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- W3010932105 abstract "Abstract Introduction To determine whether vitamin B12 level at Parkinson's disease (PD) diagnosis predicts time to develop dementia. Methods We utilized a population-based cohort of Parkinsonism patients to examine the relationship between serum vitamin B12 at the time of PD diagnosis and dementia risk. Receiver operating curves were calculated for vitamin B12 cutoffs maximizing sensitivity and specificity for determining who developed dementia. Time from Parkinsonism diagnosis to dementia, death, or censoring was calculated utilizing Kaplan-Meier analysis and Cox-proportional hazard models. Results PD patients who did not develop dementia had higher baseline levels of vitamin B12 at PD diagnosis (648.5 ng/L vs 452 ng/L, p Conclusion Higher levels of serum vitamin B12 at PD diagnosis correlate with lower risk of future dementia. The role of vitamin B12 in the development of dementia among PD patients deserves further evaluation." @default.
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- W3010932105 date "2020-04-01" @default.
- W3010932105 modified "2023-09-24" @default.
- W3010932105 title "Higher vitamin B12 level at Parkinson's disease diagnosis is associated with lower risk of future dementia" @default.
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- W3010932105 doi "https://doi.org/10.1016/j.parkreldis.2020.03.009" @default.
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