Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011125832> ?p ?o ?g. }
- W3011125832 abstract "A hallmark of cancer is the disruption of cellular metabolism during the course of malignant growth. Major focus is now on how these cell-autonomous processes propagate to the tumor microenvironment and, more generally, to the entire host system. This chain of events can have major consequences for a patient's health and wellbeing. For example, metabolic waste produced by cancer cells activates systemic inflammatory responses, which can interfere with hepatic insulin receptor signaling and glucose homeostasis. Research is just now beginning to understand how these processes occur, and how they contribute to systemic symptoms prevalent across cancers, including hyperglycemia, fatigue, pain, and sleep disruption. Indeed, it is only recently that we have begun to appreciate that the brain does not play a passive role in responding to cancer-induced changes in physiology. In this review, we provide a brief discussion of how oncogene-directed metabolic reprogramming disrupts host metabolism, with a specific emphasis on cancer-induced hyperglycemia. We further discuss how the brain senses circulating glucose concentrations and how this process goes awry as a response to distant neoplastic growth. Finally, as glucose-sensing neurons control diverse aspects of physiology and behavior, we link cancer-induced changes in energy balance to neuroendocrine and behavioral consequences for the host organism." @default.
- W3011125832 created "2020-03-23" @default.
- W3011125832 creator A5043546771 @default.
- W3011125832 creator A5071008923 @default.
- W3011125832 date "2020-03-20" @default.
- W3011125832 modified "2023-09-26" @default.
- W3011125832 title "Neuroendocrine and Behavioral Consequences of Hyperglycemia in Cancer" @default.
- W3011125832 cites W1481893565 @default.
- W3011125832 cites W1509650655 @default.
- W3011125832 cites W1560846896 @default.
- W3011125832 cites W1698695320 @default.
- W3011125832 cites W1793127045 @default.
- W3011125832 cites W1891173294 @default.
- W3011125832 cites W1904885158 @default.
- W3011125832 cites W1957137659 @default.
- W3011125832 cites W1966234811 @default.
- W3011125832 cites W1969401286 @default.
- W3011125832 cites W1973839604 @default.
- W3011125832 cites W1975983146 @default.
- W3011125832 cites W1978082185 @default.
- W3011125832 cites W1978978516 @default.
- W3011125832 cites W1984467626 @default.
- W3011125832 cites W1986357169 @default.
- W3011125832 cites W1987363328 @default.
- W3011125832 cites W1989064410 @default.
- W3011125832 cites W1991655940 @default.
- W3011125832 cites W1993068187 @default.
- W3011125832 cites W1998093279 @default.
- W3011125832 cites W2002922559 @default.
- W3011125832 cites W2003093471 @default.
- W3011125832 cites W2003624944 @default.
- W3011125832 cites W2012121046 @default.
- W3011125832 cites W2016153546 @default.
- W3011125832 cites W2016536597 @default.
- W3011125832 cites W2016614559 @default.
- W3011125832 cites W2016758546 @default.
- W3011125832 cites W2017007251 @default.
- W3011125832 cites W2017625070 @default.
- W3011125832 cites W2023365378 @default.
- W3011125832 cites W2026418018 @default.
- W3011125832 cites W2027705428 @default.
- W3011125832 cites W2027740042 @default.
- W3011125832 cites W2031384783 @default.
- W3011125832 cites W2031462960 @default.
- W3011125832 cites W2033958147 @default.
- W3011125832 cites W2036578336 @default.
- W3011125832 cites W2037584745 @default.
- W3011125832 cites W2038089679 @default.
- W3011125832 cites W2039789253 @default.
- W3011125832 cites W2040235797 @default.
- W3011125832 cites W2040314977 @default.
- W3011125832 cites W2043957323 @default.
- W3011125832 cites W2044227662 @default.
- W3011125832 cites W2046300501 @default.
- W3011125832 cites W2054716401 @default.
- W3011125832 cites W2055348219 @default.
- W3011125832 cites W2056976841 @default.
- W3011125832 cites W2060878129 @default.
- W3011125832 cites W2063167079 @default.
- W3011125832 cites W2063632665 @default.
- W3011125832 cites W2065111656 @default.
- W3011125832 cites W2067041909 @default.
- W3011125832 cites W2068063361 @default.
- W3011125832 cites W2069588809 @default.
- W3011125832 cites W2069711307 @default.
- W3011125832 cites W2069897593 @default.
- W3011125832 cites W2079916202 @default.
- W3011125832 cites W2088507256 @default.
- W3011125832 cites W2088841065 @default.
- W3011125832 cites W2096591765 @default.
- W3011125832 cites W2102322990 @default.
- W3011125832 cites W2102364504 @default.
- W3011125832 cites W2111100731 @default.
- W3011125832 cites W2113585421 @default.
- W3011125832 cites W2117213785 @default.
- W3011125832 cites W2117568955 @default.
- W3011125832 cites W2118822805 @default.
- W3011125832 cites W2120292775 @default.
- W3011125832 cites W2124737580 @default.
- W3011125832 cites W2140013858 @default.
- W3011125832 cites W2143186704 @default.
- W3011125832 cites W2143609607 @default.
- W3011125832 cites W2145695033 @default.
- W3011125832 cites W2147050398 @default.
- W3011125832 cites W2148149831 @default.
- W3011125832 cites W2148658155 @default.
- W3011125832 cites W2151028899 @default.
- W3011125832 cites W2152211310 @default.
- W3011125832 cites W2155164261 @default.
- W3011125832 cites W2155248498 @default.
- W3011125832 cites W2155481474 @default.
- W3011125832 cites W2158993619 @default.
- W3011125832 cites W2169084376 @default.
- W3011125832 cites W2169214947 @default.
- W3011125832 cites W2198406525 @default.
- W3011125832 cites W2232778138 @default.
- W3011125832 cites W2234115940 @default.
- W3011125832 cites W2234438046 @default.
- W3011125832 cites W2264430018 @default.
- W3011125832 cites W2288987572 @default.