FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011036396> ?p ?o ?g. }

• W3011036396 abstract "The Shwachman-Bodian Diamond syndrome (SBDS)-associated gene, SBDS, is involved in rRNA synthesis and ribosome maturation, but the role of SBDS in cancer is largely elusive. In this study, we found that SBDS is often overexpressed or amplified in human cancers, and high level of endogenous SBDS is significantly associated with unfavorable prognosis. Conversely, knockdown of SBDS leads to p53 stabilization and activation through the ribosomal stress-RPL5/RPL11-MDM2 pathway, resulting in the repression of cancer cell proliferation and invasion. Interestingly, ectopic SBDS in the nucleoplasm also suppresses tumor cell growth and proliferation in vitro and in vivo. Mechanistically, ectopically expressed SBDS triggered by, for example, ribosomal stress binds to the transactivation domain of p53 and perturbs the MDM2-p53 interaction, consequently leading to impaired p53 ubiquitination and proteasomal degradation. Altogether, our finding for the first time demonstrates the dual functions of SBDS in cancer development by coordinating ribosome biogenesis and p53 activity." @default.
• W3011036396 created "2020-03-23" @default.
• W3011036396 creator A5003957341 @default.
• W3011036396 creator A5015501344 @default.
• W3011036396 creator A5029478416 @default.
• W3011036396 creator A5051960302 @default.
• W3011036396 creator A5055299862 @default.
• W3011036396 creator A5061151351 @default.
• W3011036396 creator A5091201374 @default.
• W3011036396 date "2020-03-20" @default.
• W3011036396 modified "2023-10-15" @default.
• W3011036396 title "Dual regulation of p53 by the ribosome maturation factor SBDS" @default.
• W3011036396 cites W1965173366 @default.
• W3011036396 cites W1976295398 @default.
• W3011036396 cites W1977966257 @default.
• W3011036396 cites W1980473722 @default.
• W3011036396 cites W1982494994 @default.
• W3011036396 cites W1992307025 @default.
• W3011036396 cites W1992989994 @default.
• W3011036396 cites W2007289968 @default.
• W3011036396 cites W2015859579 @default.
• W3011036396 cites W2021709122 @default.
• W3011036396 cites W2025722611 @default.
• W3011036396 cites W2040840144 @default.
• W3011036396 cites W2048642489 @default.
• W3011036396 cites W2049667730 @default.
• W3011036396 cites W2051035626 @default.
• W3011036396 cites W2056281827 @default.
• W3011036396 cites W2065774547 @default.
• W3011036396 cites W2066441178 @default.
• W3011036396 cites W2076282684 @default.
• W3011036396 cites W2079819818 @default.
• W3011036396 cites W2084454068 @default.
• W3011036396 cites W2097580481 @default.
• W3011036396 cites W2106220910 @default.
• W3011036396 cites W2106627064 @default.
• W3011036396 cites W2113570557 @default.
• W3011036396 cites W2114843025 @default.
• W3011036396 cites W2121166051 @default.
• W3011036396 cites W2128130126 @default.
• W3011036396 cites W2129104457 @default.
• W3011036396 cites W2132257713 @default.
• W3011036396 cites W2142994892 @default.
• W3011036396 cites W2149441684 @default.
• W3011036396 cites W2157155777 @default.
• W3011036396 cites W2411930441 @default.
• W3011036396 cites W2531294657 @default.
• W3011036396 cites W2548087847 @default.
• W3011036396 cites W2569552567 @default.
• W3011036396 cites W2752942423 @default.
• W3011036396 cites W2929402967 @default.
• W3011036396 cites W2958197380 @default.
• W3011036396 cites W625857439 @default.
• W3011036396 doi "https://doi.org/10.1038/s41419-020-2393-4" @default.
• W3011036396 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7083877" @default.
• W3011036396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32198344" @default.
• W3011036396 hasPublicationYear "2020" @default.
• W3011036396 type Work @default.
• W3011036396 sameAs 3011036396 @default.
• W3011036396 citedByCount "19" @default.
• W3011036396 countsByYear W30110363962020 @default.
• W3011036396 countsByYear W30110363962021 @default.
• W3011036396 countsByYear W30110363962022 @default.
• W3011036396 countsByYear W30110363962023 @default.
• W3011036396 crossrefType "journal-article" @default.
• W3011036396 hasAuthorship W3011036396A5003957341 @default.
• W3011036396 hasAuthorship W3011036396A5015501344 @default.
• W3011036396 hasAuthorship W3011036396A5029478416 @default.
• W3011036396 hasAuthorship W3011036396A5051960302 @default.
• W3011036396 hasAuthorship W3011036396A5055299862 @default.
• W3011036396 hasAuthorship W3011036396A5061151351 @default.
• W3011036396 hasAuthorship W3011036396A5091201374 @default.
• W3011036396 hasBestOaLocation W30110363961 @default.
• W3011036396 hasConcept C104317684 @default.
• W3011036396 hasConcept C1292079 @default.
• W3011036396 hasConcept C173396325 @default.
• W3011036396 hasConcept C2776192174 @default.
• W3011036396 hasConcept C2779419633 @default.
• W3011036396 hasConcept C502942594 @default.
• W3011036396 hasConcept C54355233 @default.
• W3011036396 hasConcept C62112901 @default.
• W3011036396 hasConcept C67705224 @default.
• W3011036396 hasConcept C86339819 @default.
• W3011036396 hasConcept C86803240 @default.
• W3011036396 hasConcept C88478588 @default.
• W3011036396 hasConcept C95444343 @default.
• W3011036396 hasConcept C97037327 @default.
• W3011036396 hasConceptScore W3011036396C104317684 @default.
• W3011036396 hasConceptScore W3011036396C1292079 @default.
• W3011036396 hasConceptScore W3011036396C173396325 @default.
• W3011036396 hasConceptScore W3011036396C2776192174 @default.
• W3011036396 hasConceptScore W3011036396C2779419633 @default.
• W3011036396 hasConceptScore W3011036396C502942594 @default.
• W3011036396 hasConceptScore W3011036396C54355233 @default.
• W3011036396 hasConceptScore W3011036396C62112901 @default.
• W3011036396 hasConceptScore W3011036396C67705224 @default.
• W3011036396 hasConceptScore W3011036396C86339819 @default.
• W3011036396 hasConceptScore W3011036396C86803240 @default.
• W3011036396 hasConceptScore W3011036396C88478588 @default.
• W3011036396 hasConceptScore W3011036396C95444343 @default.

• next