FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011133962> ?p ?o ?g. }

• W3011133962 abstract "Summary In cnidarians, axial patterning is not restricted to embryonic development but continues throughout a prolonged life history filled with unpredictable environmental changes. How this developmental capacity copes with fluctuations of food availability and whether it recapitulates embryonic mechanisms remain poorly understood. To address these questions, we utilize the tentacles of the sea anemone Nematostella vectensis as a novel paradigm for developmental patterning across distinct life history stages. As a result of embryonic development, Nematostella polyps feature four primary tentacles, while adults have 16 or more. By analyzing over 1000 growing polyps, we find that tentacle progression is remarkably stereotyped and occurs in a feeding-dependent manner. Mechanistically, we show that discrete Fibroblast growth factor receptor b ( Fgfrb )-positive ring muscles prefigure the sites of new tentacles in unfed polyps. In response to feeding, a Target of Rapamycin (TOR)-dependent mechanism controls the expansion of Fgfrb expression in oral tissues which defines tentacle primordia. Using a combination of genetic, cellular and molecular approaches, we demonstrate that FGFRb regionally enhances TOR signaling activity and promotes polarized growth, a spatial pattern that is restricted to polyp but not to embryonic tentacle primordia. These findings reveal an unexpected plasticity of tentacle development, and show that the crosstalk between TOR-mediated nutrient signaling and FGFRb pathway couples post-embryonic body patterning with food availability." @default.
• W3011133962 created "2020-03-23" @default.
• W3011133962 creator A5007455780 @default.
• W3011133962 creator A5013288754 @default.
• W3011133962 creator A5014528641 @default.
• W3011133962 creator A5060020117 @default.
• W3011133962 creator A5074566144 @default.
• W3011133962 creator A5080490535 @default.
• W3011133962 creator A5085741016 @default.
• W3011133962 date "2020-03-12" @default.
• W3011133962 modified "2023-09-27" @default.
• W3011133962 title "Feeding-dependent tentacle development in the sea anemone Nematostella vectensis" @default.
• W3011133962 cites W173536926 @default.
• W3011133962 cites W1784854092 @default.
• W3011133962 cites W1960441390 @default.
• W3011133962 cites W1986492978 @default.
• W3011133962 cites W1992388470 @default.
• W3011133962 cites W1992527906 @default.
• W3011133962 cites W2013668850 @default.
• W3011133962 cites W2016094835 @default.
• W3011133962 cites W2016719314 @default.
• W3011133962 cites W2018894650 @default.
• W3011133962 cites W2019679563 @default.
• W3011133962 cites W2027035529 @default.
• W3011133962 cites W2030545022 @default.
• W3011133962 cites W2042125299 @default.
• W3011133962 cites W2046213721 @default.
• W3011133962 cites W2071624678 @default.
• W3011133962 cites W2081565890 @default.
• W3011133962 cites W2088875348 @default.
• W3011133962 cites W2096081781 @default.
• W3011133962 cites W2099540110 @default.
• W3011133962 cites W2102078285 @default.
• W3011133962 cites W2106740149 @default.
• W3011133962 cites W2117223963 @default.
• W3011133962 cites W2121260094 @default.
• W3011133962 cites W2123470208 @default.
• W3011133962 cites W2127063807 @default.
• W3011133962 cites W2129622728 @default.
• W3011133962 cites W2138681393 @default.
• W3011133962 cites W2148777791 @default.
• W3011133962 cites W2154941408 @default.
• W3011133962 cites W2161580764 @default.
• W3011133962 cites W2168833201 @default.
• W3011133962 cites W2181665204 @default.
• W3011133962 cites W2182363306 @default.
• W3011133962 cites W2332205464 @default.
• W3011133962 cites W2402308439 @default.
• W3011133962 cites W2511464995 @default.
• W3011133962 cites W2734728802 @default.
• W3011133962 cites W2752262298 @default.
• W3011133962 cites W2755410496 @default.
• W3011133962 cites W2768128882 @default.
• W3011133962 cites W2787663275 @default.
• W3011133962 cites W2803977313 @default.
• W3011133962 cites W2807587036 @default.
• W3011133962 cites W2894367246 @default.
• W3011133962 cites W2912781291 @default.
• W3011133962 cites W2917315103 @default.
• W3011133962 cites W2937610428 @default.
• W3011133962 cites W2950662509 @default.
• W3011133962 cites W2952000840 @default.
• W3011133962 cites W2952266650 @default.
• W3011133962 doi "https://doi.org/10.1101/2020.03.12.985168" @default.
• W3011133962 hasPublicationYear "2020" @default.
• W3011133962 type Work @default.
• W3011133962 sameAs 3011133962 @default.
• W3011133962 citedByCount "0" @default.
• W3011133962 crossrefType "posted-content" @default.
• W3011133962 hasAuthorship W3011133962A5007455780 @default.
• W3011133962 hasAuthorship W3011133962A5013288754 @default.
• W3011133962 hasAuthorship W3011133962A5014528641 @default.
• W3011133962 hasAuthorship W3011133962A5060020117 @default.
• W3011133962 hasAuthorship W3011133962A5074566144 @default.
• W3011133962 hasAuthorship W3011133962A5080490535 @default.
• W3011133962 hasAuthorship W3011133962A5085741016 @default.
• W3011133962 hasBestOaLocation W30111339621 @default.
• W3011133962 hasConcept C104317684 @default.
• W3011133962 hasConcept C105702510 @default.
• W3011133962 hasConcept C145103041 @default.
• W3011133962 hasConcept C170493617 @default.
• W3011133962 hasConcept C184750944 @default.
• W3011133962 hasConcept C2775939778 @default.
• W3011133962 hasConcept C2778089062 @default.
• W3011133962 hasConcept C2779762311 @default.
• W3011133962 hasConcept C54355233 @default.
• W3011133962 hasConcept C59822182 @default.
• W3011133962 hasConcept C74373430 @default.
• W3011133962 hasConcept C86803240 @default.
• W3011133962 hasConcept C95444343 @default.
• W3011133962 hasConceptScore W3011133962C104317684 @default.
• W3011133962 hasConceptScore W3011133962C105702510 @default.
• W3011133962 hasConceptScore W3011133962C145103041 @default.
• W3011133962 hasConceptScore W3011133962C170493617 @default.
• W3011133962 hasConceptScore W3011133962C184750944 @default.
• W3011133962 hasConceptScore W3011133962C2775939778 @default.
• W3011133962 hasConceptScore W3011133962C2778089062 @default.
• W3011133962 hasConceptScore W3011133962C2779762311 @default.
• W3011133962 hasConceptScore W3011133962C54355233 @default.
• W3011133962 hasConceptScore W3011133962C59822182 @default.

• next