FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011191570> ?p ?o ?g. }

• W3011191570 endingPage "7254" @default.
• W3011191570 startingPage "7245" @default.
• W3011191570 abstract "Lens transparency is established by abundant accumulation of crystallin proteins and loss of organelles in the fiber cells. It requires an efficient translation of lens messenger RNAs (mRNAs) to overcome the progressively reduced transcriptional activity that results from denucleation. Inappropriate regulation of this process impairs lens differentiation and causes cataract formation. However, the regulatory mechanism promoting protein synthesis from lens-expressed mRNAs remains unclear. Here we show that in zebrafish, the RNA-binding protein Rbm24 is critically required for the accumulation of crystallin proteins and terminal differentiation of lens fiber cells. In the developing lens, Rbm24 binds to a wide spectrum of lens-specific mRNAs through the RNA recognition motif and interacts with cytoplasmic polyadenylation element-binding protein (Cpeb1b) and cytoplasmic poly(A)-binding protein (Pabpc1l) through the C-terminal region. Loss of Rbm24 reduces the stability of a subset of lens mRNAs encoding heat shock proteins and shortens the poly(A) tail length of crystallin mRNAs encoding lens structural components, thereby preventing their translation into functional proteins. This severely impairs lens transparency and results in blindness. Consistent with its highly conserved expression in differentiating lens fiber cells, the findings suggest that vertebrate Rbm24 represents a key regulator of cytoplasmic polyadenylation and plays an essential role in the posttranscriptional control of lens development." @default.
• W3011191570 created "2020-03-23" @default.
• W3011191570 creator A5012642496 @default.
• W3011191570 creator A5047835985 @default.
• W3011191570 creator A5050068568 @default.
• W3011191570 creator A5054514913 @default.
• W3011191570 creator A5058791842 @default.
• W3011191570 creator A5084906838 @default.
• W3011191570 date "2020-03-13" @default.
• W3011191570 modified "2023-10-15" @default.
• W3011191570 title "Rbm24 controls poly(A) tail length and translation efficiency of <i>crystallin</i> mRNAs in the lens via cytoplasmic polyadenylation" @default.
• W3011191570 cites W1499912034 @default.
• W3011191570 cites W1513212670 @default.
• W3011191570 cites W1964018236 @default.
• W3011191570 cites W1969207397 @default.
• W3011191570 cites W1977442761 @default.
• W3011191570 cites W1978107228 @default.
• W3011191570 cites W1978232581 @default.
• W3011191570 cites W1980556586 @default.
• W3011191570 cites W1983832084 @default.
• W3011191570 cites W1984574291 @default.
• W3011191570 cites W1995931397 @default.
• W3011191570 cites W2002071772 @default.
• W3011191570 cites W2019948507 @default.
• W3011191570 cites W2023324723 @default.
• W3011191570 cites W2025871346 @default.
• W3011191570 cites W2027212000 @default.
• W3011191570 cites W2036760181 @default.
• W3011191570 cites W2066828912 @default.
• W3011191570 cites W2067008047 @default.
• W3011191570 cites W2074396001 @default.
• W3011191570 cites W2076460258 @default.
• W3011191570 cites W2086963517 @default.
• W3011191570 cites W2100067283 @default.
• W3011191570 cites W2100377381 @default.
• W3011191570 cites W2105749202 @default.
• W3011191570 cites W2131142658 @default.
• W3011191570 cites W2133469451 @default.
• W3011191570 cites W2162986262 @default.
• W3011191570 cites W2168245648 @default.
• W3011191570 cites W2168990767 @default.
• W3011191570 cites W2175902342 @default.
• W3011191570 cites W2256899852 @default.
• W3011191570 cites W2295242434 @default.
• W3011191570 cites W2297199156 @default.
• W3011191570 cites W2305149488 @default.
• W3011191570 cites W2307520427 @default.
• W3011191570 cites W2346320382 @default.
• W3011191570 cites W2346373140 @default.
• W3011191570 cites W2408933165 @default.
• W3011191570 cites W2414628209 @default.
• W3011191570 cites W2520875945 @default.
• W3011191570 cites W2588815868 @default.
• W3011191570 cites W2699462664 @default.
• W3011191570 cites W2752838959 @default.
• W3011191570 cites W2760947301 @default.
• W3011191570 cites W2765581987 @default.
• W3011191570 cites W2789714056 @default.
• W3011191570 cites W2791414150 @default.
• W3011191570 cites W2887866682 @default.
• W3011191570 cites W2888453701 @default.
• W3011191570 cites W2894291799 @default.
• W3011191570 cites W2895797234 @default.
• W3011191570 cites W2903167102 @default.
• W3011191570 cites W2939869103 @default.
• W3011191570 cites W2995217890 @default.
• W3011191570 cites W4211229175 @default.
• W3011191570 cites W4379112825 @default.
• W3011191570 cites W7487991 @default.
• W3011191570 doi "https://doi.org/10.1073/pnas.1917922117" @default.
• W3011191570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7132282" @default.
• W3011191570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32170011" @default.
• W3011191570 hasPublicationYear "2020" @default.
• W3011191570 type Work @default.
• W3011191570 sameAs 3011191570 @default.
• W3011191570 citedByCount "36" @default.
• W3011191570 countsByYear W30111915702020 @default.
• W3011191570 countsByYear W30111915702021 @default.
• W3011191570 countsByYear W30111915702022 @default.
• W3011191570 countsByYear W30111915702023 @default.
• W3011191570 crossrefType "journal-article" @default.
• W3011191570 hasAuthorship W3011191570A5012642496 @default.
• W3011191570 hasAuthorship W3011191570A5047835985 @default.
• W3011191570 hasAuthorship W3011191570A5050068568 @default.
• W3011191570 hasAuthorship W3011191570A5054514913 @default.
• W3011191570 hasAuthorship W3011191570A5058791842 @default.
• W3011191570 hasAuthorship W3011191570A5084906838 @default.
• W3011191570 hasBestOaLocation W30111915701 @default.
• W3011191570 hasConcept C104317684 @default.
• W3011191570 hasConcept C105580179 @default.
• W3011191570 hasConcept C142575336 @default.
• W3011191570 hasConcept C149364088 @default.
• W3011191570 hasConcept C151730666 @default.
• W3011191570 hasConcept C15336307 @default.
• W3011191570 hasConcept C153911025 @default.
• W3011191570 hasConcept C190062978 @default.
• W3011191570 hasConcept C2776878037 @default.
• W3011191570 hasConcept C2780723820 @default.

• next