FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010877608> ?p ?o ?g. }

• W3010877608 endingPage "126467" @default.
• W3010877608 startingPage "126467" @default.
• W3010877608 abstract "Tris (1,3-dichloro-2-propyl)phosphate (TDCPP) is an organophosphate-based plasticizer and flame retardant with a high production volume. The ubiquitous distribution and persistence of TDCPP in aquatic environment have led to concerns over its possible toxic effects on aquatic organism. However, data regarding the toxicity of TDCPP on algae are limited, and the molecular mechanism remains largely unknown. Therefore, we determined the growth characteristics, physiological changes and transcriptome profiles of Phaeodactylum tricornutum in response to 4 mg L −1 TDCPP for 24 h. TDCPP caused morphological damage and growth inhibition with an EC 50 value of 3.71 mg L −1 at 96 h. A decline in pigments and photosynthetic activity was observed, indicating the occurrence of photosynthesis inhibition. Although the activities of both glutathione peroxidase and glutathione reductase were stimulated, oxidative stress was not relieved in the algal cells, as evidenced by the elevated levels of reactive oxygen species and lipid peroxidation. Transcriptomic analyses revealed 3312 differentially expressed genes (DEGs), and photosynthesis was a key target, as genes related to this process were greatly altered under TDCPP stress. Moreover, some DEGs were also enriched in amino acid metabolism, nitrogen metabolism, nucleotide metabolism and lipid metabolism, implying that TDCPP-induced damage towards algae by various pathways. Additionally, several TFs related to stress signaling were differentially expressed, suggesting roles in the TDCPP stress response. The results will provide critical data to understand the ecological risks and toxic mechanism of OPFRs entering into marine habitat. • TDCPP inhibited the growth of P. tricornutum. • Photosynthesis may be a key TDCPP target. • TDCPP induced an imbalance between ROS defense system and oxidative stress. • TDCPP regulated some TFs related to stress signaling." @default.
• W3010877608 created "2020-03-23" @default.
• W3010877608 creator A5000510528 @default.
• W3010877608 creator A5024827245 @default.
• W3010877608 creator A5035441171 @default.
• W3010877608 creator A5038099360 @default.
• W3010877608 creator A5052206167 @default.
• W3010877608 creator A5083613663 @default.
• W3010877608 creator A5084630072 @default.
• W3010877608 date "2020-08-01" @default.
• W3010877608 modified "2023-10-15" @default.
• W3010877608 title "Toxic effect and mechanism of tris (1,3-dichloro-2-propyl)phosphate (TDCPP) on the marine alga Phaeodactylum tricornutum" @default.
• W3010877608 cites W1567616744 @default.
• W3010877608 cites W1968656423 @default.
• W3010877608 cites W1970701469 @default.
• W3010877608 cites W1972140706 @default.
• W3010877608 cites W1998061900 @default.
• W3010877608 cites W2014275427 @default.
• W3010877608 cites W2014508814 @default.
• W3010877608 cites W2018079770 @default.
• W3010877608 cites W2021360384 @default.
• W3010877608 cites W2021591445 @default.
• W3010877608 cites W2033836533 @default.
• W3010877608 cites W2035825693 @default.
• W3010877608 cites W2040125628 @default.
• W3010877608 cites W2046171022 @default.
• W3010877608 cites W2052827499 @default.
• W3010877608 cites W2056239863 @default.
• W3010877608 cites W2067914062 @default.
• W3010877608 cites W2068651431 @default.
• W3010877608 cites W2086323013 @default.
• W3010877608 cites W2092487810 @default.
• W3010877608 cites W2116259487 @default.
• W3010877608 cites W2118519973 @default.
• W3010877608 cites W2126386203 @default.
• W3010877608 cites W2129939060 @default.
• W3010877608 cites W2131036864 @default.
• W3010877608 cites W2131271579 @default.
• W3010877608 cites W2140791826 @default.
• W3010877608 cites W2142580874 @default.
• W3010877608 cites W2168464188 @default.
• W3010877608 cites W2190012449 @default.
• W3010877608 cites W2227470438 @default.
• W3010877608 cites W2282557535 @default.
• W3010877608 cites W2289743977 @default.
• W3010877608 cites W2327269145 @default.
• W3010877608 cites W2419530695 @default.
• W3010877608 cites W2519301668 @default.
• W3010877608 cites W2613301759 @default.
• W3010877608 cites W2617839927 @default.
• W3010877608 cites W2618878949 @default.
• W3010877608 cites W2647255167 @default.
• W3010877608 cites W2750958293 @default.
• W3010877608 cites W2775416219 @default.
• W3010877608 cites W2854997967 @default.
• W3010877608 cites W2888318318 @default.
• W3010877608 cites W2909580600 @default.
• W3010877608 cites W2912535854 @default.
• W3010877608 cites W405915105 @default.
• W3010877608 cites W784780859 @default.
• W3010877608 doi "https://doi.org/10.1016/j.chemosphere.2020.126467" @default.
• W3010877608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32222518" @default.
• W3010877608 hasPublicationYear "2020" @default.
• W3010877608 type Work @default.
• W3010877608 sameAs 3010877608 @default.
• W3010877608 citedByCount "11" @default.
• W3010877608 countsByYear W30108776082021 @default.
• W3010877608 countsByYear W30108776082022 @default.
• W3010877608 countsByYear W30108776082023 @default.
• W3010877608 crossrefType "journal-article" @default.
• W3010877608 hasAuthorship W3010877608A5000510528 @default.
• W3010877608 hasAuthorship W3010877608A5024827245 @default.
• W3010877608 hasAuthorship W3010877608A5035441171 @default.
• W3010877608 hasAuthorship W3010877608A5038099360 @default.
• W3010877608 hasAuthorship W3010877608A5052206167 @default.
• W3010877608 hasAuthorship W3010877608A5083613663 @default.
• W3010877608 hasAuthorship W3010877608A5084630072 @default.
• W3010877608 hasConcept C104317684 @default.
• W3010877608 hasConcept C150194340 @default.
• W3010877608 hasConcept C162317418 @default.
• W3010877608 hasConcept C181199279 @default.
• W3010877608 hasConcept C183688256 @default.
• W3010877608 hasConcept C185592680 @default.
• W3010877608 hasConcept C2776151105 @default.
• W3010877608 hasConcept C2780655307 @default.
• W3010877608 hasConcept C2780829032 @default.
• W3010877608 hasConcept C48349386 @default.
• W3010877608 hasConcept C538909803 @default.
• W3010877608 hasConcept C55493867 @default.
• W3010877608 hasConcept C559758991 @default.
• W3010877608 hasConcept C59822182 @default.
• W3010877608 hasConcept C62231903 @default.
• W3010877608 hasConcept C86803240 @default.
• W3010877608 hasConceptScore W3010877608C104317684 @default.
• W3010877608 hasConceptScore W3010877608C150194340 @default.
• W3010877608 hasConceptScore W3010877608C162317418 @default.
• W3010877608 hasConceptScore W3010877608C181199279 @default.
• W3010877608 hasConceptScore W3010877608C183688256 @default.

• next