Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011040738> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W3011040738 endingPage "3581" @default.
- W3011040738 startingPage "3580" @default.
- W3011040738 abstract "Abstract Motivation T-cell receptors (TCRs) are immune proteins that primarily target peptide antigens presented by the major histocompatibility complex. They tend to have lower specificity and affinity than their antibody counterparts, and their binding sites have been shown to adopt multiple conformations, which is potentially an important factor for their polyspecificity. None of the current TCR-modelling tools predict this variability which limits our ability to accurately predict TCR binding. Results We present TCRBuilder, a multi-state TCR structure prediction tool. Given a paired αβTCR sequence, TCRBuilder returns a model or an ensemble of models covering the potential conformations of the binding site. This enables the analysis of structurally driven polyspecificity in TCRs, which is not possible with existing tools. Availability and implementation http://opig.stats.ox.ac.uk/resources. Contact deane@stats.ox.ac.uk Supplementary information Supplementary data are available at Bioinformatics online." @default.
- W3011040738 created "2020-03-23" @default.
- W3011040738 creator A5006452408 @default.
- W3011040738 creator A5014846122 @default.
- W3011040738 creator A5015572211 @default.
- W3011040738 creator A5054519833 @default.
- W3011040738 creator A5062359376 @default.
- W3011040738 creator A5064350904 @default.
- W3011040738 date "2020-03-17" @default.
- W3011040738 modified "2023-09-26" @default.
- W3011040738 title "TCRBuilder: multi-state T-cell receptor structure prediction" @default.
- W3011040738 cites W1481701911 @default.
- W3011040738 cites W2000779612 @default.
- W3011040738 cites W2017956110 @default.
- W3011040738 cites W2073392655 @default.
- W3011040738 cites W2146074801 @default.
- W3011040738 cites W2150345297 @default.
- W3011040738 cites W2474661075 @default.
- W3011040738 cites W2574510864 @default.
- W3011040738 cites W2766169371 @default.
- W3011040738 cites W2803170063 @default.
- W3011040738 cites W2951119766 @default.
- W3011040738 cites W2981124539 @default.
- W3011040738 doi "https://doi.org/10.1093/bioinformatics/btaa194" @default.
- W3011040738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32181809" @default.
- W3011040738 hasPublicationYear "2020" @default.
- W3011040738 type Work @default.
- W3011040738 sameAs 3011040738 @default.
- W3011040738 citedByCount "11" @default.
- W3011040738 countsByYear W30110407382020 @default.
- W3011040738 countsByYear W30110407382021 @default.
- W3011040738 countsByYear W30110407382022 @default.
- W3011040738 countsByYear W30110407382023 @default.
- W3011040738 crossrefType "journal-article" @default.
- W3011040738 hasAuthorship W3011040738A5006452408 @default.
- W3011040738 hasAuthorship W3011040738A5014846122 @default.
- W3011040738 hasAuthorship W3011040738A5015572211 @default.
- W3011040738 hasAuthorship W3011040738A5054519833 @default.
- W3011040738 hasAuthorship W3011040738A5062359376 @default.
- W3011040738 hasAuthorship W3011040738A5064350904 @default.
- W3011040738 hasBestOaLocation W30110407382 @default.
- W3011040738 hasConcept C147483822 @default.
- W3011040738 hasConcept C170493617 @default.
- W3011040738 hasConcept C19317047 @default.
- W3011040738 hasConcept C203014093 @default.
- W3011040738 hasConcept C207936829 @default.
- W3011040738 hasConcept C2776090121 @default.
- W3011040738 hasConcept C2778112365 @default.
- W3011040738 hasConcept C41008148 @default.
- W3011040738 hasConcept C54355233 @default.
- W3011040738 hasConcept C70721500 @default.
- W3011040738 hasConcept C86803240 @default.
- W3011040738 hasConcept C8891405 @default.
- W3011040738 hasConceptScore W3011040738C147483822 @default.
- W3011040738 hasConceptScore W3011040738C170493617 @default.
- W3011040738 hasConceptScore W3011040738C19317047 @default.
- W3011040738 hasConceptScore W3011040738C203014093 @default.
- W3011040738 hasConceptScore W3011040738C207936829 @default.
- W3011040738 hasConceptScore W3011040738C2776090121 @default.
- W3011040738 hasConceptScore W3011040738C2778112365 @default.
- W3011040738 hasConceptScore W3011040738C41008148 @default.
- W3011040738 hasConceptScore W3011040738C54355233 @default.
- W3011040738 hasConceptScore W3011040738C70721500 @default.
- W3011040738 hasConceptScore W3011040738C86803240 @default.
- W3011040738 hasConceptScore W3011040738C8891405 @default.
- W3011040738 hasIssue "11" @default.
- W3011040738 hasLocation W30110407381 @default.
- W3011040738 hasLocation W30110407382 @default.
- W3011040738 hasLocation W30110407383 @default.
- W3011040738 hasOpenAccess W3011040738 @default.
- W3011040738 hasPrimaryLocation W30110407381 @default.
- W3011040738 hasRelatedWork W1806734377 @default.
- W3011040738 hasRelatedWork W2026444950 @default.
- W3011040738 hasRelatedWork W2040128205 @default.
- W3011040738 hasRelatedWork W2060075608 @default.
- W3011040738 hasRelatedWork W2065755925 @default.
- W3011040738 hasRelatedWork W2582634194 @default.
- W3011040738 hasRelatedWork W2968803773 @default.
- W3011040738 hasRelatedWork W2979326653 @default.
- W3011040738 hasRelatedWork W3011040738 @default.
- W3011040738 hasRelatedWork W4368357399 @default.
- W3011040738 hasVolume "36" @default.
- W3011040738 isParatext "false" @default.
- W3011040738 isRetracted "false" @default.
- W3011040738 magId "3011040738" @default.
- W3011040738 workType "article" @default.