Matches in SemOpenAlex for { <https://semopenalex.org/work/W3011300740> ?p ?o ?g. }
- W3011300740 endingPage "540" @default.
- W3011300740 startingPage "533" @default.
- W3011300740 abstract "Recent studies revealed that the histone demethylase KDM2B regulates the epithelial markers E-Cadherin and ZO-1, the RhoA/B/C-small-GTPases and actin cytoskeleton organization, in DU-145 prostate- and HCT-116 colon-tumor cells. Here we addressed the role of KDM2B in the activation of Focal Adhesion Kinase (FAK)-signaling and its involvement in regulating tumor cell motility. We used RT-PCR for gene transcriptional analysis, Western blotting for the assessment of protein expression and activity and wound-healing assay for the study of cell migration. KDM2B overexpression or silencing controls the activity of FAK in DU-145 prostate- and HCT-116 colon-tumor cells without affecting gene transcription and protein expression of this kinase. Upon KDM2B overexpression in DU-145 cells, significantly enhanced migration was observed, which was abolished in cells pretreated by the specific phosphoinositide-3 kinase (PI3 K) inhibitor LY294002, implying involvement of FAK/PI3 K signaling in the migration process. In line with this, the p85-PI3 K-subunit was downregulated upon knockdown of KDM2B in DU-145 cells, while the opposite effect became evident in KDM2B-overexpressing cells. These results revealed a novel functional role of KDM2B in regulating the activation of the FAK/PI3 K signaling in prostate cancer cells that participates in the control of cell motility." @default.
- W3011300740 created "2020-03-23" @default.
- W3011300740 creator A5000408030 @default.
- W3011300740 creator A5002321842 @default.
- W3011300740 creator A5032683795 @default.
- W3011300740 creator A5038042103 @default.
- W3011300740 creator A5038851847 @default.
- W3011300740 creator A5043160387 @default.
- W3011300740 creator A5060940239 @default.
- W3011300740 creator A5061727165 @default.
- W3011300740 creator A5074248081 @default.
- W3011300740 creator A5084208566 @default.
- W3011300740 date "2020-03-16" @default.
- W3011300740 modified "2023-09-26" @default.
- W3011300740 title "The histone demethylase KDM2B activates FAK and PI3K that control tumor cell motility" @default.
- W3011300740 cites W1547191505 @default.
- W3011300740 cites W1559296439 @default.
- W3011300740 cites W1920988707 @default.
- W3011300740 cites W1969063564 @default.
- W3011300740 cites W1993457038 @default.
- W3011300740 cites W1997267832 @default.
- W3011300740 cites W1998819602 @default.
- W3011300740 cites W2003831553 @default.
- W3011300740 cites W2012347139 @default.
- W3011300740 cites W2021683914 @default.
- W3011300740 cites W2024432827 @default.
- W3011300740 cites W2026572984 @default.
- W3011300740 cites W2037149683 @default.
- W3011300740 cites W2044406197 @default.
- W3011300740 cites W2045329567 @default.
- W3011300740 cites W2059939225 @default.
- W3011300740 cites W2060712252 @default.
- W3011300740 cites W2071260425 @default.
- W3011300740 cites W2074760925 @default.
- W3011300740 cites W2085591875 @default.
- W3011300740 cites W2086272103 @default.
- W3011300740 cites W2091823241 @default.
- W3011300740 cites W2092138220 @default.
- W3011300740 cites W2094595016 @default.
- W3011300740 cites W2105802577 @default.
- W3011300740 cites W2112545903 @default.
- W3011300740 cites W2121492490 @default.
- W3011300740 cites W2125144796 @default.
- W3011300740 cites W2131827371 @default.
- W3011300740 cites W2152054207 @default.
- W3011300740 cites W2206542436 @default.
- W3011300740 cites W2243111489 @default.
- W3011300740 cites W2281563913 @default.
- W3011300740 cites W2330630740 @default.
- W3011300740 cites W2403989242 @default.
- W3011300740 cites W2479428757 @default.
- W3011300740 cites W2485991133 @default.
- W3011300740 cites W2520842278 @default.
- W3011300740 cites W2568898976 @default.
- W3011300740 cites W2606262935 @default.
- W3011300740 cites W2613093517 @default.
- W3011300740 cites W2613729741 @default.
- W3011300740 cites W2648972079 @default.
- W3011300740 cites W2775062021 @default.
- W3011300740 cites W2783995412 @default.
- W3011300740 cites W2788636481 @default.
- W3011300740 cites W2792349496 @default.
- W3011300740 cites W2803139398 @default.
- W3011300740 cites W2803508839 @default.
- W3011300740 doi "https://doi.org/10.1080/15384047.2020.1736481" @default.
- W3011300740 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7515453" @default.
- W3011300740 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32175798" @default.
- W3011300740 hasPublicationYear "2020" @default.
- W3011300740 type Work @default.
- W3011300740 sameAs 3011300740 @default.
- W3011300740 citedByCount "7" @default.
- W3011300740 countsByYear W30113007402020 @default.
- W3011300740 countsByYear W30113007402021 @default.
- W3011300740 countsByYear W30113007402022 @default.
- W3011300740 crossrefType "journal-article" @default.
- W3011300740 hasAuthorship W3011300740A5000408030 @default.
- W3011300740 hasAuthorship W3011300740A5002321842 @default.
- W3011300740 hasAuthorship W3011300740A5032683795 @default.
- W3011300740 hasAuthorship W3011300740A5038042103 @default.
- W3011300740 hasAuthorship W3011300740A5038851847 @default.
- W3011300740 hasAuthorship W3011300740A5043160387 @default.
- W3011300740 hasAuthorship W3011300740A5060940239 @default.
- W3011300740 hasAuthorship W3011300740A5061727165 @default.
- W3011300740 hasAuthorship W3011300740A5074248081 @default.
- W3011300740 hasAuthorship W3011300740A5084208566 @default.
- W3011300740 hasBestOaLocation W30113007401 @default.
- W3011300740 hasConcept C104317684 @default.
- W3011300740 hasConcept C137738243 @default.
- W3011300740 hasConcept C1491633281 @default.
- W3011300740 hasConcept C151166631 @default.
- W3011300740 hasConcept C185592680 @default.
- W3011300740 hasConcept C2777093181 @default.
- W3011300740 hasConcept C2781364455 @default.
- W3011300740 hasConcept C502942594 @default.
- W3011300740 hasConcept C55493867 @default.
- W3011300740 hasConcept C62478195 @default.
- W3011300740 hasConcept C64927066 @default.
- W3011300740 hasConcept C86803240 @default.