FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011051510> ?p ?o ?g. }

• W3011051510 abstract "Abstract Background Myelin sheaths surrounding axons are critical for electrical signal transmission in the central nervous system (CNS). Diseases with myelin defects such as multiple sclerosis (MS) are devastating neurological conditions for which few effective treatments are available. Dysfunction of the dopaminergic system has been observed in multiple neurological disorders. Its role in myelin pathogenesis, however, is unclear. Methods This work used a combination of literature curation, bioinformatics, pharmacological and genetic manipulation, as well as confocal imaging techniques. Literature search was used to establish a complete set of genes which is associated with MS in humans. Bioinformatics analyses include pathway enrichment and crosstalk analyses with human genetic association studies as well as gene set enrichment and causal relationship analyses with transcriptome data. Pharmacological and CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) genetic manipulation were applied to inhibit the dopaminergic signaling in zebrafish. Imaging techniques were used to visualize myelin formation in vivo . Results Systematic analysis of human genetic association studies revealed that the dopaminergic synapse signaling pathway is enriched in candidate gene sets. Transcriptome analysis confirmed that expression of multiple dopaminergic gene sets was significantly altered in patients with MS. Pathway crosstalk analysis and gene set causal relationship analysis reveal that the dopaminergic synapse signaling pathway interacts with or is associated with other critical pathways involved in MS. We also found that disruption of the dopaminergic system leads to myelin deficiency in zebrafish. Conclusions Dopaminergic signaling may be involved in myelin pathogenesis. This study may offer a novel molecular mechanism of demyelination in the nervous system." @default.
• W3011051510 created "2020-03-23" @default.
• W3011051510 creator A5004341581 @default.
• W3011051510 creator A5006507187 @default.
• W3011051510 creator A5018271028 @default.
• W3011051510 creator A5019906052 @default.
• W3011051510 creator A5031672922 @default.
• W3011051510 creator A5039314421 @default.
• W3011051510 creator A5042605058 @default.
• W3011051510 creator A5055576461 @default.
• W3011051510 creator A5057690102 @default.
• W3011051510 creator A5078490250 @default.
• W3011051510 date "2020-03-02" @default.
• W3011051510 modified "2023-09-23" @default.
• W3011051510 title "Integrative systems and functional analyses reveal a role of dopaminergic signaling in myelin pathogenesis" @default.
• W3011051510 cites W1498968758 @default.
• W3011051510 cites W1500818454 @default.
• W3011051510 cites W1560339503 @default.
• W3011051510 cites W1560595356 @default.
• W3011051510 cites W1604647162 @default.
• W3011051510 cites W1606673973 @default.
• W3011051510 cites W1968893068 @default.
• W3011051510 cites W1973717649 @default.
• W3011051510 cites W1974366107 @default.
• W3011051510 cites W1977780909 @default.
• W3011051510 cites W1978493362 @default.
• W3011051510 cites W1978526189 @default.
• W3011051510 cites W1980624172 @default.
• W3011051510 cites W1982024899 @default.
• W3011051510 cites W1985650014 @default.
• W3011051510 cites W1987492515 @default.
• W3011051510 cites W1992657248 @default.
• W3011051510 cites W1994469616 @default.
• W3011051510 cites W1999600164 @default.
• W3011051510 cites W2000293969 @default.
• W3011051510 cites W2027119123 @default.
• W3011051510 cites W2028817444 @default.
• W3011051510 cites W2040547343 @default.
• W3011051510 cites W2053411111 @default.
• W3011051510 cites W2058231627 @default.
• W3011051510 cites W2059111023 @default.
• W3011051510 cites W2062988576 @default.
• W3011051510 cites W2077764660 @default.
• W3011051510 cites W2078020097 @default.
• W3011051510 cites W2078699094 @default.
• W3011051510 cites W2080838942 @default.
• W3011051510 cites W2082363371 @default.
• W3011051510 cites W2082642969 @default.
• W3011051510 cites W2082688434 @default.
• W3011051510 cites W2090115746 @default.
• W3011051510 cites W2091960711 @default.
• W3011051510 cites W2095900642 @default.
• W3011051510 cites W2095929237 @default.
• W3011051510 cites W2110553827 @default.
• W3011051510 cites W2113624587 @default.
• W3011051510 cites W2114468018 @default.
• W3011051510 cites W2117663611 @default.
• W3011051510 cites W2123568853 @default.
• W3011051510 cites W2135277857 @default.
• W3011051510 cites W2137813387 @default.
• W3011051510 cites W2140933978 @default.
• W3011051510 cites W2142072527 @default.
• W3011051510 cites W2155899675 @default.
• W3011051510 cites W2158156478 @default.
• W3011051510 cites W2164298117 @default.
• W3011051510 cites W2359565797 @default.
• W3011051510 cites W2406880264 @default.
• W3011051510 cites W2549276155 @default.
• W3011051510 cites W2593011483 @default.
• W3011051510 cites W2604405632 @default.
• W3011051510 cites W2744104760 @default.
• W3011051510 cites W2755780856 @default.
• W3011051510 cites W2884440246 @default.
• W3011051510 cites W2905311230 @default.
• W3011051510 cites W4210961921 @default.
• W3011051510 doi "https://doi.org/10.1186/s12967-020-02276-1" @default.
• W3011051510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7053059" @default.
• W3011051510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32122379" @default.
• W3011051510 hasPublicationYear "2020" @default.
• W3011051510 type Work @default.
• W3011051510 sameAs 3011051510 @default.
• W3011051510 citedByCount "8" @default.
• W3011051510 countsByYear W30110515102020 @default.
• W3011051510 countsByYear W30110515102021 @default.
• W3011051510 countsByYear W30110515102022 @default.
• W3011051510 countsByYear W30110515102023 @default.
• W3011051510 crossrefType "journal-article" @default.
• W3011051510 hasAuthorship W3011051510A5004341581 @default.
• W3011051510 hasAuthorship W3011051510A5006507187 @default.
• W3011051510 hasAuthorship W3011051510A5018271028 @default.
• W3011051510 hasAuthorship W3011051510A5019906052 @default.
• W3011051510 hasAuthorship W3011051510A5031672922 @default.
• W3011051510 hasAuthorship W3011051510A5039314421 @default.
• W3011051510 hasAuthorship W3011051510A5042605058 @default.
• W3011051510 hasAuthorship W3011051510A5055576461 @default.
• W3011051510 hasAuthorship W3011051510A5057690102 @default.
• W3011051510 hasAuthorship W3011051510A5078490250 @default.
• W3011051510 hasBestOaLocation W30110515101 @default.
• W3011051510 hasConcept C104317684 @default.
• W3011051510 hasConcept C120665830 @default.

• next