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- W3011294329 endingPage "100060" @default.
- W3011294329 startingPage "100060" @default.
- W3011294329 abstract "Parkinson’s disease (PD) is one of the most common neurodegenerative movement disorders which is characterised neuropathologically by progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the presence of Lewy bodies (made predominately of α-synuclein) in the surviving neurons. Animal models of PD have improved our understanding of the disease and have played a critical role in the development of neuroprotective agents. Neuroinflammation has been strongly implicated in the pathogenesis of PD, and recent studies have used lipopolysaccharide (LPS), a component of gram-negative bacteria and a potent activator of microglia cells, to mimic the inflammatory events in clinical PD. Modulating the inflammatory response could ameliorate PD associated complications and thus, it is essential to understand the extent to which LPS models reflect human PD. This review will outline the routes of administration of LPS such as stereotaxic, systemic and intranasal, their ability to recapitulate neuropathological markers of PD, and mechanisms of LPS induced toxicity. We will also discuss the ability of the models to replicate motor symptoms and non-motor symptoms of PD such as gastrointestinal dysfunction, olfactory dysfunction, anxiety, depression and cognitive dysfunction." @default.
- W3011294329 created "2020-03-23" @default.
- W3011294329 creator A5015239814 @default.
- W3011294329 creator A5033411400 @default.
- W3011294329 creator A5035738047 @default.
- W3011294329 creator A5041893045 @default.
- W3011294329 creator A5062886652 @default.
- W3011294329 date "2020-04-01" @default.
- W3011294329 modified "2023-10-16" @default.
- W3011294329 title "Lipopolysaccharide animal models of Parkinson’s disease: Recent progress and relevance to clinical disease" @default.
- W3011294329 cites W1502339857 @default.
- W3011294329 cites W1587360940 @default.
- W3011294329 cites W1629697287 @default.
- W3011294329 cites W1963577160 @default.
- W3011294329 cites W1966437242 @default.
- W3011294329 cites W1966905916 @default.
- W3011294329 cites W1971389338 @default.
- W3011294329 cites W1971599063 @default.
- W3011294329 cites W1973328205 @default.
- W3011294329 cites W1974924674 @default.
- W3011294329 cites W1975774284 @default.
- W3011294329 cites W1980020952 @default.
- W3011294329 cites W1982207977 @default.
- W3011294329 cites W1987183038 @default.
- W3011294329 cites W1987735399 @default.
- W3011294329 cites W1992780204 @default.
- W3011294329 cites W1995225441 @default.
- W3011294329 cites W1995281235 @default.
- W3011294329 cites W1997785893 @default.
- W3011294329 cites W1998743660 @default.
- W3011294329 cites W2001408101 @default.
- W3011294329 cites W2004349171 @default.
- W3011294329 cites W2004653921 @default.
- W3011294329 cites W2006754174 @default.
- W3011294329 cites W2008010082 @default.
- W3011294329 cites W2016709703 @default.
- W3011294329 cites W2017287105 @default.
- W3011294329 cites W2020621560 @default.
- W3011294329 cites W2021450573 @default.
- W3011294329 cites W2026982903 @default.
- W3011294329 cites W2030318357 @default.
- W3011294329 cites W2030748288 @default.
- W3011294329 cites W2036855925 @default.
- W3011294329 cites W2039190334 @default.
- W3011294329 cites W2040654348 @default.
- W3011294329 cites W2047701363 @default.
- W3011294329 cites W2051194668 @default.
- W3011294329 cites W2054817857 @default.
- W3011294329 cites W2055750901 @default.
- W3011294329 cites W2058653418 @default.
- W3011294329 cites W2062666762 @default.
- W3011294329 cites W2063285691 @default.
- W3011294329 cites W2069465895 @default.
- W3011294329 cites W2071655926 @default.
- W3011294329 cites W2081306572 @default.
- W3011294329 cites W2082682346 @default.
- W3011294329 cites W2086357928 @default.
- W3011294329 cites W2086779570 @default.
- W3011294329 cites W2087581370 @default.
- W3011294329 cites W2097703897 @default.
- W3011294329 cites W2100919899 @default.
- W3011294329 cites W2105047187 @default.
- W3011294329 cites W2108108635 @default.
- W3011294329 cites W2108435419 @default.
- W3011294329 cites W2110457518 @default.
- W3011294329 cites W2111464898 @default.
- W3011294329 cites W2120987567 @default.
- W3011294329 cites W2121953313 @default.
- W3011294329 cites W2122113931 @default.
- W3011294329 cites W2126795224 @default.
- W3011294329 cites W2129697505 @default.
- W3011294329 cites W2133712961 @default.
- W3011294329 cites W2134886133 @default.
- W3011294329 cites W2135011318 @default.
- W3011294329 cites W2143539224 @default.
- W3011294329 cites W2145954079 @default.
- W3011294329 cites W2147411610 @default.
- W3011294329 cites W2147818403 @default.
- W3011294329 cites W2212511534 @default.
- W3011294329 cites W2324575072 @default.
- W3011294329 cites W2430361330 @default.
- W3011294329 cites W2523492951 @default.
- W3011294329 cites W2535920991 @default.
- W3011294329 cites W2554445601 @default.
- W3011294329 cites W2563994157 @default.
- W3011294329 cites W2590366111 @default.
- W3011294329 cites W2610457025 @default.
- W3011294329 cites W2745470440 @default.
- W3011294329 cites W2746380062 @default.
- W3011294329 cites W2749759400 @default.
- W3011294329 cites W2751417101 @default.
- W3011294329 cites W2754000962 @default.
- W3011294329 cites W2757034452 @default.
- W3011294329 cites W2761368858 @default.
- W3011294329 cites W2767432874 @default.
- W3011294329 cites W2768455179 @default.
- W3011294329 cites W2785178575 @default.
- W3011294329 cites W2794699203 @default.