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- W30112375 abstract "In this chapter we provide an overview of stem cells in normal tissues as well as in many different types of cancers. All tissues in the body are derived from organ-specific stem cells that retain the ability to self-renew and differentiate into specific cell types. The cancer stem cell hypothesis suggests that tumors arise from cell populations with dysregulated self-renewal. This may be tissue stem cells or more differentiated cells that acquire self-renewal capabilities. In addition, we outline some useful assays for purification and isolation of cancer stem cells including the dye exclusion side population assay, flow cytometry sorting techniques for identification of putative cancer stem cell markers, tumorspheres assay, aldehyde dehydrogenase activity assay, PKH, and other membrane staining used to label the cancer stem cells, as well as in vivo xenograft transplantation assays. We also examine some of the cell signaling pathways that regulate stem cell self-renewal including the Notch, Hedgehog, HER2/PI3K/Akt/PTEN, and p53 pathways. We also review information demonstrating the involvement of the microenvironment or stem cell niche and its effects on the growth and maintenance of cancer stem cells. Finally, we highlight the therapeutic implications of targeting stem cells by inhibiting these pathways for the treatment and prevention of cancer." @default.
- W30112375 created "2016-06-24" @default.
- W30112375 creator A5034229775 @default.
- W30112375 creator A5059956218 @default.
- W30112375 date "2010-01-01" @default.
- W30112375 modified "2023-09-30" @default.
- W30112375 title "Stem Cells in Normal Development and Cancer" @default.
- W30112375 cites W106229536 @default.
- W30112375 cites W1513409266 @default.
- W30112375 cites W1608762409 @default.
- W30112375 cites W1614092612 @default.
- W30112375 cites W1660631781 @default.
- W30112375 cites W1675105744 @default.
- W30112375 cites W1676048097 @default.
- W30112375 cites W1831282506 @default.
- W30112375 cites W1916491745 @default.
- W30112375 cites W1963493384 @default.
- W30112375 cites W1964631913 @default.
- W30112375 cites W1965008951 @default.
- W30112375 cites W1965431780 @default.
- W30112375 cites W1965681567 @default.
- W30112375 cites W1966284659 @default.
- W30112375 cites W1967245224 @default.
- W30112375 cites W1967304777 @default.
- W30112375 cites W1968710367 @default.
- W30112375 cites W1968807484 @default.
- W30112375 cites W1969202196 @default.
- W30112375 cites W1969342869 @default.
- W30112375 cites W1969462288 @default.
- W30112375 cites W1974024530 @default.
- W30112375 cites W1974096298 @default.
- W30112375 cites W1975138724 @default.
- W30112375 cites W1976203623 @default.
- W30112375 cites W1976915106 @default.
- W30112375 cites W1977481263 @default.
- W30112375 cites W1977607560 @default.
- W30112375 cites W1977732674 @default.
- W30112375 cites W1977962361 @default.
- W30112375 cites W1979041271 @default.
- W30112375 cites W1979243197 @default.
- W30112375 cites W1979434317 @default.
- W30112375 cites W1979440527 @default.
- W30112375 cites W1981207071 @default.
- W30112375 cites W1983172551 @default.
- W30112375 cites W1983575387 @default.
- W30112375 cites W1984214021 @default.
- W30112375 cites W1985563073 @default.
- W30112375 cites W1986820364 @default.
- W30112375 cites W1989805762 @default.
- W30112375 cites W1990099538 @default.
- W30112375 cites W1990542926 @default.
- W30112375 cites W1992375116 @default.
- W30112375 cites W1992676863 @default.
- W30112375 cites W1992865216 @default.
- W30112375 cites W1993423043 @default.
- W30112375 cites W1994599132 @default.
- W30112375 cites W1995338672 @default.
- W30112375 cites W1997056190 @default.
- W30112375 cites W1999636129 @default.
- W30112375 cites W2000589976 @default.
- W30112375 cites W2001544973 @default.
- W30112375 cites W2002355858 @default.
- W30112375 cites W2003865749 @default.
- W30112375 cites W2004294452 @default.
- W30112375 cites W2004916479 @default.
- W30112375 cites W2006717309 @default.
- W30112375 cites W2008878539 @default.
- W30112375 cites W2009094422 @default.
- W30112375 cites W2009153189 @default.
- W30112375 cites W2009700765 @default.
- W30112375 cites W2009886857 @default.
- W30112375 cites W2010867675 @default.
- W30112375 cites W2012890384 @default.
- W30112375 cites W2013315155 @default.
- W30112375 cites W2014406829 @default.
- W30112375 cites W2016262183 @default.
- W30112375 cites W2017139179 @default.
- W30112375 cites W2018022325 @default.
- W30112375 cites W2018607339 @default.
- W30112375 cites W2019007505 @default.
- W30112375 cites W2019264784 @default.
- W30112375 cites W2019484386 @default.
- W30112375 cites W2019865561 @default.
- W30112375 cites W2020833650 @default.
- W30112375 cites W2023316892 @default.
- W30112375 cites W2023427658 @default.
- W30112375 cites W2024505724 @default.
- W30112375 cites W2026990179 @default.
- W30112375 cites W2028980412 @default.
- W30112375 cites W2029231546 @default.
- W30112375 cites W2030199762 @default.
- W30112375 cites W2030329983 @default.
- W30112375 cites W2031380629 @default.
- W30112375 cites W2032535754 @default.
- W30112375 cites W2033061169 @default.
- W30112375 cites W2035222904 @default.
- W30112375 cites W2037794296 @default.
- W30112375 cites W2037961348 @default.