Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011094013> ?p ?o ?g. }
- W3011094013 endingPage "738" @default.
- W3011094013 startingPage "738" @default.
- W3011094013 abstract "Newly assembled herpesvirus nucleocapsids traverse the intact nuclear envelope by a vesicle-mediated nucleo-cytoplasmic transport for final virion maturation in the cytoplasm. For this, they bud at the inner nuclear membrane resulting in primary enveloped particles in the perinuclear space (PNS) followed by fusion of the primary envelope with the outer nuclear membrane (ONM). While the conserved viral nuclear egress complex orchestrates the first steps, effectors of fusion of the primary virion envelope with the ONM are still mostly enigmatic but might include cellular proteins like SUN2 or ESCRT-III components. Here, we analyzed the influence of the only known AAA+ ATPases located in the endoplasmic reticulum and the PNS, the Torsins (Tor), on nuclear egress of the alphaherpesvirus pseudorabies virus. For this overexpression of wild type and mutant proteins as well as CRISPR/Cas9 genome editing was applied. Neither single overexpression nor gene knockout (KO) of TorA or TorB had a significant impact. However, TorA/B double KO cells showed decreased viral titers at early time points of infection and an accumulation of primary virions in the PNS pointing to a delay in capsid release during nuclear egress." @default.
- W3011094013 created "2020-03-23" @default.
- W3011094013 creator A5005194409 @default.
- W3011094013 creator A5017599509 @default.
- W3011094013 creator A5020307296 @default.
- W3011094013 creator A5042822136 @default.
- W3011094013 creator A5049949632 @default.
- W3011094013 date "2020-03-17" @default.
- W3011094013 modified "2023-10-04" @default.
- W3011094013 title "Function of Torsin AAA+ ATPases in Pseudorabies Virus Nuclear Egress" @default.
- W3011094013 cites W1481225159 @default.
- W3011094013 cites W1496271097 @default.
- W3011094013 cites W1572140594 @default.
- W3011094013 cites W1805914897 @default.
- W3011094013 cites W1851148571 @default.
- W3011094013 cites W1875835053 @default.
- W3011094013 cites W1907539319 @default.
- W3011094013 cites W1965372133 @default.
- W3011094013 cites W1982049627 @default.
- W3011094013 cites W1983589934 @default.
- W3011094013 cites W1985880387 @default.
- W3011094013 cites W1989538493 @default.
- W3011094013 cites W1993960918 @default.
- W3011094013 cites W1995524264 @default.
- W3011094013 cites W1997720284 @default.
- W3011094013 cites W1998724633 @default.
- W3011094013 cites W2005641228 @default.
- W3011094013 cites W2010655741 @default.
- W3011094013 cites W2013436917 @default.
- W3011094013 cites W2021304970 @default.
- W3011094013 cites W2029208937 @default.
- W3011094013 cites W2033731029 @default.
- W3011094013 cites W2037933581 @default.
- W3011094013 cites W2043826253 @default.
- W3011094013 cites W2049711896 @default.
- W3011094013 cites W2059265460 @default.
- W3011094013 cites W2059291367 @default.
- W3011094013 cites W2067415425 @default.
- W3011094013 cites W2067455339 @default.
- W3011094013 cites W2069456643 @default.
- W3011094013 cites W2070989134 @default.
- W3011094013 cites W2074398793 @default.
- W3011094013 cites W2076167337 @default.
- W3011094013 cites W2076330310 @default.
- W3011094013 cites W2080523738 @default.
- W3011094013 cites W2099540110 @default.
- W3011094013 cites W2115407835 @default.
- W3011094013 cites W2119349019 @default.
- W3011094013 cites W2120055283 @default.
- W3011094013 cites W2120791711 @default.
- W3011094013 cites W2121431496 @default.
- W3011094013 cites W2124330160 @default.
- W3011094013 cites W2125745829 @default.
- W3011094013 cites W2130566610 @default.
- W3011094013 cites W2133119603 @default.
- W3011094013 cites W2138357022 @default.
- W3011094013 cites W2138395245 @default.
- W3011094013 cites W2139759270 @default.
- W3011094013 cites W2142404794 @default.
- W3011094013 cites W2150261685 @default.
- W3011094013 cites W2151256778 @default.
- W3011094013 cites W2158565708 @default.
- W3011094013 cites W2160146556 @default.
- W3011094013 cites W2162051595 @default.
- W3011094013 cites W2163504716 @default.
- W3011094013 cites W2166820447 @default.
- W3011094013 cites W2167279371 @default.
- W3011094013 cites W2168480092 @default.
- W3011094013 cites W2169705579 @default.
- W3011094013 cites W2191877372 @default.
- W3011094013 cites W2260787119 @default.
- W3011094013 cites W2293002570 @default.
- W3011094013 cites W2298507874 @default.
- W3011094013 cites W2522463027 @default.
- W3011094013 cites W2523806874 @default.
- W3011094013 cites W2540946284 @default.
- W3011094013 cites W2594608642 @default.
- W3011094013 cites W2737038670 @default.
- W3011094013 cites W2767782200 @default.
- W3011094013 cites W2770106458 @default.
- W3011094013 cites W2802183222 @default.
- W3011094013 cites W2806774648 @default.
- W3011094013 cites W2886575941 @default.
- W3011094013 cites W2908672819 @default.
- W3011094013 cites W2921722930 @default.
- W3011094013 cites W2955981549 @default.
- W3011094013 cites W2998947830 @default.
- W3011094013 cites W4250359879 @default.
- W3011094013 doi "https://doi.org/10.3390/cells9030738" @default.
- W3011094013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7140721" @default.
- W3011094013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32192107" @default.
- W3011094013 hasPublicationYear "2020" @default.
- W3011094013 type Work @default.
- W3011094013 sameAs 3011094013 @default.
- W3011094013 citedByCount "8" @default.
- W3011094013 countsByYear W30110940132021 @default.
- W3011094013 countsByYear W30110940132022 @default.
- W3011094013 countsByYear W30110940132023 @default.