FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010869908> ?p ?o ?g. }

• W3010869908 endingPage "748" @default.
• W3010869908 startingPage "727" @default.
• W3010869908 abstract "Aging-induced functional and phenotypic alterations of the vasculature (e.g., endothelial dysfunction, oxidative stress) have a central role in morbidity and mortality of older adults. It has become apparent in recent years that cell autonomous mechanisms alone are inadequate to explain all aspects of vascular aging. The present study was designed to test the hypothesis that age-related changes in circulating anti-geronic factors contribute to the regulation of vascular aging processes in a non-cell autonomous manner. To test this hypothesis, through heterochronic parabiosis we determined the extent, if any, to which endothelial function, vascular production of ROS, and shifts in the vascular transcriptome (RNA-seq) are modulated by the systemic environment. We found that in aortas isolated from isochronic parabiont aged (20-month-old) C57BL/6 mice [A-(A); parabiosis for 8 weeks] acetylcholine-induced endothelium-dependent relaxation was impaired and ROS production (dihydroethidium fluorescence) was increased as compared with those in aortas from young isochronic parabiont (6-month-old) mice [Y-(Y)]. The presence of young blood derived from young parabionts significantly improved endothelium-dependent vasorelaxation and attenuated ROS production in vessels of heterochronic parabiont aged [A-(Y)] mice. In aortas derived from heterochronic parabiont young [Y-(A)] mice, acetylcholine-induced relaxation and ROS production were comparable with those in aortas derived from Y-(Y) mice. Using RNA-seq we assessed transcriptomic changes in the aortic arch associated with aging and heterochronic parabiosis. We identified 347 differentially expressed genes in A-(A) animals compared with Y-(Y) controls. We have identified 212 discordant genes, whose expression levels differed in the aged phenotype, but have shifted back toward the young phenotype by the presence of young blood in aged A-(Y) animals. Pathway analysis shows that vascular protective effects mediated by young blood-regulated genes include mitochondrial rejuvenation. In conclusion, a relatively short-term exposure to young blood can rescue vascular aging phenotypes, including attenuation of oxidative stress, mitochondrial rejuvenation, and improved endothelial function. Our findings provide additional evidence supporting the significant plasticity of vascular aging and evidence for the existence of anti-geronic factors capable of exerting rejuvenating effects on the aging vasculature." @default.
• W3010869908 created "2020-03-23" @default.
• W3010869908 creator A5000383566 @default.
• W3010869908 creator A5002131258 @default.
• W3010869908 creator A5006115537 @default.
• W3010869908 creator A5020208515 @default.
• W3010869908 creator A5021282382 @default.
• W3010869908 creator A5021351628 @default.
• W3010869908 creator A5042577204 @default.
• W3010869908 creator A5051353131 @default.
• W3010869908 creator A5059163570 @default.
• W3010869908 creator A5084691311 @default.
• W3010869908 creator A5088990934 @default.
• W3010869908 date "2020-03-15" @default.
• W3010869908 modified "2023-10-17" @default.
• W3010869908 title "Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood" @default.
• W3010869908 cites W1492660023 @default.
• W3010869908 cites W1577963762 @default.
• W3010869908 cites W1589837828 @default.
• W3010869908 cites W1593887887 @default.
• W3010869908 cites W1617304195 @default.
• W3010869908 cites W1760390524 @default.
• W3010869908 cites W1785188086 @default.
• W3010869908 cites W1809682088 @default.
• W3010869908 cites W1832678746 @default.
• W3010869908 cites W1842937689 @default.
• W3010869908 cites W1888932721 @default.
• W3010869908 cites W1902236642 @default.
• W3010869908 cites W1965575508 @default.
• W3010869908 cites W1968982667 @default.
• W3010869908 cites W1969905245 @default.
• W3010869908 cites W1973758090 @default.
• W3010869908 cites W1976365705 @default.
• W3010869908 cites W1978927200 @default.
• W3010869908 cites W1988236300 @default.
• W3010869908 cites W1989277387 @default.
• W3010869908 cites W1993970594 @default.
• W3010869908 cites W1995724928 @default.
• W3010869908 cites W1997567380 @default.
• W3010869908 cites W1998004606 @default.
• W3010869908 cites W2006471292 @default.
• W3010869908 cites W2006496068 @default.
• W3010869908 cites W2007193535 @default.
• W3010869908 cites W2012095775 @default.
• W3010869908 cites W2016998058 @default.
• W3010869908 cites W2018221430 @default.
• W3010869908 cites W2018451691 @default.
• W3010869908 cites W2029494483 @default.
• W3010869908 cites W2032790009 @default.
• W3010869908 cites W2041553669 @default.
• W3010869908 cites W2041749675 @default.
• W3010869908 cites W2045949302 @default.
• W3010869908 cites W2047538260 @default.
• W3010869908 cites W2048963838 @default.
• W3010869908 cites W2049206418 @default.
• W3010869908 cites W2054670968 @default.
• W3010869908 cites W2059278059 @default.
• W3010869908 cites W2067028731 @default.
• W3010869908 cites W2067460515 @default.
• W3010869908 cites W2067976787 @default.
• W3010869908 cites W2069439580 @default.
• W3010869908 cites W2069519394 @default.
• W3010869908 cites W2073192909 @default.
• W3010869908 cites W2076619948 @default.
• W3010869908 cites W2078419347 @default.
• W3010869908 cites W2082030974 @default.
• W3010869908 cites W2090442368 @default.
• W3010869908 cites W2091478649 @default.
• W3010869908 cites W2097750015 @default.
• W3010869908 cites W2097857054 @default.
• W3010869908 cites W2099023692 @default.
• W3010869908 cites W2100317831 @default.
• W3010869908 cites W2104394381 @default.
• W3010869908 cites W2106635206 @default.
• W3010869908 cites W2106996966 @default.
• W3010869908 cites W2107804869 @default.
• W3010869908 cites W2108887402 @default.
• W3010869908 cites W2114215135 @default.
• W3010869908 cites W2115813376 @default.
• W3010869908 cites W2118597422 @default.
• W3010869908 cites W2122073743 @default.
• W3010869908 cites W2125002495 @default.
• W3010869908 cites W2125817440 @default.
• W3010869908 cites W2126525177 @default.
• W3010869908 cites W2128979080 @default.
• W3010869908 cites W2130410032 @default.
• W3010869908 cites W2131271579 @default.
• W3010869908 cites W2134160158 @default.
• W3010869908 cites W2136256348 @default.
• W3010869908 cites W2138255346 @default.
• W3010869908 cites W2142688267 @default.
• W3010869908 cites W2144261101 @default.
• W3010869908 cites W2145082590 @default.
• W3010869908 cites W2150073419 @default.
• W3010869908 cites W2152149843 @default.
• W3010869908 cites W2154874811 @default.
• W3010869908 cites W2155109825 @default.
• W3010869908 cites W2155937098 @default.

• next