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- W3011268210 endingPage "706" @default.
- W3011268210 startingPage "706" @default.
- W3011268210 abstract "The clinical success stories of chimeric antigen receptor (CAR)-T cell therapy against B-cell malignancies have contributed to immunotherapy being at the forefront of cancer therapy today. Their success has fueled interest in improving CAR constructs, identifying additional antigens to target, and clinically evaluating them across a wide range of malignancies. However, along with the exciting potential of CAR-T therapy comes the real possibility of serious side effects. While the FDA has approved commercialized CAR-T cell therapy, challenges associated with manufacturing, costs, and related toxicities have resulted in increased attention being paid to implementing CAR technology in innate cytotoxic natural killer (NK) cells. Here, we review the current landscape of the CAR-NK field, from successful clinical implementation to outstanding challenges which remain to be addressed to deliver the full potential of this therapy to more patients." @default.
- W3011268210 created "2020-03-23" @default.
- W3011268210 creator A5072700291 @default.
- W3011268210 creator A5082369585 @default.
- W3011268210 date "2020-03-17" @default.
- W3011268210 modified "2023-09-26" @default.
- W3011268210 title "You Have Got a Fast CAR: Chimeric Antigen Receptor NK Cells in Cancer Therapy" @default.
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