Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011010506> ?p ?o ?g. }
- W3011010506 endingPage "2495" @default.
- W3011010506 startingPage "2471" @default.
- W3011010506 abstract "As with other drugs or pharmaceuticals, opioids differ in their rewarding or analgesic effects depending on when they are applied. In the previous study, we have demonstrated the day/night difference in the sensitivity of the major circadian clock in the suprachiasmatic nucleus to a low dose of morphine, and showed the bidirectional effect of morphine on pERK1/2 and pGSK3β levels in the suprachiasmatic nucleus depending on the time of administration. The main aim of this study was to identify other brain structures that respond differently to morphine depending on the time of its administration. Using immunohistochemistry, we identified 44 structures that show time-of-day specific changes in c-Fos level and activity of ERK1/2 and GSK3β kinases in response to a single dose of 1 mg/kg morphine. Furthermore, comparison among control groups revealed the differences in the spontaneous levels of all markers with a generally higher level during the night, that is, in the active phase of the day. We thus provide further evidence for diurnal variations in the activity of brain regions outside the suprachiasmatic nucleus indicated by the temporal changes in the molecular substrate. We suggest that these changes are responsible for generating diurnal variation in the reward behavior or analgesic effect of opioid administration." @default.
- W3011010506 created "2020-03-23" @default.
- W3011010506 creator A5011998595 @default.
- W3011010506 creator A5041600627 @default.
- W3011010506 creator A5056634256 @default.
- W3011010506 date "2020-03-29" @default.
- W3011010506 modified "2023-10-17" @default.
- W3011010506 title "The day‐night differences in <scp>ERK1</scp>/2, <scp>GSK3β</scp> activity and <scp>c‐Fos</scp> levels in the brain, and the responsiveness of various brain structures to morphine" @default.
- W3011010506 cites W1463791314 @default.
- W3011010506 cites W1493209807 @default.
- W3011010506 cites W1529774113 @default.
- W3011010506 cites W1532805410 @default.
- W3011010506 cites W1565566868 @default.
- W3011010506 cites W1578507364 @default.
- W3011010506 cites W1590825385 @default.
- W3011010506 cites W1593547141 @default.
- W3011010506 cites W1606607758 @default.
- W3011010506 cites W1870380602 @default.
- W3011010506 cites W1918886067 @default.
- W3011010506 cites W1964839969 @default.
- W3011010506 cites W1966026592 @default.
- W3011010506 cites W1966815641 @default.
- W3011010506 cites W1967554979 @default.
- W3011010506 cites W1971846106 @default.
- W3011010506 cites W1973397362 @default.
- W3011010506 cites W1973430088 @default.
- W3011010506 cites W1974980511 @default.
- W3011010506 cites W1977289025 @default.
- W3011010506 cites W1977802871 @default.
- W3011010506 cites W1978793228 @default.
- W3011010506 cites W1978835714 @default.
- W3011010506 cites W1979435387 @default.
- W3011010506 cites W1989411375 @default.
- W3011010506 cites W1989505370 @default.
- W3011010506 cites W1989965906 @default.
- W3011010506 cites W1992553076 @default.
- W3011010506 cites W1996118505 @default.
- W3011010506 cites W1996997791 @default.
- W3011010506 cites W1997967560 @default.
- W3011010506 cites W1998006367 @default.
- W3011010506 cites W1999157874 @default.
- W3011010506 cites W2001008031 @default.
- W3011010506 cites W2002500468 @default.
- W3011010506 cites W2002564957 @default.
- W3011010506 cites W2003023920 @default.
- W3011010506 cites W2003921915 @default.
- W3011010506 cites W2004269416 @default.
- W3011010506 cites W2005926633 @default.
- W3011010506 cites W2007030810 @default.
- W3011010506 cites W2008355571 @default.
- W3011010506 cites W2008393308 @default.
- W3011010506 cites W2010709997 @default.
- W3011010506 cites W2012002548 @default.
- W3011010506 cites W2013515996 @default.
- W3011010506 cites W2019579728 @default.
- W3011010506 cites W2020286809 @default.
- W3011010506 cites W2020774650 @default.
- W3011010506 cites W2022467266 @default.
- W3011010506 cites W2024411580 @default.
- W3011010506 cites W2025431001 @default.
- W3011010506 cites W2028409372 @default.
- W3011010506 cites W2028852807 @default.
- W3011010506 cites W2029823386 @default.
- W3011010506 cites W2030934450 @default.
- W3011010506 cites W2031678730 @default.
- W3011010506 cites W2033892184 @default.
- W3011010506 cites W2035435760 @default.
- W3011010506 cites W2037994917 @default.
- W3011010506 cites W2039820148 @default.
- W3011010506 cites W2052599760 @default.
- W3011010506 cites W2054447293 @default.
- W3011010506 cites W2054611271 @default.
- W3011010506 cites W2055363053 @default.
- W3011010506 cites W2056918793 @default.
- W3011010506 cites W2057327437 @default.
- W3011010506 cites W2057817679 @default.
- W3011010506 cites W2059547815 @default.
- W3011010506 cites W2061411565 @default.
- W3011010506 cites W2064118699 @default.
- W3011010506 cites W2064318171 @default.
- W3011010506 cites W2067843226 @default.
- W3011010506 cites W2068812620 @default.
- W3011010506 cites W2070686944 @default.
- W3011010506 cites W2071923404 @default.
- W3011010506 cites W2073004752 @default.
- W3011010506 cites W2073148060 @default.
- W3011010506 cites W2075312117 @default.
- W3011010506 cites W2075715784 @default.
- W3011010506 cites W2078769183 @default.
- W3011010506 cites W2080935562 @default.
- W3011010506 cites W2083926404 @default.
- W3011010506 cites W2084694708 @default.
- W3011010506 cites W2085483223 @default.
- W3011010506 cites W2086482334 @default.
- W3011010506 cites W2087884526 @default.
- W3011010506 cites W2089901472 @default.
- W3011010506 cites W2089934560 @default.
- W3011010506 cites W2090763917 @default.