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• W3011056653 abstract "Abstract Enzyme catalysis, enabled by advances in protein engineering and directed evolution, is beginning to transform chemical synthesis in the pharmaceutical industry. This review presents recent examples of the creative use of biocatalysis to enable drug discovery and development. We illustrate how increased access to novel biotransformations and the rise of cascade biocatalysis allowed fundamentally new syntheses of novel medicines, representing progress toward more sustainable pharmaceutical manufacturing. Finally, we describe the opportunities and challenges the industry must address to ensure the reduction to practice of biotechnological innovations to develop new therapies in a faster, more economical, and environmentally benign way." @default.
• W3011056653 created "2020-03-23" @default.
• W3011056653 creator A5018948897 @default.
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• W3011056653 date "2020-04-01" @default.
• W3011056653 modified "2023-10-11" @default.
• W3011056653 title "Biocatalysis in drug discovery and development" @default.
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• W3011056653 doi "https://doi.org/10.1016/j.cbpa.2020.01.012" @default.
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