FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010872864> ?p ?o ?g. }

• W3010872864 abstract "Ependymoma (EPN) is rare primary tumor of central nervous system that affects both children and adults. Despite definition and classification of distinct molecular subgroups, there remains a group of EPNs with a balanced genome, which makes it difficult to predict prognosis of patients with EPN. The role of miRNA-mRNA network on EPN is still poorly understood. We assessed involvement of miRNA-mRNA pairs in EPN by applying weighted co-expression network analysis (WGCNA) approach. Using whole genome expression profile analysis followed by functional enrichment, we detected hub genes involved in active proliferation and DNA replication of nerve cells. Key genes including CYP11B1, KRT33B, RUNX1T1, SIK1, MAP3K4, MLANA and SFRP5 identified in co-expression network were regulated by miR-15a and miR-24-1. This seven miRNA-mRNA pairs were considered to influence not only pathways in cancer and tumor suppression process, but also MAPK, NF-kappaB and WNT signaling pathways which were associated with tumorigenesis and development. This study provides novel insight into potential diagnostic biomarkers of EPN and may have a value in choosing therapeutic targets with clinical utility." @default.
• W3010872864 created "2020-03-23" @default.
• W3010872864 creator A5025077602 @default.
• W3010872864 creator A5049600037 @default.
• W3010872864 creator A5080992183 @default.
• W3010872864 creator A5083791713 @default.
• W3010872864 date "2020-03-19" @default.
• W3010872864 modified "2023-09-24" @default.
• W3010872864 title "Investigation of miRNA and mRNA Co-expression Network in Ependymoma" @default.
• W3010872864 cites W144423133 @default.
• W3010872864 cites W1490161904 @default.
• W3010872864 cites W160155574 @default.
• W3010872864 cites W1648301895 @default.
• W3010872864 cites W1966327575 @default.
• W3010872864 cites W1974254202 @default.
• W3010872864 cites W1980324442 @default.
• W3010872864 cites W1982102069 @default.
• W3010872864 cites W1983821957 @default.
• W3010872864 cites W1992387879 @default.
• W3010872864 cites W1995477513 @default.
• W3010872864 cites W2001544973 @default.
• W3010872864 cites W2009593134 @default.
• W3010872864 cites W2012462812 @default.
• W3010872864 cites W2015785639 @default.
• W3010872864 cites W2016090899 @default.
• W3010872864 cites W2020277292 @default.
• W3010872864 cites W2022779434 @default.
• W3010872864 cites W2026570544 @default.
• W3010872864 cites W2058006073 @default.
• W3010872864 cites W2061558152 @default.
• W3010872864 cites W2066030073 @default.
• W3010872864 cites W2101882540 @default.
• W3010872864 cites W2102589798 @default.
• W3010872864 cites W2112055300 @default.
• W3010872864 cites W2112309180 @default.
• W3010872864 cites W2124960242 @default.
• W3010872864 cites W2146512944 @default.
• W3010872864 cites W2159482845 @default.
• W3010872864 cites W2162674813 @default.
• W3010872864 cites W2262414037 @default.
• W3010872864 cites W2266413788 @default.
• W3010872864 cites W2289602271 @default.
• W3010872864 cites W2295455218 @default.
• W3010872864 cites W2366536035 @default.
• W3010872864 cites W2406306690 @default.
• W3010872864 cites W2467042444 @default.
• W3010872864 cites W2474747771 @default.
• W3010872864 cites W2530011614 @default.
• W3010872864 cites W2586359658 @default.
• W3010872864 cites W2601456473 @default.
• W3010872864 cites W2614125124 @default.
• W3010872864 cites W2755883283 @default.
• W3010872864 cites W2755895540 @default.
• W3010872864 cites W2763504136 @default.
• W3010872864 cites W2763556680 @default.
• W3010872864 cites W2766427259 @default.
• W3010872864 cites W2771615866 @default.
• W3010872864 cites W2808293799 @default.
• W3010872864 cites W2809238127 @default.
• W3010872864 cites W2887476278 @default.
• W3010872864 cites W2888250792 @default.
• W3010872864 cites W2888593364 @default.
• W3010872864 cites W2894848101 @default.
• W3010872864 cites W2947186274 @default.
• W3010872864 cites W2952700880 @default.
• W3010872864 cites W2956207900 @default.
• W3010872864 cites W2959063704 @default.
• W3010872864 cites W2971128767 @default.
• W3010872864 cites W2973686658 @default.
• W3010872864 cites W2974045261 @default.
• W3010872864 cites W2982360975 @default.
• W3010872864 cites W2983508622 @default.
• W3010872864 cites W4294216483 @default.
• W3010872864 doi "https://doi.org/10.3389/fbioe.2020.00177" @default.
• W3010872864 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7096354" @default.
• W3010872864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32266223" @default.
• W3010872864 hasPublicationYear "2020" @default.
• W3010872864 type Work @default.
• W3010872864 sameAs 3010872864 @default.
• W3010872864 citedByCount "12" @default.
• W3010872864 countsByYear W30108728642021 @default.
• W3010872864 countsByYear W30108728642022 @default.
• W3010872864 crossrefType "journal-article" @default.
• W3010872864 hasAuthorship W3010872864A5025077602 @default.
• W3010872864 hasAuthorship W3010872864A5049600037 @default.
• W3010872864 hasAuthorship W3010872864A5080992183 @default.
• W3010872864 hasAuthorship W3010872864A5083791713 @default.
• W3010872864 hasBestOaLocation W30108728641 @default.
• W3010872864 hasConcept C104317684 @default.
• W3010872864 hasConcept C105580179 @default.
• W3010872864 hasConcept C121608353 @default.
• W3010872864 hasConcept C137620995 @default.
• W3010872864 hasConcept C142724271 @default.
• W3010872864 hasConcept C145059251 @default.
• W3010872864 hasConcept C150194340 @default.
• W3010872864 hasConcept C2781432949 @default.
• W3010872864 hasConcept C502942594 @default.
• W3010872864 hasConcept C54355233 @default.
• W3010872864 hasConcept C555283112 @default.
• W3010872864 hasConcept C60644358 @default.

• next