Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010873190> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W3010873190 abstract "Abstract. Interstrand crosslinks (ICLs) occur when two complimentary strands of DNA are covalentlylinked together after exposure to crosslinking agents, therefore blocking the processes essential for cellsurvival such as DNA transcription, replication and recombination by preventing the strand separationand switching cell fate to apoptosis. Taking advantage of it, chemical agents such as cisplatin, mitomycinC and nitrogen mustards are widely used in chemotherapy against cancer and several hyperplasic diseases. However, cellular responses induced by ICLs and repair mechanisms counteracting their cytotoxiceffect can lead to the appearance of acquired resistance in cancer cells thus limiting the efficiency of thetreatment. In this review, we will discuss the main properties of several classes of ICL-forming agents andrecent advances in our understanding of the mechanisms of ICL repair. Due to the recent developmentson the repair mechanisms of various ICLs, our insight has broadened regarding the drug-specific formation and cellular processing of ICLs. Even though the main features of ICL repair remained the same, newplayers of repair machinery acting upon specific ICLs are being discovered. These new findings mayfurnish a basis to improve and adapt anticancer therapies by targeting DNA repair pathways in order tocounteract the development of resistance to anti-cancer treatments.Key words: DNA repair, oxidative stress, DNA crosslinks" @default.
- W3010873190 created "2020-03-23" @default.
- W3010873190 creator A5006660467 @default.
- W3010873190 creator A5033963530 @default.
- W3010873190 creator A5064506934 @default.
- W3010873190 date "2019-12-22" @default.
- W3010873190 modified "2023-10-18" @default.
- W3010873190 title "Repair of interstrand DNA crosslinks induced by oxidative stress and anti-cancer agents" @default.
- W3010873190 doi "https://doi.org/10.26577/eje.2019.v61.i4.01" @default.
- W3010873190 hasPublicationYear "2019" @default.
- W3010873190 type Work @default.
- W3010873190 sameAs 3010873190 @default.
- W3010873190 citedByCount "0" @default.
- W3010873190 crossrefType "journal-article" @default.
- W3010873190 hasAuthorship W3010873190A5006660467 @default.
- W3010873190 hasAuthorship W3010873190A5033963530 @default.
- W3010873190 hasAuthorship W3010873190A5064506934 @default.
- W3010873190 hasConcept C121608353 @default.
- W3010873190 hasConcept C127413603 @default.
- W3010873190 hasConcept C134935766 @default.
- W3010873190 hasConcept C143425029 @default.
- W3010873190 hasConcept C185592680 @default.
- W3010873190 hasConcept C188198153 @default.
- W3010873190 hasConcept C190283241 @default.
- W3010873190 hasConcept C2776151105 @default.
- W3010873190 hasConcept C2776694085 @default.
- W3010873190 hasConcept C2778239845 @default.
- W3010873190 hasConcept C502942594 @default.
- W3010873190 hasConcept C54355233 @default.
- W3010873190 hasConcept C552990157 @default.
- W3010873190 hasConcept C55493867 @default.
- W3010873190 hasConcept C60748783 @default.
- W3010873190 hasConcept C73573662 @default.
- W3010873190 hasConcept C78519656 @default.
- W3010873190 hasConcept C86803240 @default.
- W3010873190 hasConcept C95444343 @default.
- W3010873190 hasConcept C96232424 @default.
- W3010873190 hasConceptScore W3010873190C121608353 @default.
- W3010873190 hasConceptScore W3010873190C127413603 @default.
- W3010873190 hasConceptScore W3010873190C134935766 @default.
- W3010873190 hasConceptScore W3010873190C143425029 @default.
- W3010873190 hasConceptScore W3010873190C185592680 @default.
- W3010873190 hasConceptScore W3010873190C188198153 @default.
- W3010873190 hasConceptScore W3010873190C190283241 @default.
- W3010873190 hasConceptScore W3010873190C2776151105 @default.
- W3010873190 hasConceptScore W3010873190C2776694085 @default.
- W3010873190 hasConceptScore W3010873190C2778239845 @default.
- W3010873190 hasConceptScore W3010873190C502942594 @default.
- W3010873190 hasConceptScore W3010873190C54355233 @default.
- W3010873190 hasConceptScore W3010873190C552990157 @default.
- W3010873190 hasConceptScore W3010873190C55493867 @default.
- W3010873190 hasConceptScore W3010873190C60748783 @default.
- W3010873190 hasConceptScore W3010873190C73573662 @default.
- W3010873190 hasConceptScore W3010873190C78519656 @default.
- W3010873190 hasConceptScore W3010873190C86803240 @default.
- W3010873190 hasConceptScore W3010873190C95444343 @default.
- W3010873190 hasConceptScore W3010873190C96232424 @default.
- W3010873190 hasLocation W30108731901 @default.
- W3010873190 hasOpenAccess W3010873190 @default.
- W3010873190 hasPrimaryLocation W30108731901 @default.
- W3010873190 hasRelatedWork W10324709 @default.
- W3010873190 hasRelatedWork W15388267 @default.
- W3010873190 hasRelatedWork W16805844 @default.
- W3010873190 hasRelatedWork W21260246 @default.
- W3010873190 hasRelatedWork W25604659 @default.
- W3010873190 hasRelatedWork W30613834 @default.
- W3010873190 hasRelatedWork W33843931 @default.
- W3010873190 hasRelatedWork W36399790 @default.
- W3010873190 hasRelatedWork W37091630 @default.
- W3010873190 hasRelatedWork W7042538 @default.
- W3010873190 isParatext "false" @default.
- W3010873190 isRetracted "false" @default.
- W3010873190 magId "3010873190" @default.
- W3010873190 workType "article" @default.