FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011063981> ?p ?o ?g. }

• W3011063981 endingPage "e001107" @default.
• W3011063981 startingPage "e001107" @default.
• W3011063981 abstract "Objective Familial combined hyperlipidemia (FCHL) is common among survivors of a premature myocardial infarction. FCHL patients are characterized by visceral obesity, fatty liver, and insulin resistance. The aim of the present study was to determine the incidence and determinants of type 2 diabetes (T2D) in a longitudinal cohort of FCHL pedigrees. Research design and methods FCHL patients, their unaffected relatives and spouses included in our baseline cohort in 1998–2005 (n=596) were re-invited to determine the incidence of self-reported T2D (that was confirmed by medical records), used as the primary outcome measure. The Fatty Liver Index (FLI) and Homeostasis Model Assessment Insulin Resistance (HOMA2-IR) were used as markers of fatty liver and insulin resistance, respectively. A subset of the original cohort underwent ultrasound of the liver, and subcutaneous and visceral fat in 2002–2005 (n=275; ‘ultrasound subcohort’). Results Follow-up data (median: 15 years) was acquired for 76%. The incidence rate of T2D was significantly higher in FCHL patients compared with spouses (19.2 per 1000 person-years vs 2.8 per 1000 person-years; HR : 6.3, 95% CI: 2.4 to 16.8), whereas no differences were observed between unaffected relatives and spouses (HR: 0.9, 95% CI: 0.3 to 2.6). Cox’s proportional hazard regression analyses showed that baseline HOMA2-IR and FLI≥60, but not waist circumference, BMI, or the FCHL affected state, were independently associated with incident T2D. Similar results were obtained in the ultrasound subcohort (median follow-up: 11 years), in which baseline HOMA2-IR and fatty liver (assessed by ultrasound) were independently associated with incident T2D. Conclusion This study further corroborates the suggestion that the liver plays a central role in the pathogenesis of cardiometabolic complications in FCHL. It supports periodical screening for T2D in this high-risk population." @default.
• W3011063981 created "2020-03-23" @default.
• W3011063981 creator A5001305262 @default.
• W3011063981 creator A5010886974 @default.
• W3011063981 creator A5023966597 @default.
• W3011063981 creator A5029432554 @default.
• W3011063981 creator A5036306697 @default.
• W3011063981 creator A5044416324 @default.
• W3011063981 creator A5055462779 @default.
• W3011063981 creator A5058133438 @default.
• W3011063981 creator A5076487971 @default.
• W3011063981 creator A5079103905 @default.
• W3011063981 creator A5082886523 @default.
• W3011063981 creator A5083354546 @default.
• W3011063981 date "2020-03-01" @default.
• W3011063981 modified "2023-10-15" @default.
• W3011063981 title "Incidence of type 2 diabetes in familial combined hyperlipidemia" @default.
• W3011063981 cites W1574686390 @default.
• W3011063981 cites W1840251513 @default.
• W3011063981 cites W1967397221 @default.
• W3011063981 cites W1975453845 @default.
• W3011063981 cites W1983181715 @default.
• W3011063981 cites W1988205944 @default.
• W3011063981 cites W2003306047 @default.
• W3011063981 cites W2010895111 @default.
• W3011063981 cites W2025345283 @default.
• W3011063981 cites W2042024480 @default.
• W3011063981 cites W2051999166 @default.
• W3011063981 cites W2066898102 @default.
• W3011063981 cites W2071867050 @default.
• W3011063981 cites W2073609009 @default.
• W3011063981 cites W2077876793 @default.
• W3011063981 cites W2080763557 @default.
• W3011063981 cites W2083554930 @default.
• W3011063981 cites W2096629131 @default.
• W3011063981 cites W2109856873 @default.
• W3011063981 cites W2111946630 @default.
• W3011063981 cites W2125854867 @default.
• W3011063981 cites W2142802148 @default.
• W3011063981 cites W2143944818 @default.
• W3011063981 cites W2155725887 @default.
• W3011063981 cites W2164750952 @default.
• W3011063981 cites W2167130513 @default.
• W3011063981 cites W2334309509 @default.
• W3011063981 cites W2402599050 @default.
• W3011063981 cites W2736021487 @default.
• W3011063981 cites W2791409258 @default.
• W3011063981 cites W2899714334 @default.
• W3011063981 cites W3021842026 @default.
• W3011063981 doi "https://doi.org/10.1136/bmjdrc-2019-001107" @default.
• W3011063981 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7103854" @default.
• W3011063981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32193201" @default.
• W3011063981 hasPublicationYear "2020" @default.
• W3011063981 type Work @default.
• W3011063981 sameAs 3011063981 @default.
• W3011063981 citedByCount "12" @default.
• W3011063981 countsByYear W30110639812020 @default.
• W3011063981 countsByYear W30110639812021 @default.
• W3011063981 countsByYear W30110639812022 @default.
• W3011063981 countsByYear W30110639812023 @default.
• W3011063981 crossrefType "journal-article" @default.
• W3011063981 hasAuthorship W3011063981A5001305262 @default.
• W3011063981 hasAuthorship W3011063981A5010886974 @default.
• W3011063981 hasAuthorship W3011063981A5023966597 @default.
• W3011063981 hasAuthorship W3011063981A5029432554 @default.
• W3011063981 hasAuthorship W3011063981A5036306697 @default.
• W3011063981 hasAuthorship W3011063981A5044416324 @default.
• W3011063981 hasAuthorship W3011063981A5055462779 @default.
• W3011063981 hasAuthorship W3011063981A5058133438 @default.
• W3011063981 hasAuthorship W3011063981A5076487971 @default.
• W3011063981 hasAuthorship W3011063981A5079103905 @default.
• W3011063981 hasAuthorship W3011063981A5082886523 @default.
• W3011063981 hasAuthorship W3011063981A5083354546 @default.
• W3011063981 hasBestOaLocation W30110639811 @default.
• W3011063981 hasConcept C120665830 @default.
• W3011063981 hasConcept C121332964 @default.
• W3011063981 hasConcept C126322002 @default.
• W3011063981 hasConcept C134018914 @default.
• W3011063981 hasConcept C201903717 @default.
• W3011063981 hasConcept C207103383 @default.
• W3011063981 hasConcept C2777180221 @default.
• W3011063981 hasConcept C2777391703 @default.
• W3011063981 hasConcept C2780221984 @default.
• W3011063981 hasConcept C44249647 @default.
• W3011063981 hasConcept C511355011 @default.
• W3011063981 hasConcept C555293320 @default.
• W3011063981 hasConcept C61511704 @default.
• W3011063981 hasConcept C71924100 @default.
• W3011063981 hasConcept C72563966 @default.
• W3011063981 hasConcept C90924648 @default.
• W3011063981 hasConceptScore W3011063981C120665830 @default.
• W3011063981 hasConceptScore W3011063981C121332964 @default.
• W3011063981 hasConceptScore W3011063981C126322002 @default.
• W3011063981 hasConceptScore W3011063981C134018914 @default.
• W3011063981 hasConceptScore W3011063981C201903717 @default.
• W3011063981 hasConceptScore W3011063981C207103383 @default.
• W3011063981 hasConceptScore W3011063981C2777180221 @default.
• W3011063981 hasConceptScore W3011063981C2777391703 @default.

• next