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• W3011064846 abstract "ABSTRACT Background Human rhinovirus (HRV) is the most common cause of the common cold but may also lead to more severe respiratory illness in vulnerable populations. The epidemiology and genetic diversity of HRV within a school setting have not been described. Objective To characterise HRV molecular epidemiology among children attending primary school in a rural location of Kenya. Methods Between May 2017 to April 2018, over three school terms, we collected 1859 nasopharyngeal swabs (NPS) from pupils and teachers with symptoms of acute respiratory infection in a public primary school in Kilifi County, coastal Kenya. The samples were tested for HRV using real-time RT-PCR. HRV positive samples were sequenced in the VP4/VP2 coding region for species and genotype classification. Results A total of 307 NPS (16.4%) from 164 individuals were HRV positive, and 253 (82.4%) were successfully sequenced. The proportion of HRV in the lower primary classes was higher (19.8%) than upper primary classes (12.2%), p -value <0.001. HRV-A was the most common species (134/253, 53.0%), followed by HRV-C (73/253, 28.9%) and HRV-B (46/253, 18.2%). Phylogenetic analysis identified 47 HRV genotypes. The most common genotypes were A2 and B70. Numerous (up to 22 in one school term) genotypes circulated simultaneously, there was no individual re-infection with the same genotype, and no genotype was detected in all three school terms. Conclusion HRV was frequently detected among school-going children with mild ARI symptoms, and particularly in the younger age groups (<5-year-olds). Multiple HRV introductions were observed characterised by the considerable genotype diversity. Summary points We describe the molecular epidemiology of human rhinovirus (HRV) within a school setting over one-year in rural coastal Kenya. A high diversity of HRV infections was observed across all classes with evidence of introduction and transmission of 47 different genotypes." @default.
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• W3011064846 date "2020-03-12" @default.
• W3011064846 modified "2023-09-30" @default.
• W3011064846 title "Molecular epidemiology of human rhinovirus from one-year surveillance within a school setting in rural coastal Kenya" @default.
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• W3011064846 doi "https://doi.org/10.1101/2020.03.09.20033019" @default.
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