Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010887084> ?p ?o ?g. }
- W3010887084 endingPage "109926" @default.
- W3010887084 startingPage "109926" @default.
- W3010887084 abstract "The tendency to engage in addictive behaviors has long been tied to the actions of the dopamine system. Early theories were based on the fact that all addictive drugs and behaviors (such as gambling) increase dopamine levels in the striatum, and the evidence that dopamine signaled reward or reward prediction error. However, with a changing emphasis of addiction away from purely pharmacological models that emphasize tolerance and withdrawal, towards one of behavioral dyscontrol, is there still a place for abnormal dopamine signaling in addiction? Here we recast the dopamine theory of addiction based on the idea that tonic dopamine may index a continuous phenotype that goes from apathy to impulsivity and compulsivity. Higher tonic dopamine signaling would make individuals vulnerable to drug reinforcement and cue-induced craving. We relate this to computational models of dopamine signaling, and review clinical and neuroimaging evidence from Parkinson’s Disease, schizophrenia and bipolar disorder in support of this model." @default.
- W3010887084 created "2020-03-23" @default.
- W3010887084 creator A5009187908 @default.
- W3010887084 creator A5025048708 @default.
- W3010887084 creator A5029787846 @default.
- W3010887084 creator A5054295358 @default.
- W3010887084 date "2020-07-01" @default.
- W3010887084 modified "2023-10-16" @default.
- W3010887084 title "From apathy to addiction: Insights from neurology and psychiatry" @default.
- W3010887084 cites W1501501601 @default.
- W3010887084 cites W1506567021 @default.
- W3010887084 cites W1518890501 @default.
- W3010887084 cites W1577320427 @default.
- W3010887084 cites W1620712071 @default.
- W3010887084 cites W1827984733 @default.
- W3010887084 cites W1877542283 @default.
- W3010887084 cites W1932737332 @default.
- W3010887084 cites W1936785944 @default.
- W3010887084 cites W1965686771 @default.
- W3010887084 cites W1969089145 @default.
- W3010887084 cites W1970135881 @default.
- W3010887084 cites W1971999279 @default.
- W3010887084 cites W1976284302 @default.
- W3010887084 cites W1976921288 @default.
- W3010887084 cites W1981732081 @default.
- W3010887084 cites W1982821021 @default.
- W3010887084 cites W1983175610 @default.
- W3010887084 cites W1985029200 @default.
- W3010887084 cites W1987124362 @default.
- W3010887084 cites W1988159999 @default.
- W3010887084 cites W1989128259 @default.
- W3010887084 cites W1993790483 @default.
- W3010887084 cites W1995922883 @default.
- W3010887084 cites W1996327177 @default.
- W3010887084 cites W1997659839 @default.
- W3010887084 cites W1998274826 @default.
- W3010887084 cites W1998674360 @default.
- W3010887084 cites W1999635028 @default.
- W3010887084 cites W2001346075 @default.
- W3010887084 cites W2001613706 @default.
- W3010887084 cites W2002362120 @default.
- W3010887084 cites W2003314029 @default.
- W3010887084 cites W2003505635 @default.
- W3010887084 cites W2006757213 @default.
- W3010887084 cites W2009867055 @default.
- W3010887084 cites W2010073791 @default.
- W3010887084 cites W2014978670 @default.
- W3010887084 cites W2015640140 @default.
- W3010887084 cites W2015770890 @default.
- W3010887084 cites W2021831574 @default.
- W3010887084 cites W2022066531 @default.
- W3010887084 cites W2022185180 @default.
- W3010887084 cites W2026188485 @default.
- W3010887084 cites W2029087047 @default.
- W3010887084 cites W2030755872 @default.
- W3010887084 cites W2035547298 @default.
- W3010887084 cites W2038651825 @default.
- W3010887084 cites W2039891845 @default.
- W3010887084 cites W2040236122 @default.
- W3010887084 cites W2041219933 @default.
- W3010887084 cites W2042228032 @default.
- W3010887084 cites W2044815056 @default.
- W3010887084 cites W2046713808 @default.
- W3010887084 cites W2048024033 @default.
- W3010887084 cites W2048570082 @default.
- W3010887084 cites W2050353431 @default.
- W3010887084 cites W2052445433 @default.
- W3010887084 cites W2056112334 @default.
- W3010887084 cites W2058578514 @default.
- W3010887084 cites W2059888146 @default.
- W3010887084 cites W2060588252 @default.
- W3010887084 cites W2061257589 @default.
- W3010887084 cites W2062280179 @default.
- W3010887084 cites W2066848874 @default.
- W3010887084 cites W2069421990 @default.
- W3010887084 cites W2071370599 @default.
- W3010887084 cites W2073806182 @default.
- W3010887084 cites W2079767332 @default.
- W3010887084 cites W2079908656 @default.
- W3010887084 cites W2080914089 @default.
- W3010887084 cites W2085676043 @default.
- W3010887084 cites W2089415354 @default.
- W3010887084 cites W2096556047 @default.
- W3010887084 cites W2098445519 @default.
- W3010887084 cites W2098554817 @default.
- W3010887084 cites W2099173088 @default.
- W3010887084 cites W2101076435 @default.
- W3010887084 cites W2102305988 @default.
- W3010887084 cites W2103047614 @default.
- W3010887084 cites W2106862702 @default.
- W3010887084 cites W2111993699 @default.
- W3010887084 cites W2113219230 @default.
- W3010887084 cites W2113345170 @default.
- W3010887084 cites W2114520249 @default.
- W3010887084 cites W2114661800 @default.
- W3010887084 cites W2114862086 @default.
- W3010887084 cites W2114960031 @default.
- W3010887084 cites W2115062882 @default.