FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011170088> ?p ?o ?g. }

• W3011170088 abstract "We aimed to investigate the effects of Kruppel-like factor 5 (KLF5) on cell biological function and chemotherapy sensitivity of anaplastic thyroid carcinoma (ATC) and explore the underlying mechanism. In this study, we found that KLF5 was expressed higher in ATC cells than that in normal thyroid cells. Knockdown of KLF5 inhibited proliferation, induced apoptosis and restrained invasion and migration abilities of ATC cells. KLF5 overexpression promoted proliferation and inhibited apoptosis of ATC cells in response to doxorubicin (Dox), whereas KLF5 knockdown increased the sensitivity of ATC cells to Dox. Multidrug resistance gene 1/permeability glycoprotein and ATP-binding cassette superfamily G member 2 were heightened in ATC cells with KLF5 overexpression, but the opposite results were found in sh-KLF5-treated cells. Phosphorylation (p)-c-Jun N-terminal kinase (JNK) was upregulated in KLF5 overexpression cells, whereas it was downregulated in the KLF5 knockdown treatment group. Furthermore, KLF5 knockdown inhibited ATC growth and enhanced the Dox sensitivity of ATC by inactivating the JNK signaling pathway. Taken together, our findings concluded that KLF5 knockdown can remarkably inhibit the proliferation, invasion, and migration and induce apoptosis of ATC cells, and increase the chemotherapy sensitivity of ATC, all of which probably through inhibiting the JNK signaling pathway." @default.
• W3011170088 created "2020-03-23" @default.
• W3011170088 creator A5029554405 @default.
• W3011170088 creator A5049341927 @default.
• W3011170088 creator A5068548770 @default.
• W3011170088 creator A5090315068 @default.
• W3011170088 date "2020-03-15" @default.
• W3011170088 modified "2023-10-18" @default.
• W3011170088 title "KLF5 influences cell biological function and chemotherapy sensitivity through the JNK signaling pathway in anaplastic thyroid carcinoma" @default.
• W3011170088 cites W1541084139 @default.
• W3011170088 cites W1674293076 @default.
• W3011170088 cites W1818250344 @default.
• W3011170088 cites W1842226164 @default.
• W3011170088 cites W1968234999 @default.
• W3011170088 cites W1976683375 @default.
• W3011170088 cites W1991861950 @default.
• W3011170088 cites W1994435943 @default.
• W3011170088 cites W2003345186 @default.
• W3011170088 cites W2031600223 @default.
• W3011170088 cites W2032468149 @default.
• W3011170088 cites W2040042408 @default.
• W3011170088 cites W2041986831 @default.
• W3011170088 cites W2043850218 @default.
• W3011170088 cites W2044715980 @default.
• W3011170088 cites W2045376146 @default.
• W3011170088 cites W2053232173 @default.
• W3011170088 cites W2061219660 @default.
• W3011170088 cites W2064365978 @default.
• W3011170088 cites W2084472730 @default.
• W3011170088 cites W2085488377 @default.
• W3011170088 cites W2106685590 @default.
• W3011170088 cites W2173456406 @default.
• W3011170088 cites W2562398320 @default.
• W3011170088 cites W2584921798 @default.
• W3011170088 cites W2906669885 @default.
• W3011170088 cites W2910598438 @default.
• W3011170088 cites W2911552294 @default.
• W3011170088 cites W2935076315 @default.
• W3011170088 cites W2954525783 @default.
• W3011170088 doi "https://doi.org/10.1002/jbt.22469" @default.
• W3011170088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32173973" @default.
• W3011170088 hasPublicationYear "2020" @default.
• W3011170088 type Work @default.
• W3011170088 sameAs 3011170088 @default.
• W3011170088 citedByCount "4" @default.
• W3011170088 countsByYear W30111700882021 @default.
• W3011170088 countsByYear W30111700882022 @default.
• W3011170088 crossrefType "journal-article" @default.
• W3011170088 hasAuthorship W3011170088A5029554405 @default.
• W3011170088 hasAuthorship W3011170088A5049341927 @default.
• W3011170088 hasAuthorship W3011170088A5068548770 @default.
• W3011170088 hasAuthorship W3011170088A5090315068 @default.
• W3011170088 hasConcept C126322002 @default.
• W3011170088 hasConcept C127413603 @default.
• W3011170088 hasConcept C14036430 @default.
• W3011170088 hasConcept C143998085 @default.
• W3011170088 hasConcept C185592680 @default.
• W3011170088 hasConcept C21200559 @default.
• W3011170088 hasConcept C24326235 @default.
• W3011170088 hasConcept C2776694085 @default.
• W3011170088 hasConcept C2777546739 @default.
• W3011170088 hasConcept C2778981773 @default.
• W3011170088 hasConcept C2779761222 @default.
• W3011170088 hasConcept C2780256643 @default.
• W3011170088 hasConcept C502942594 @default.
• W3011170088 hasConcept C526584372 @default.
• W3011170088 hasConcept C55493867 @default.
• W3011170088 hasConcept C62478195 @default.
• W3011170088 hasConcept C71924100 @default.
• W3011170088 hasConcept C86803240 @default.
• W3011170088 hasConcept C95444343 @default.
• W3011170088 hasConceptScore W3011170088C126322002 @default.
• W3011170088 hasConceptScore W3011170088C127413603 @default.
• W3011170088 hasConceptScore W3011170088C14036430 @default.
• W3011170088 hasConceptScore W3011170088C143998085 @default.
• W3011170088 hasConceptScore W3011170088C185592680 @default.
• W3011170088 hasConceptScore W3011170088C21200559 @default.
• W3011170088 hasConceptScore W3011170088C24326235 @default.
• W3011170088 hasConceptScore W3011170088C2776694085 @default.
• W3011170088 hasConceptScore W3011170088C2777546739 @default.
• W3011170088 hasConceptScore W3011170088C2778981773 @default.
• W3011170088 hasConceptScore W3011170088C2779761222 @default.
• W3011170088 hasConceptScore W3011170088C2780256643 @default.
• W3011170088 hasConceptScore W3011170088C502942594 @default.
• W3011170088 hasConceptScore W3011170088C526584372 @default.
• W3011170088 hasConceptScore W3011170088C55493867 @default.
• W3011170088 hasConceptScore W3011170088C62478195 @default.
• W3011170088 hasConceptScore W3011170088C71924100 @default.
• W3011170088 hasConceptScore W3011170088C86803240 @default.
• W3011170088 hasConceptScore W3011170088C95444343 @default.
• W3011170088 hasIssue "5" @default.
• W3011170088 hasLocation W30111700881 @default.
• W3011170088 hasOpenAccess W3011170088 @default.
• W3011170088 hasPrimaryLocation W30111700881 @default.
• W3011170088 hasRelatedWork W114133454 @default.
• W3011170088 hasRelatedWork W159548391 @default.
• W3011170088 hasRelatedWork W2001447512 @default.
• W3011170088 hasRelatedWork W2046816389 @default.
• W3011170088 hasRelatedWork W2069968572 @default.
• W3011170088 hasRelatedWork W2095109709 @default.

• next