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- W3010954817 abstract "Purpose: We investigated the effects of Quercetin and Coenzyme Q10 antioxidant, on gentamicin-induced renal failure in rats. Materials and Methods: The rats were given gentamicin (100 mg/kg/day, i.m., once a day), gentamicin (100 mg/kg/day, i.m.once a day) + Quercetin (15 mg/kg i.p. once a day) and gentamicin (100 mg/kg/day, i.m.) + Coenzyme Q10 (8 mg/kg i.m. once a day). Results: In control the BUN value was 26.8 ± 0.8 (mg/100 mL); whereas, it was 117.3 ± 15.4 in gentamicin group. Renal histopathologic examination confirmed acute tubular necrosis in this group. In rats treated with gentamicin + Quercetin and gentamicin + Coenzyme Q10, a partial improvement in biochemical and histologic parameters was observed. BUN values were 117.3 ± 15.4, 44.0 ± 8.3, 47.8 ± 13.8 in gentamicin, gentamicin plus Quercetin and gentamicin plus Coenzyme Q10 treated groups, respectively. Creatinine values were 4.3 ± 0.6, 0.8 ± 0.1, 1.5 ± 0.4 in gentamicin, gentamicin plus Quercetin and gentamicin plus Coenzyme Q10 treated groups, respectively. Conclusion: These results suggest that the administration of Quercetin and Coenzyme Q10 may have a protective effect on gentamicin-induced nephrotoxicity in rats." @default.
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- W3010954817 date "2020-03-31" @default.
- W3010954817 modified "2023-09-27" @default.
- W3010954817 title "Effects of Quercetin and Coenzyme Q10 on gentamicin-induced nephrotoxicity in rats" @default.
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- W3010954817 doi "https://doi.org/10.17826/cumj.648050" @default.
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