Matches in SemOpenAlex for { <https://semopenalex.org/work/W3010916240> ?p ?o ?g. }
- W3010916240 endingPage "835" @default.
- W3010916240 startingPage "835" @default.
- W3010916240 abstract "Context: As the food industry is continually involved in the development of new attractive alternative therapeutic agents, the evaluation of the beneficial impact of (poly)phenols on cognitive and brain function during aging has gained increasing interest. Objective: This systematic review and meta-analysis aimed to evaluate the acute and chronic effects of (poly)phenol-rich diet supplementation on cognitive function and brain health in aging adults. Data Sources: PubMed and Web of Science databases were searched for relevant randomized placebo-controlled trials (RCTs) published from inception to July 2019. Study Selection: Two researchers independently screened 4303 records, using the PICOS criteria: Participants were aging adults; Intervention was based on acute and/or chronic (poly)phenols-rich supplementation; Comparator was any comparator; Outcomes included cognitive function and neuroprotective measures; and Study design was RCTs. A third researcher was consulted when discrepancies arose. Fifteen high-quality (mean PEDro score = 8.8 ± 0.56) RCTs (total participants: 918 healthy older adults) were included in the final sample. Data Extraction: Information on study design, employed treatment, characteristics of participants, outcomes, and the correspondent assessing methods were extracted. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Data Analysis and Results: A random-effects meta-analysis was used to pool estimates across studies. Effect size (ES) and its 95% confidence interval (CI) was calculated. Pooled results yielded a trivial ES (−0.2 to 0.03) for brain-derived neurotrophic factor and neuroinflammatory parameters and small (0.36) to moderate (0.82) ES for executive functions. Conclusion: This meta-analysis failed to provide evidence regarding the neuroprotective and anti-inflammatory effect of (poly)phenols supplementation in aging adults. However, findings from individual studies, included in this systematic review, suggest polyphenol-rich supplementation may improve some cognitive and brain functions in older adults. The beneficial effect of polyphenols seems to depend on ingested dose and bioavailability. Results suggest at least an intermediate dose (≥500 mg), and intermediate (≈9%) to high (43%) bioavailability rates are needed to cross the brain blood barrier and to exert a significant effect on cognitive health." @default.
- W3010916240 created "2020-03-23" @default.
- W3010916240 creator A5000342861 @default.
- W3010916240 creator A5034843469 @default.
- W3010916240 creator A5034876923 @default.
- W3010916240 creator A5050787114 @default.
- W3010916240 creator A5052295935 @default.
- W3010916240 creator A5055943885 @default.
- W3010916240 creator A5059356428 @default.
- W3010916240 creator A5074046220 @default.
- W3010916240 creator A5090701697 @default.
- W3010916240 creator A5091125346 @default.
- W3010916240 creator A5091216466 @default.
- W3010916240 date "2020-03-19" @default.
- W3010916240 modified "2023-10-18" @default.
- W3010916240 title "The Effect of (Poly)phenol-Rich Interventions on Cognitive Functions and Neuroprotective Measures in Healthy Aging Adults: A Systematic Review and Meta-Analysis" @default.
- W3010916240 cites W1526755650 @default.
- W3010916240 cites W1660053632 @default.
- W3010916240 cites W1677815578 @default.
- W3010916240 cites W1914622032 @default.
- W3010916240 cites W1964435302 @default.
- W3010916240 cites W1965564902 @default.
- W3010916240 cites W1965783336 @default.
- W3010916240 cites W1972828058 @default.
- W3010916240 cites W1976365229 @default.
- W3010916240 cites W1977122148 @default.
- W3010916240 cites W1992045700 @default.
- W3010916240 cites W1999543531 @default.
- W3010916240 cites W1999891390 @default.
- W3010916240 cites W2009329132 @default.
- W3010916240 cites W2020794622 @default.
- W3010916240 cites W2033585778 @default.
- W3010916240 cites W2039518578 @default.
- W3010916240 cites W2041253289 @default.
- W3010916240 cites W2048616318 @default.
- W3010916240 cites W2052006054 @default.
- W3010916240 cites W2062934118 @default.
- W3010916240 cites W2067948657 @default.
- W3010916240 cites W2068359668 @default.
- W3010916240 cites W2074140237 @default.
- W3010916240 cites W2087243986 @default.
- W3010916240 cites W2100011555 @default.
- W3010916240 cites W2100377540 @default.
- W3010916240 cites W2102968146 @default.
- W3010916240 cites W2107837447 @default.
- W3010916240 cites W2107893450 @default.
- W3010916240 cites W2112299930 @default.
- W3010916240 cites W2116700603 @default.
- W3010916240 cites W2119331100 @default.
- W3010916240 cites W2125435699 @default.
- W3010916240 cites W2131742409 @default.
- W3010916240 cites W2138008191 @default.
- W3010916240 cites W2143058766 @default.
- W3010916240 cites W2144167844 @default.
- W3010916240 cites W2147089914 @default.
- W3010916240 cites W2152252699 @default.
- W3010916240 cites W2154033699 @default.
- W3010916240 cites W2154973070 @default.
- W3010916240 cites W2156098321 @default.
- W3010916240 cites W2157015549 @default.
- W3010916240 cites W2157823046 @default.
- W3010916240 cites W2160427616 @default.
- W3010916240 cites W2468996569 @default.
- W3010916240 cites W2510560444 @default.
- W3010916240 cites W2529181501 @default.
- W3010916240 cites W2538028846 @default.
- W3010916240 cites W2548664255 @default.
- W3010916240 cites W2591940733 @default.
- W3010916240 cites W2742107067 @default.
- W3010916240 cites W2744767678 @default.
- W3010916240 cites W2762916557 @default.
- W3010916240 cites W2779963293 @default.
- W3010916240 cites W2791606815 @default.
- W3010916240 cites W2795118157 @default.
- W3010916240 cites W2800767933 @default.
- W3010916240 cites W2803736447 @default.
- W3010916240 cites W2883166181 @default.
- W3010916240 cites W2883982486 @default.
- W3010916240 cites W2884088561 @default.
- W3010916240 cites W2888171838 @default.
- W3010916240 cites W2889787710 @default.
- W3010916240 cites W2897028787 @default.
- W3010916240 cites W2898318962 @default.
- W3010916240 cites W2913304950 @default.
- W3010916240 cites W2971709264 @default.
- W3010916240 cites W2974451935 @default.
- W3010916240 cites W2979733507 @default.
- W3010916240 cites W2999757271 @default.
- W3010916240 cites W3003231031 @default.
- W3010916240 cites W357675528 @default.
- W3010916240 doi "https://doi.org/10.3390/jcm9030835" @default.
- W3010916240 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7141326" @default.
- W3010916240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32204500" @default.
- W3010916240 hasPublicationYear "2020" @default.
- W3010916240 type Work @default.
- W3010916240 sameAs 3010916240 @default.
- W3010916240 citedByCount "21" @default.
- W3010916240 countsByYear W30109162402020 @default.