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- W3010872784 abstract "e15572 Background: Participant accrual is a critical benchmark in clinical research, predicting study completion and reflecting the perceived value of the clinical question and study designed to answer it. Timely accrual data can be used prospectively to inform the design of new clinical trials. Accrual statistics are available within research networks, such as the cancer cooperative groups, but comprehensive data reflecting the overall portfolio of cancer clinical trials are lacking. As a demonstration case, we tested the availability of accrual data across all recent renal cell carcinoma (RCC) studies. Methods: The database for the Aggregate Analysis of ClinicalTrials.gov (CTG) summarizes all trials registered between 10/2007-9/2010. 137 RCC trials were included, of which 108 focused on pharmacologic therapy. Accrual data on these trials were gathered from CTG, online surveys sent to principle investigators, trial coordinators, and/or industry sponsors, review of resulting publications, and follow up phone calls to non-responders. Results: 20 of 76 (26%) trials listing a government, academic, or cooperative group (GAC) sponsor responded to the survey vs 0 of 32 (0%) of those listing only industry (I) sponsors. Across all methods, accrual data were collected for 43 trials (40%), including 28 of 76 (37%) GAC trials and 15 of 32 (47%) I trials. 87% of GAC trials which were ongoing (open, actively recruiting, or of unknown status) vs 75% of I trials. 10 of 108 trials (9%) were closed prematurely. Conclusions: Despite extensive efforts (surveys, phone calls, CTG abstraction, publication searches), accurate accrual data remained inaccessible for 60% of the RCC trial cohort. While CTG reports trial results, ongoing accrual data are also critically needed. Poor access to accrual data will continue to limit attempts to develop a national summary of clinical trials metrics and to optimize the cancer clinical research portfolio. [Table: see text]" @default.
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- W3010872784 date "2013-05-20" @default.
- W3010872784 modified "2023-09-28" @default.
- W3010872784 title "Inadequate data availability on clinical trial accrual and its effect on progress in cancer research." @default.
- W3010872784 doi "https://doi.org/10.1200/jco.2013.31.15_suppl.e15572" @default.
- W3010872784 hasPublicationYear "2013" @default.
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