.03.006" @default.
• W3010852673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32417668" @default.
• W3010852673 hasPublicationYear "2020" @default.
• W3010852673 type Work @default.
• W3010852673 sameAs 3010852673 @default.
• W3010852673 citedByCount "17" @default.
• W3010852673 countsByYear W30108526732020 @default.
• W3010852673 countsByYear W30108526732021 @default.
• W3010852673 countsByYear W30108526732022 @default.
• W3010852673 countsByYear W30108526732023 @default.
• W3010852673 crossrefType "journal-article" @default.
• W3010852673 hasAuthorship W3010852673A5005367845 @default.
• W3010852673 hasAuthorship W3010852673A5034742107 @default.
• W3010852673 hasAuthorship W3010852673A5043095653 @default.
• W3010852673 hasAuthorship W3010852673A5047922852 @default.
• W3010852673 hasAuthorship W3010852673A5055960648 @default.
• W3010852673 hasAuthorship W3010852673A5056904269 @default.
• W3010852673 hasAuthorship W3010852673A5063029101 @default.
• W3010852673 hasBestOaLocation W30108526731 @default.
• W3010852673 hasConcept C126322002 @default.
• W3010852673 hasConcept C126838900 @default.
• W3010852673 hasConcept C143409427 @default.
• W3010852673 hasConcept C149550507 @default.
• W3010852673 hasConcept C15744967 @default.
• W3010852673 hasConcept C169760540 @default.
• W3010852673 hasConcept C24998067 @default.
• W3010852673 hasConcept C2777193593 @default.
• W3010852673 hasConcept C2777342061 @default.
• W3010852673 hasConcept C2778542668 @default.
• W3010852673 hasConcept C2779134260 @default.
• W3010852673 hasConcept C2779144063 @default.
• W3010852673 hasConcept C2779734285 @default.
• W3010852673 hasConcept C2780051608 @default.
• W3010852673 hasConcept C2781192897 @default.
• W3010852673 hasConcept C71924100 @default.
• W3010852673 hasConcept C89916169 @default.
• W3010852673 hasConceptScore W3010852673C126322002 @default.
• W3010852673 hasConceptScore W3010852673C126838900 @default.
• W3010852673 hasConceptScore W3010852673C143409427 @default.
• W3010852673 hasConceptScore W3010852673C149550507 @default.
• W3010852673 hasConceptScore W3010852673C15744967 @default.
• W3010852673 hasConceptScore W3010852673C169760540 @default.
• W3010852673 hasConceptScore W3010852673C24998067 @default.
• W3010852673 hasConceptScore W3010852673C2777193593 @default.
• W3010852673 hasConceptScore W3010852673C2777342061 @default.
• W3010852673 hasConceptScore W3010852673C2778542668 @default.
• W3010852673 hasConceptScore W3010852673C2779134260 @default.
• W3010852673 hasConceptScore W3010852673C2779144063 @default.
• W3010852673 hasConceptScore W3010852673C2779734285 @default.
• W3010852673 hasConceptScore W3010852673C2780051608 @default.
• W3010852673 hasConceptScore W3010852673C2781192897 @default.
• W3010852673 hasConceptScore W3010852673C71924100 @default.
• W3010852673 hasConceptScore W3010852673C89916169 @default.
• W3010852673 hasFunder F4320319927 @default.
• W3010852673 hasFunder F4320332161 @default.
• W3010852673 hasIssue "4" @default.
• W3010852673 hasLocation W30108526731 @default.

• next