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• W3011236568 abstract "Abstract Ileal neuroendocrine tumors (I-NETs) are the most common tumors of the small intestine. Although I-NETs are known for a lack of recurrently mutated genes, a majority of tumors do show loss of one copy of chromosome 18. Among the genes on chromosome 18 is MIR1-2 , which encodes a microRNA, MIR1-3p, with high complementarity to the mRNA of CDK4 . Here we show that transfection of neuroendocrine cell lines with MIR1-3p lowered CDK4 expression and activity, and arrested growth at the G1 stage of the cell cycle. Loss of copy of MIR1-2 in ileal neuroendocrine tumors associated with increased expression of CDK4 . Genetic events that attenuated RB activity, including loss of copy of MIR1-2 as well as loss of copy of CDKN1B and CDKN2A , were more frequent in tumors from patients with metastatic I-NETs. These data suggest that inhibitors of CDK4/CDK6 may benefit patients whose I-NETs show loss of copy of MIR1-2 , particularly patients with metastatic disease." @default.
• W3011236568 created "2020-03-23" @default.
• W3011236568 creator A5038838969 @default.
• W3011236568 creator A5060332115 @default.
• W3011236568 date "2020-03-20" @default.
• W3011236568 modified "2023-10-17" @default.
• W3011236568 title "Loss of copy of MIR1-2 increases CDK4 expression in ileal neuroendocrine tumors" @default.
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• W3011236568 doi "https://doi.org/10.1038/s41389-020-0221-4" @default.
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